Design of novel artemisinin-like derivatives with cytotoxic and anti-angiogenic properties
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Shahid Soomro
- Tobias Langenberg
- Anne Mahringer
- V Badireenath Konkimalla
- Cindy Horwedel
- Pavlo Holenya
- Almut Brand
- Canan Cetin
- Gert Fricker
- Mieke Dewerchin
- Peter Carmeliet
- Edward M Conway
- Herwig Jansen
- Thomas Efferth
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000291045800012&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1111/j.1582-4934.2010.01120.x
- eISSN
- 1582-4934
- Externe Identifier
- Clarivate Analytics Document Solution ID: 769VG
- PubMed Identifier: 20629994
- ISSN
- 1582-1838
- Ausgabe der Veröffentlichung
- 5
- Zeitschrift
- JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Schlüsselwörter
- malaria
- cancer
- drug resistance
- P-glycoprotein
- chemotherapy
- Paginierung
- 1122 - 1135
- Datum der Veröffentlichung
- 2011
- Status
- Published
- Titel
- Design of novel artemisinin-like derivatives with cytotoxic and anti-angiogenic properties
- Sub types
- Article
- Ausgabe der Zeitschrift
- 15
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Shahid Soomro
- Tobias Langenberg
- Anne Mahringer
- V Badireenath Konkimalla
- Cindy Horwedel
- Pavlo Holenya
- Almut Brand
- Canan Cetin
- Gert Fricker
- Mieke Dewerchin
- Peter Carmeliet
- Edward M Conway
- Herwig Jansen
- Thomas Efferth
- DOI
- 10.1111/j.1582-4934.2010.01120.x
- ISSN
- 1582-1838
- Ausgabe der Veröffentlichung
- 5
- Zeitschrift
- Journal of Cellular and Molecular Medicine
- Sprache
- en
- Online publication date
- 2010
- Paginierung
- 1122 - 1135
- Datum der Veröffentlichung
- 2011
- Status
- Published
- Herausgeber
- Wiley
- Herausgeber URL
- http://dx.doi.org/10.1111/j.1582-4934.2010.01120.x
- Datum der Datenerfassung
- 2021
- Titel
- Design of novel artemisinin-like derivatives with cytotoxic and anti-angiogenic properties
- Ausgabe der Zeitschrift
- 15
Data source: Crossref
- Abstract
- Artemisinins are plant products with a wide range of medicinal applications. Most prominently, artesunate is a well tolerated and effective drug for treating malaria, but is also active against several protozoal and schistosomal infections, and additionally exhibits anti-angiogenic, anti-tumorigenic and anti-viral properties. The array of activities of the artemisinins, and the recent emergence of malaria resistance to artesunate, prompted us to synthesize and evaluate several novel artemisinin-like derivatives. Sixteen distinct derivatives were therefore synthesized and the in vitro cytotoxic effects of each were tested with different cell lines. The in vivo anti-angiogenic properties were evaluated using a zebrafish embryo model. We herein report the identification of several novel artemisinin-like compounds that are easily synthesized, stable at room temperature, may overcome drug-resistance pathways and are more active in vitro and in vivo than the commonly used artesunate. These promising findings raise the hopes of identifying safer and more effective strategies to treat a range of infections and cancer.
- Addresses
- Dafra Pharma Research & Development, Slachthuisstraat, Turnhout, Belgium.
- Autoren
- Shahid Soomro
- Tobias Langenberg
- Anne Mahringer
- V Badireenath Konkimalla
- Cindy Horwedel
- Pavlo Holenya
- Almut Brand
- Canan Cetin
- Gert Fricker
- Mieke Dewerchin
- Peter Carmeliet
- Edward M Conway
- Herwig Jansen
- Thomas Efferth
- Thomas Efferth
- DOI
- 10.1111/j.1582-4934.2010.01120.x
- eISSN
- 1582-4934
- Externe Identifier
- PubMed Identifier: 20629994
- PubMed Central ID: PMC3822625
- Open access
- true
- ISSN
- 1582-1838
- Ausgabe der Veröffentlichung
- 5
- Zeitschrift
- Journal of cellular and molecular medicine
- Schlüsselwörter
- Cells, Cultured
- Animals
- Zebrafish
- Swine
- Artemisia annua
- Artemisinins
- Angiogenesis Inhibitors
- Plant Extracts
- Flow Cytometry
- Cell Proliferation
- Structure-Activity Relationship
- Drug Resistance
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2010
- Open access status
- Open Access
- Paginierung
- 1122 - 1135
- Datum der Veröffentlichung
- 2011
- Status
- Published
- Datum der Datenerfassung
- 2010
- Titel
- Design of novel artemisinin-like derivatives with cytotoxic and anti-angiogenic properties.
- Sub types
- Research Support, Non-U.S. Gov't
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 15
Files
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1582-4934.2010.01120.x https://europepmc.org/articles/PMC3822625?pdf=render
Data source: Europe PubMed Central
- Abstract
- Artemisinins are plant products with a wide range of medicinal applications. Most prominently, artesunate is a well tolerated and effective drug for treating malaria, but is also active against several protozoal and schistosomal infections, and additionally exhibits anti-angiogenic, anti-tumorigenic and anti-viral properties. The array of activities of the artemisinins, and the recent emergence of malaria resistance to artesunate, prompted us to synthesize and evaluate several novel artemisinin-like derivatives. Sixteen distinct derivatives were therefore synthesized and the in vitro cytotoxic effects of each were tested with different cell lines. The in vivo anti-angiogenic properties were evaluated using a zebrafish embryo model. We herein report the identification of several novel artemisinin-like compounds that are easily synthesized, stable at room temperature, may overcome drug-resistance pathways and are more active in vitro and in vivo than the commonly used artesunate. These promising findings raise the hopes of identifying safer and more effective strategies to treat a range of infections and cancer.
- Autoren
- Shahid Soomro
- Tobias Langenberg
- Anne Mahringer
- V Badireenath Konkimalla
- Cindy Horwedel
- Pavlo Holenya
- Almut Brand
- Canan Cetin
- Gert Fricker
- Mieke Dewerchin
- Peter Carmeliet
- Edward M Conway
- Herwig Jansen
- Thomas Efferth
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/20629994
- DOI
- 10.1111/j.1582-4934.2010.01120.x
- eISSN
- 1582-4934
- Externe Identifier
- PubMed Central ID: PMC3822625
- Ausgabe der Veröffentlichung
- 5
- Zeitschrift
- J Cell Mol Med
- Schlüsselwörter
- Angiogenesis Inhibitors
- Animals
- Artemisia annua
- Artemisinins
- Cell Proliferation
- Cells, Cultured
- Drug Resistance
- Flow Cytometry
- Plant Extracts
- Structure-Activity Relationship
- Swine
- Zebrafish
- Sprache
- eng
- Country
- England
- Paginierung
- 1122 - 1135
- PII
- JCMM1120
- Datum der Veröffentlichung
- 2011
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2011
- Titel
- Design of novel artemisinin-like derivatives with cytotoxic and anti-angiogenic properties.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 15
Data source: PubMed
- Beziehungen:
- Property of