Complex Interactions between Phytochemicals. The Multi-Target Therapeutic Concept of Phytotherapy

Publication type:
Journal article
Metadata:
Autoren
  • Thomas Efferth
  • Egon Koch
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000285186300012&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.2174/138945011793591626
eISSN
1873-5592
Externe Identifier
  • Clarivate Analytics Document Solution ID: 692WJ
  • PubMed Identifier: 20735354
ISSN
1389-4501
Ausgabe der Veröffentlichung
1
Zeitschrift
CURRENT DRUG TARGETS
Schlüsselwörter
  • Phytotherapy
  • phytomedicine
  • phytochemicals
  • herbal medicinal products
  • natural products
  • synergy
  • antagonism
Paginierung
122 - 132
Datum der Veröffentlichung
2011
Status
Published
Titel
Complex Interactions between Phytochemicals. The Multi-Target Therapeutic Concept of Phytotherapy
Sub types
  • Review
Ausgabe der Zeitschrift
12

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Thomas Efferth
  • Egon Koch
DOI
10.2174/138945011793591626
ISSN
1389-4501
Ausgabe der Veröffentlichung
1
Zeitschrift
Current Drug Targets
Sprache
en
Paginierung
122 - 132
Datum der Veröffentlichung
2011
Status
Published
Herausgeber
Bentham Science Publishers Ltd.
Herausgeber URL
http://dx.doi.org/10.2174/138945011793591626
Datum der Datenerfassung
2015
Titel
Complex Interactions between Phytochemicals. The Multi-Target Therapeutic Concept of Phytotherapy
Ausgabe der Zeitschrift
12

Data source: Crossref

Abstract
Drugs derived from natural resources represent a significant segment of the pharmaceutical market as compared to randomly synthesized compounds. It is a goal of drug development programs to design selective ligands that act on single disease targets to obtain highly effective and safe drugs with low side effects. Although this strategy was successful for many new therapies, there is a marked decline in the number of new drugs introduced into clinical practice over the past decades. One reason for this failure may be due to the fact that the pathogenesis of many diseases is rather multi-factorial in nature and not due to a single cause. Phytotherapy, whose therapeutic efficacy is based on the combined action of a mixture of constituents, offers new treatment opportunities. Because of their biological defence function, plant secondary metabolites act by targeting and disrupting the cell membrane, by binding and inhibiting specific proteins or they adhere to or intercalate into RNA or DNA. Phytotherapeutics may exhibit pharmacological effects by the synergistic or antagonistic interaction of many phytochemicals. Mechanistic reasons for interactions are bioavailability, interference with cellular transport processes, activation of pro-drugs or deactivation of active compounds to inactive metabolites, action of synergistic partners at different points of the same signalling cascade (multi-target effects) or inhibition of binding to target proteins. "-Omics" technologies and systems biology may facilitate unravelling synergistic effects of herbal mixtures.
Addresses
  • Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Staudinger Weg 5, 55128 Mainz, Germany. efferth@uni-mainz.de
Autoren
DOI
10.2174/138945011793591626
eISSN
1873-5592
Externe Identifier
  • PubMed Identifier: 20735354
Open access
false
ISSN
1389-4501
Ausgabe der Veröffentlichung
1
Zeitschrift
Current drug targets
Schlüsselwörter
  • Animals
  • Humans
  • Plants
  • Oils, Volatile
  • Plant Preparations
  • Plant Extracts
  • Phytotherapy
  • Drug Interactions
  • Drug Synergism
  • Herb-Drug Interactions
Sprache
eng
Medium
Print
Paginierung
122 - 132
Datum der Veröffentlichung
2011
Status
Published
Datum der Datenerfassung
2010
Titel
Complex interactions between phytochemicals. The multi-target therapeutic concept of phytotherapy.
Sub types
  • Review
  • Journal Article
Ausgabe der Zeitschrift
12

Data source: Europe PubMed Central

Abstract
Drugs derived from natural resources represent a significant segment of the pharmaceutical market as compared to randomly synthesized compounds. It is a goal of drug development programs to design selective ligands that act on single disease targets to obtain highly effective and safe drugs with low side effects. Although this strategy was successful for many new therapies, there is a marked decline in the number of new drugs introduced into clinical practice over the past decades. One reason for this failure may be due to the fact that the pathogenesis of many diseases is rather multi-factorial in nature and not due to a single cause. Phytotherapy, whose therapeutic efficacy is based on the combined action of a mixture of constituents, offers new treatment opportunities. Because of their biological defence function, plant secondary metabolites act by targeting and disrupting the cell membrane, by binding and inhibiting specific proteins or they adhere to or intercalate into RNA or DNA. Phytotherapeutics may exhibit pharmacological effects by the synergistic or antagonistic interaction of many phytochemicals. Mechanistic reasons for interactions are bioavailability, interference with cellular transport processes, activation of pro-drugs or deactivation of active compounds to inactive metabolites, action of synergistic partners at different points of the same signalling cascade (multi-target effects) or inhibition of binding to target proteins. "-Omics" technologies and systems biology may facilitate unravelling synergistic effects of herbal mixtures.
Date of acceptance
2010
Autoren
  • Thomas Efferth
  • Egon Koch
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/20735354
DOI
10.2174/138945011793591626
eISSN
1873-5592
Ausgabe der Veröffentlichung
1
Zeitschrift
Curr Drug Targets
Schlüsselwörter
  • Animals
  • Drug Interactions
  • Drug Synergism
  • Herb-Drug Interactions
  • Humans
  • Oils, Volatile
  • Phytotherapy
  • Plant Extracts
  • Plant Preparations
  • Plants
Sprache
eng
Country
United Arab Emirates
Paginierung
122 - 132
PII
BSP/CDT/E-Pub/00154
Datum der Veröffentlichung
2011
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2011
Titel
Complex interactions between phytochemicals. The multi-target therapeutic concept of phytotherapy.
Sub types
  • Journal Article
  • Review
Ausgabe der Zeitschrift
12

Data source: PubMed

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