Fighting mycobacterial infections by antibiotics, phytochemicals and vaccines
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Denise Bamberger
- Nora Jantzer
- Katharina Leidner
- Joachim Arend
- Thomas Efferth
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000292442800001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1016/j.micinf.2010.09.002
- eISSN
- 1769-714X
- Externe Identifier
- Clarivate Analytics Document Solution ID: 788KC
- PubMed Identifier: 20832501
- ISSN
- 1286-4579
- Ausgabe der Veröffentlichung
- 7
- Zeitschrift
- MICROBES AND INFECTION
- Schlüsselwörter
- Buruli ulcer
- Antibiotics
- Natural products
- Phytochemicals
- Vaccination
- Neglected diseases
- Paginierung
- 613 - 623
- Datum der Veröffentlichung
- 2011
- Status
- Published
- Titel
- Fighting mycobacterial infections by antibiotics, phytochemicals and vaccines
- Sub types
- Review
- Ausgabe der Zeitschrift
- 13
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Denise Bamberger
- Nora Jantzer
- Katharina Leidner
- Joachim Arend
- Thomas Efferth
- DOI
- 10.1016/j.micinf.2010.09.002
- ISSN
- 1286-4579
- Ausgabe der Veröffentlichung
- 7
- Zeitschrift
- Microbes and Infection
- Sprache
- en
- Paginierung
- 613 - 623
- Datum der Veröffentlichung
- 2011
- Status
- Published
- Herausgeber
- Elsevier BV
- Herausgeber URL
- http://dx.doi.org/10.1016/j.micinf.2010.09.002
- Datum der Datenerfassung
- 2024
- Titel
- Fighting mycobacterial infections by antibiotics, phytochemicals and vaccines
- Ausgabe der Zeitschrift
- 13
Data source: Crossref
- Abstract
- Buruli ulcer is a neglected disease caused by Mycobacterium ulcerans and represents the world's third most common mycobacterial infection. It produces the polyketide toxins, mycolactones A, B, C and D, which induce apoptosis and necrosis. Clinical symptoms are subcutaneous nodules, papules, plaques and ulcerating oedemae, which can enlarge and destroy nerves and blood vessels and even invade bones by lymphatic or haematogenous spread (osteomyelitis). Patients usually do not suffer from pain or systematic inflammation. Surgery is the treatment of choice, although recurrence is common and wide surgical excisions including healthy tissues result in significant morbidity. Antibiotic therapy with rifamycins, aminoglycosides, macrolides and quinolones also improves cure rates. Still less exploited treatment options are phytochemicals from medicinal plants used in affected countries. Vaccination against Buruli ulcer is still in its infancy.
- Addresses
- Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Staudinger Weg 5, 55128 Mainz, Germany.
- Autoren
- Denise Bamberger
- Nora Jantzer
- Katharina Leidner
- Joachim Arend
- Thomas Efferth
- Thomas Efferth
- DOI
- 10.1016/j.micinf.2010.09.002
- eISSN
- 1769-714X
- Externe Identifier
- PubMed Identifier: 20832501
- Open access
- false
- ISSN
- 1286-4579
- Ausgabe der Veröffentlichung
- 7
- Zeitschrift
- Microbes and infection
- Schlüsselwörter
- Animals
- Humans
- Mycobacterium ulcerans
- Necrosis
- Macrolides
- Quinolones
- Rifamycins
- Aminoglycosides
- Bacterial Proteins
- Chaperonin 60
- Vaccines, DNA
- Bacterial Toxins
- Bacterial Vaccines
- Anti-Bacterial Agents
- Vaccination
- Phytotherapy
- Apoptosis
- Buruli Ulcer
- Neglected Diseases
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2010
- Paginierung
- 613 - 623
- Datum der Veröffentlichung
- 2011
- Status
- Published
- Datum der Datenerfassung
- 2010
- Titel
- Fighting mycobacterial infections by antibiotics, phytochemicals and vaccines.
- Sub types
- Review
- Journal Article
- Ausgabe der Zeitschrift
- 13
Data source: Europe PubMed Central
- Abstract
- Buruli ulcer is a neglected disease caused by Mycobacterium ulcerans and represents the world's third most common mycobacterial infection. It produces the polyketide toxins, mycolactones A, B, C and D, which induce apoptosis and necrosis. Clinical symptoms are subcutaneous nodules, papules, plaques and ulcerating oedemae, which can enlarge and destroy nerves and blood vessels and even invade bones by lymphatic or haematogenous spread (osteomyelitis). Patients usually do not suffer from pain or systematic inflammation. Surgery is the treatment of choice, although recurrence is common and wide surgical excisions including healthy tissues result in significant morbidity. Antibiotic therapy with rifamycins, aminoglycosides, macrolides and quinolones also improves cure rates. Still less exploited treatment options are phytochemicals from medicinal plants used in affected countries. Vaccination against Buruli ulcer is still in its infancy.
- Date of acceptance
- 2010
- Autoren
- Denise Bamberger
- Nora Jantzer
- Katharina Leidner
- Joachim Arend
- Thomas Efferth
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/20832501
- DOI
- 10.1016/j.micinf.2010.09.002
- eISSN
- 1769-714X
- Ausgabe der Veröffentlichung
- 7
- Zeitschrift
- Microbes Infect
- Schlüsselwörter
- Aminoglycosides
- Animals
- Anti-Bacterial Agents
- Apoptosis
- Bacterial Proteins
- Bacterial Toxins
- Bacterial Vaccines
- Buruli Ulcer
- Chaperonin 60
- Humans
- Macrolides
- Mycobacterium ulcerans
- Necrosis
- Neglected Diseases
- Phytotherapy
- Quinolones
- Rifamycins
- Vaccination
- Vaccines, DNA
- Sprache
- eng
- Country
- France
- Paginierung
- 613 - 623
- PII
- S1286-4579(10)00216-9
- Datum der Veröffentlichung
- 2011
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2011
- Titel
- Fighting mycobacterial infections by antibiotics, phytochemicals and vaccines.
- Sub types
- Journal Article
- Review
- Ausgabe der Zeitschrift
- 13
Data source: PubMed
- Beziehungen:
- Property of