EVALUATION OF DRUG TRANSPORTERS' SIGNIFICANCE FOR MULTIDRUG RESISTANCE IN HEAD AND NECK SQUAMOUS CELL CARCINOMA

Publication type:
Journal article
Metadata:
Autoren
  • Dirk Theile
  • Nahal Ketabi-Kiyanvash
  • Christel Herold-Mende
  • Gerhardt Dyckhoff
  • Thomas Efferth
  • Vincent Bertholet
  • Walter Emil Haefeli
  • Johanna Weiss
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000292549100007&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1002/hed.21559
eISSN
1097-0347
Externe Identifier
  • Clarivate Analytics Document Solution ID: 789WL
  • PubMed Identifier: 20737486
ISSN
1043-3074
Ausgabe der Veröffentlichung
7
Zeitschrift
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
Schlüsselwörter
  • head and neck squamous cell carcinoma (HNSCC)
  • drug transporters
  • multidrug resistance
  • cross-resistance
Paginierung
959 - 968
Datum der Veröffentlichung
2011
Status
Published
Titel
EVALUATION OF DRUG TRANSPORTERS' SIGNIFICANCE FOR MULTIDRUG RESISTANCE IN HEAD AND NECK SQUAMOUS CELL CARCINOMA
Sub types
  • Article
Ausgabe der Zeitschrift
33

Data source: Web of Science (Lite)

Other metadata sources:
Abstract
<jats:title>Abstract</jats:title><jats:sec><jats:title>Background.</jats:title><jats:p>Multidrug resistance (MDR) hampers chemotherapy in head and neck squamous cell carcinoma (HNSCC). There is little information about MDR mediating drug transporters in HNSCC.</jats:p></jats:sec><jats:sec><jats:title>Methods.</jats:title><jats:p>Nine HNSCC cell lines were characterized concerning drug transporter expression and susceptibility to cisplatin, paclitaxel, and 5‐fluorouracil (5‐FU) using a DNA microarray and proliferation assays. Three cells lines were precisely investigated for transporter expression using reverse transcriptase‐polymerase chain reaction (RT‐PCR) and drug resistance before and after simulated chemotherapies.</jats:p></jats:sec><jats:sec><jats:title>Results.</jats:title><jats:p>The cell lines differed in drug resistance and transporter expression. Cisplatin and paclitaxel resistances were inversely associated. Drugs rendered HNSCC cells resistant, cross‐resistant, or cross‐sensitive. Sensitivity changes were accompanied by transporter mRNA expression changes.</jats:p></jats:sec><jats:sec><jats:title>Conclusion.</jats:title><jats:p>Paclitaxel was identified as a potent inducer of numerous drug transporters and phenotypic MDR in HNSCC. Thus, cytostatic susceptibility of HNSCC cannot exclusively be deduced from the expression of single transporters but more likely of the entire transportome and non‐transporter modulators. © 2010 Wiley Periodicals, Inc. Head Neck, 2011</jats:p></jats:sec>
Autoren
  • Dirk Theile
  • Nahal Ketabi‐Kiyanvash
  • Christel Herold‐Mende
  • Gerhardt Dyckhoff
  • Thomas Efferth
  • Vincent Bertholet
  • Walter Emil Haefeli
  • Johanna Weiss
DOI
10.1002/hed.21559
eISSN
1097-0347
ISSN
1043-3074
Ausgabe der Veröffentlichung
7
Zeitschrift
Head &amp; Neck
Sprache
en
Online publication date
2010
Paginierung
959 - 968
Datum der Veröffentlichung
2011
Status
Published
Herausgeber
Wiley
Herausgeber URL
http://dx.doi.org/10.1002/hed.21559
Datum der Datenerfassung
2023
Titel
Evaluation of drug transporters' significance for multidrug resistance in head and neck squamous cell carcinoma
Ausgabe der Zeitschrift
33

Data source: Crossref

Abstract
<h4>Background</h4>Multidrug resistance (MDR) hampers chemotherapy in head and neck squamous cell carcinoma (HNSCC). There is little information about MDR mediating drug transporters in HNSCC.<h4>Methods</h4>Nine HNSCC cell lines were characterized concerning drug transporter expression and susceptibility to cisplatin, paclitaxel, and 5-fluorouracil (5-FU) using a DNA microarray and proliferation assays. Three cells lines were precisely investigated for transporter expression using reverse transcriptase-polymerase chain reaction (RT-PCR) and drug resistance before and after simulated chemotherapies.<h4>Results</h4>The cell lines differed in drug resistance and transporter expression. Cisplatin and paclitaxel resistances were inversely associated. Drugs rendered HNSCC cells resistant, cross-resistant, or cross-sensitive. Sensitivity changes were accompanied by transporter mRNA expression changes.<h4>Conclusion</h4>Paclitaxel was identified as a potent inducer of numerous drug transporters and phenotypic MDR in HNSCC. Thus, cytostatic susceptibility of HNSCC cannot exclusively be deduced from the expression of single transporters but more likely of the entire transportome and non-transporter modulators.
Addresses
  • Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
Autoren
  • Dirk Theile
  • Nahal Ketabi-Kiyanvash
  • Christel Herold-Mende
  • Gerhardt Dyckhoff
  • Thomas Efferth
  • Thomas Efferth
  • Vincent Bertholet
  • Walter Emil Haefeli
  • Johanna Weiss
DOI
10.1002/hed.21559
eISSN
1097-0347
Externe Identifier
  • PubMed Identifier: 20737486
Open access
false
ISSN
1043-3074
Ausgabe der Veröffentlichung
7
Zeitschrift
Head & neck
Schlüsselwörter
  • Cell Line, Tumor
  • Humans
  • Carcinoma, Squamous Cell
  • Head and Neck Neoplasms
  • Cisplatin
  • Paclitaxel
  • Fluorouracil
  • Membrane Transport Proteins
  • Multidrug Resistance-Associated Proteins
  • Antimetabolites, Antineoplastic
  • Antineoplastic Agents, Phytogenic
  • Oligonucleotide Array Sequence Analysis
  • Drug Resistance, Multiple
  • Cell Proliferation
  • Drug Resistance, Neoplasm
  • Adult
  • Aged
  • Middle Aged
  • Cytostatic Agents
  • Squamous Cell Carcinoma of Head and Neck
Sprache
eng
Medium
Print-Electronic
Online publication date
2010
Paginierung
959 - 968
Datum der Veröffentlichung
2011
Status
Published
Datum der Datenerfassung
2010
Titel
Evaluation of drug transporters' significance for multidrug resistance in head and neck squamous cell carcinoma.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
33

Data source: Europe PubMed Central

Abstract
BACKGROUND: Multidrug resistance (MDR) hampers chemotherapy in head and neck squamous cell carcinoma (HNSCC). There is little information about MDR mediating drug transporters in HNSCC. METHODS: Nine HNSCC cell lines were characterized concerning drug transporter expression and susceptibility to cisplatin, paclitaxel, and 5-fluorouracil (5-FU) using a DNA microarray and proliferation assays. Three cells lines were precisely investigated for transporter expression using reverse transcriptase-polymerase chain reaction (RT-PCR) and drug resistance before and after simulated chemotherapies. RESULTS: The cell lines differed in drug resistance and transporter expression. Cisplatin and paclitaxel resistances were inversely associated. Drugs rendered HNSCC cells resistant, cross-resistant, or cross-sensitive. Sensitivity changes were accompanied by transporter mRNA expression changes. CONCLUSION: Paclitaxel was identified as a potent inducer of numerous drug transporters and phenotypic MDR in HNSCC. Thus, cytostatic susceptibility of HNSCC cannot exclusively be deduced from the expression of single transporters but more likely of the entire transportome and non-transporter modulators.
Date of acceptance
2010
Autoren
  • Dirk Theile
  • Nahal Ketabi-Kiyanvash
  • Christel Herold-Mende
  • Gerhardt Dyckhoff
  • Thomas Efferth
  • Vincent Bertholet
  • Walter Emil Haefeli
  • Johanna Weiss
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/20737486
DOI
10.1002/hed.21559
eISSN
1097-0347
Ausgabe der Veröffentlichung
7
Zeitschrift
Head Neck
Schlüsselwörter
  • Adult
  • Aged
  • Antimetabolites, Antineoplastic
  • Antineoplastic Agents, Phytogenic
  • Carcinoma, Squamous Cell
  • Cell Line, Tumor
  • Cell Proliferation
  • Cisplatin
  • Cytostatic Agents
  • Drug Resistance, Multiple
  • Drug Resistance, Neoplasm
  • Fluorouracil
  • Head and Neck Neoplasms
  • Humans
  • Membrane Transport Proteins
  • Middle Aged
  • Multidrug Resistance-Associated Proteins
  • Oligonucleotide Array Sequence Analysis
  • Paclitaxel
  • Squamous Cell Carcinoma of Head and Neck
Sprache
eng
Country
United States
Paginierung
959 - 968
Datum der Veröffentlichung
2011
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2011
Titel
Evaluation of drug transporters' significance for multidrug resistance in head and neck squamous cell carcinoma.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
33

Data source: PubMed

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