Natural Products Derived from Traditional Chinese Medicine as Novel Inhibitors of the Epidermal Growth Factor Receptor

Publication type:
Journal article
Metadata:
Autoren
  • Serkan Sertel
  • Peter K Plinkert
  • Thomas Efferth
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000284622300004&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.2174/138620710793360266
Externe Identifier
  • Clarivate Analytics Document Solution ID: 685IL
  • PubMed Identifier: 20883187
ISSN
1386-2073
Ausgabe der Veröffentlichung
10
Zeitschrift
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
Schlüsselwörter
  • Cancer
  • drug resistance
  • epidermal growth factor receptor (EGFR)
  • EGFR tyrosine kinase inhibitor
  • medicinal plant
  • natural product
Paginierung
849 - 854
Datum der Veröffentlichung
2010
Status
Published
Titel
Natural Products Derived from Traditional Chinese Medicine as Novel Inhibitors of the Epidermal Growth Factor Receptor
Sub types
  • Article
Ausgabe der Zeitschrift
13

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Serkan Sertel
  • Peter K. Plinkert
  • Thomas Efferth
DOI
10.2174/138620710793360266
ISSN
1386-2073
Ausgabe der Veröffentlichung
10
Zeitschrift
Combinatorial Chemistry & High Throughput Screening
Sprache
en
Paginierung
849 - 854
Datum der Veröffentlichung
2010
Status
Published
Herausgeber
Bentham Science Publishers Ltd.
Herausgeber URL
http://dx.doi.org/10.2174/138620710793360266
Datum der Datenerfassung
2015
Titel
Natural Products Derived from Traditional Chinese Medicine as Novel Inhibitors of the Epidermal Growth Factor Receptor
Ausgabe der Zeitschrift
13

Data source: Crossref

Abstract
The epidermal growth factor receptor (EGFR) has become an important molecular target in cancer therapy. Various small molecules and therapeutic antibodies targeting EGFR family members have been developed during recent years and are established in clinical oncology. However, increasing clinical application of EGFR tyrosine kinase inhibitors has resulted in the development of resistance to EGFR-targeting drugs due to the selection of EGFR-mutated variants. This phenomenon forced the search for novel EGFR inhibitors with activity towards EGFR-mutant tumors. This review describes recent achievements in natural products derived from medicinal plants as novel EGFR inhibitors.
Addresses
  • Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Staudingerweg 5, 55128 Mainz, Germany.
Autoren
DOI
10.2174/138620710793360266
eISSN
1875-5402
Externe Identifier
  • PubMed Identifier: 20883187
Open access
false
ISSN
1386-2073
Ausgabe der Veröffentlichung
10
Zeitschrift
Combinatorial chemistry & high throughput screening
Schlüsselwörter
  • Animals
  • Humans
  • Plants, Medicinal
  • Neoplasms
  • Drugs, Chinese Herbal
  • Antineoplastic Agents, Phytogenic
  • Medicine, Chinese Traditional
  • ErbB Receptors
Sprache
eng
Medium
Print
Paginierung
849 - 854
Datum der Veröffentlichung
2010
Status
Published
Datum der Datenerfassung
2010
Titel
Natural products derived from traditional chinese medicine as novel inhibitors of the epidermal growth factor receptor.
Sub types
  • Review
  • Journal Article
Ausgabe der Zeitschrift
13

Data source: Europe PubMed Central

Abstract
The epidermal growth factor receptor (EGFR) has become an important molecular target in cancer therapy. Various small molecules and therapeutic antibodies targeting EGFR family members have been developed during recent years and are established in clinical oncology. However, increasing clinical application of EGFR tyrosine kinase inhibitors has resulted in the development of resistance to EGFR-targeting drugs due to the selection of EGFR-mutated variants. This phenomenon forced the search for novel EGFR inhibitors with activity towards EGFR-mutant tumors. This review describes recent achievements in natural products derived from medicinal plants as novel EGFR inhibitors.
Date of acceptance
2010
Autoren
  • Serkan Sertel
  • Peter K Plinkert
  • Thomas Efferth
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/20883187
DOI
10.2174/138620710793360266
eISSN
1875-5402
Ausgabe der Veröffentlichung
10
Zeitschrift
Comb Chem High Throughput Screen
Schlüsselwörter
  • Animals
  • Antineoplastic Agents, Phytogenic
  • Drugs, Chinese Herbal
  • ErbB Receptors
  • Humans
  • Medicine, Chinese Traditional
  • Neoplasms
  • Plants, Medicinal
Sprache
eng
Country
United Arab Emirates
Paginierung
849 - 854
PII
BSP/CCHTS/E-Pub/00116
Datum der Veröffentlichung
2010
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2011
Titel
Natural products derived from traditional chinese medicine as novel inhibitors of the epidermal growth factor receptor.
Sub types
  • Journal Article
  • Review
Ausgabe der Zeitschrift
13

Data source: PubMed

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