Transcript profiling identifies novel key players mediating the growth inhibitory effect of NS-398 on human pancreatic cancer cells

Publication type:
Journal article
Metadata:
Autoren
  • Mahmoud Youns
  • Thomas Efferth
  • Jorg D Hoheisel
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000285893800023&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.ejphar.2010.10.026
eISSN
1879-0712
Externe Identifier
  • Clarivate Analytics Document Solution ID: 702KR
  • PubMed Identifier: 20969859
ISSN
0014-2999
Ausgabe der Veröffentlichung
1
Zeitschrift
EUROPEAN JOURNAL OF PHARMACOLOGY
Schlüsselwörter
  • Pancreatic cancer
  • Microarray
  • Ingenuity
  • NS-398
Paginierung
170 - 177
Datum der Veröffentlichung
2011
Status
Published
Titel
Transcript profiling identifies novel key players mediating the growth inhibitory effect of NS-398 on human pancreatic cancer cells
Sub types
  • Article
Ausgabe der Zeitschrift
650

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Mahmoud Youns
  • Thomas Efferth
  • Jörg D Hoheisel
DOI
10.1016/j.ejphar.2010.10.026
ISSN
0014-2999
Ausgabe der Veröffentlichung
1
Zeitschrift
European Journal of Pharmacology
Sprache
en
Paginierung
170 - 177
Datum der Veröffentlichung
2011
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.ejphar.2010.10.026
Datum der Datenerfassung
2021
Titel
Transcript profiling identifies novel key players mediating the growth inhibitory effect of NS-398 on human pancreatic cancer cells
Ausgabe der Zeitschrift
650

Data source: Crossref

Abstract
Pancreatic cancer is one of the most aggressive human malignancies with an increasing incidence worldwide. Despite an increase in the number of systemic treatments available for pancreatic cancer, the impact of therapy on the clinical course of the disease has been modest, underscoring an urgent need for new therapeutic options. Although selective cyclooxygenase-2 inhibitors have been demonstrated to have cancer-preventive effects, the mechanism of their effects is not clearly known. Moreover, there have been no unbiased studies to identify novel molecular targets of NS-398 regarding pancreatic cancer. Here we undertook a gene expression profiling study to identify novel molecular targets modulating the growth inhibitory effects of NS-398 on pancreatic cancer cell lines. Our mRNA-based gene expression results showed that the growth inhibitory effect of NS-398 was accompanied with an activation of G1/S and G2/M cell cycle regulation, P53 signalling, apoptotic, aryl hydrocarbon receptor and death receptor signalling pathways. Moreover, we reported, for the first time, that the growth inhibitory effect of NS-398 is mediated by down-regulation of RRM2, CTGF, MCM2 and PCNA and up-regulation of NAG-1 in all cell lines.
Addresses
  • Functional Genome Analysis, German Cancer Research Centre (DKFZ), Im Neuenheimer Feld 580, 69120 Heidelberg, Germany. m.youns@dkfz.de
Autoren
DOI
10.1016/j.ejphar.2010.10.026
eISSN
1879-0712
Externe Identifier
  • PubMed Identifier: 20969859
Open access
false
ISSN
0014-2999
Ausgabe der Veröffentlichung
1
Zeitschrift
European journal of pharmacology
Schlüsselwörter
  • Cell Line, Tumor
  • Humans
  • Pancreatic Neoplasms
  • Sulfonamides
  • Nitrobenzenes
  • Oligonucleotide Array Sequence Analysis
  • Gene Expression Profiling
  • Apoptosis
  • Cell Proliferation
  • Down-Regulation
  • Up-Regulation
Sprache
eng
Medium
Print-Electronic
Online publication date
2010
Paginierung
170 - 177
Datum der Veröffentlichung
2011
Status
Published
Datum der Datenerfassung
2010
Titel
Transcript profiling identifies novel key players mediating the growth inhibitory effect of NS-398 on human pancreatic cancer cells.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
650

Data source: Europe PubMed Central

Abstract
Pancreatic cancer is one of the most aggressive human malignancies with an increasing incidence worldwide. Despite an increase in the number of systemic treatments available for pancreatic cancer, the impact of therapy on the clinical course of the disease has been modest, underscoring an urgent need for new therapeutic options. Although selective cyclooxygenase-2 inhibitors have been demonstrated to have cancer-preventive effects, the mechanism of their effects is not clearly known. Moreover, there have been no unbiased studies to identify novel molecular targets of NS-398 regarding pancreatic cancer. Here we undertook a gene expression profiling study to identify novel molecular targets modulating the growth inhibitory effects of NS-398 on pancreatic cancer cell lines. Our mRNA-based gene expression results showed that the growth inhibitory effect of NS-398 was accompanied with an activation of G1/S and G2/M cell cycle regulation, P53 signalling, apoptotic, aryl hydrocarbon receptor and death receptor signalling pathways. Moreover, we reported, for the first time, that the growth inhibitory effect of NS-398 is mediated by down-regulation of RRM2, CTGF, MCM2 and PCNA and up-regulation of NAG-1 in all cell lines.
Date of acceptance
2010
Autoren
  • Mahmoud Youns
  • Thomas Efferth
  • Jörg D Hoheisel
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/20969859
DOI
10.1016/j.ejphar.2010.10.026
eISSN
1879-0712
Ausgabe der Veröffentlichung
1
Zeitschrift
Eur J Pharmacol
Schlüsselwörter
  • Apoptosis
  • Cell Line, Tumor
  • Cell Proliferation
  • Down-Regulation
  • Gene Expression Profiling
  • Humans
  • Nitrobenzenes
  • Oligonucleotide Array Sequence Analysis
  • Pancreatic Neoplasms
  • Sulfonamides
  • Up-Regulation
Sprache
eng
Country
Netherlands
Paginierung
170 - 177
PII
S0014-2999(10)01048-4
Datum der Veröffentlichung
2011
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2011
Titel
Transcript profiling identifies novel key players mediating the growth inhibitory effect of NS-398 on human pancreatic cancer cells.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
650

Data source: PubMed

Beziehungen:
Property of

Tools