Toxicogenomics for the Prediction of Toxicity Related to Herbs from Traditional Chinese Medicine

Publication type:
Journal article
Metadata:
Autoren
  • Mahmoud Youns
  • Joerg D Hoheisel
  • Thomas Efferth
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000284941000010&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1055/s-0030-1250432
Externe Identifier
  • Clarivate Analytics Document Solution ID: 689PR
  • PubMed Identifier: 20957595
ISSN
0032-0943
Ausgabe der Veröffentlichung
17
Zeitschrift
PLANTA MEDICA
Schlüsselwörter
  • toxicogenomics
  • traditional Chinese medicine
  • microarray
  • medicinal herbs
Paginierung
2019 - 2025
Datum der Veröffentlichung
2010
Status
Published
Titel
Toxicogenomics for the Prediction of Toxicity Related to Herbs from Traditional Chinese Medicine
Sub types
  • Review
Ausgabe der Zeitschrift
76

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Mahmoud Youns
  • Jörg Hoheisel
  • Thomas Efferth
DOI
10.1055/s-0030-1250432
eISSN
1439-0221
ISSN
0032-0943
Ausgabe der Veröffentlichung
17
Zeitschrift
Planta Medica
Sprache
en
Online publication date
2010
Paginierung
2019 - 2025
Datum der Veröffentlichung
2010
Status
Published
Herausgeber
Georg Thieme Verlag KG
Herausgeber URL
http://dx.doi.org/10.1055/s-0030-1250432
Datum der Datenerfassung
2017
Titel
Toxicogenomics for the Prediction of Toxicity Related to Herbs from Traditional Chinese Medicine
Ausgabe der Zeitschrift
76

Data source: Crossref

Abstract
Toxicogenomics represents the integration of genomics and toxicology to investigate the interaction between genes and environmental stress in human health. It is a scientific field that studies how the genome is involved in responses to environmental stressors and toxicants. The patterns of altered gene expression that are caused by specific exposures or disease outcomes reveal how toxicants may act and cause disease. Nowadays, toxicogenomics faces great challenges in discriminating the molecular basis of toxicity. We do believe that advances in this field will eventually allow us to describe all the toxicological interactions that occur within a living system. Toxicogenomic responses of a toxic agent in one species (e.g., laboratory animals) may predict the mode of action in another species (e.g., humans) (predictive toxicology). Development and application of toxicogenomic databases and new bioinformatics tools are among the most important aspects of toxicogenomic research which will facilitate sharing and interpretation of the huge amount of biological information generated in this field. Medicinal herbs have played an important role in pharmacy from ancient to modern times. Nowadays, there is a revival of interest in medicinal plants and an increasing scientific interest in bioactive natural products. Medicinal herbs are usually considered to be nontoxic. However, the consumption of herbs could produce prominent toxic effects either due to inherent toxicity or to contaminants (heavy metals, microorganisms, pesticides, toxic organic solvents, radioactivity, etc.). Therefore, a critical assessment of their toxicity is an urgent issue. This review explores the field of toxicogenomics, pinpoints some of its research approaches and describes the challenges it faces. In particular, Chinese herbal preparations have been implicated.
Addresses
  • Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Staudinger Weg 5, Mainz, Germany.
Autoren
DOI
10.1055/s-0030-1250432
eISSN
1439-0221
Externe Identifier
  • PubMed Identifier: 20957595
Open access
false
ISSN
0032-0943
Ausgabe der Veröffentlichung
17
Zeitschrift
Planta medica
Schlüsselwörter
  • Animals
  • Humans
  • Plants, Medicinal
  • Drugs, Chinese Herbal
  • Medicine, Chinese Traditional
  • Gene Expression Profiling
  • Proteomics
  • Computational Biology
  • Genomics
  • Toxicogenetics
  • Toxicology
  • Quality Control
  • Databases, Factual
  • Metabolomics
Sprache
eng
Medium
Print-Electronic
Online publication date
2010
Paginierung
2019 - 2025
Datum der Veröffentlichung
2010
Status
Published
Datum der Datenerfassung
2010
Titel
Toxicogenomics for the prediction of toxicity related to herbs from traditional Chinese medicine.
Sub types
  • Review
  • Journal Article
Ausgabe der Zeitschrift
76

Data source: Europe PubMed Central

Abstract
Toxicogenomics represents the integration of genomics and toxicology to investigate the interaction between genes and environmental stress in human health. It is a scientific field that studies how the genome is involved in responses to environmental stressors and toxicants. The patterns of altered gene expression that are caused by specific exposures or disease outcomes reveal how toxicants may act and cause disease. Nowadays, toxicogenomics faces great challenges in discriminating the molecular basis of toxicity. We do believe that advances in this field will eventually allow us to describe all the toxicological interactions that occur within a living system. Toxicogenomic responses of a toxic agent in one species (e.g., laboratory animals) may predict the mode of action in another species (e.g., humans) (predictive toxicology). Development and application of toxicogenomic databases and new bioinformatics tools are among the most important aspects of toxicogenomic research which will facilitate sharing and interpretation of the huge amount of biological information generated in this field. Medicinal herbs have played an important role in pharmacy from ancient to modern times. Nowadays, there is a revival of interest in medicinal plants and an increasing scientific interest in bioactive natural products. Medicinal herbs are usually considered to be nontoxic. However, the consumption of herbs could produce prominent toxic effects either due to inherent toxicity or to contaminants (heavy metals, microorganisms, pesticides, toxic organic solvents, radioactivity, etc.). Therefore, a critical assessment of their toxicity is an urgent issue. This review explores the field of toxicogenomics, pinpoints some of its research approaches and describes the challenges it faces. In particular, Chinese herbal preparations have been implicated.
Autoren
  • Mahmoud Youns
  • Jörg D Hoheisel
  • Thomas Efferth
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/20957595
DOI
10.1055/s-0030-1250432
eISSN
1439-0221
Ausgabe der Veröffentlichung
17
Zeitschrift
Planta Med
Schlüsselwörter
  • Animals
  • Computational Biology
  • Databases, Factual
  • Drugs, Chinese Herbal
  • Gene Expression Profiling
  • Genomics
  • Humans
  • Medicine, Chinese Traditional
  • Metabolomics
  • Plants, Medicinal
  • Proteomics
  • Quality Control
  • Toxicogenetics
  • Toxicology
Sprache
eng
Country
Germany
Paginierung
2019 - 2025
Datum der Veröffentlichung
2010
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2011
Titel
Toxicogenomics for the prediction of toxicity related to herbs from traditional Chinese medicine.
Sub types
  • Journal Article
  • Review
Ausgabe der Zeitschrift
76

Data source: PubMed

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