Antioxidant Activities and Xanthine Oxidase Inhibitory Effects of Extracts and Main Polyphenolic Compounds Obtained from Geranium sibiricum L.

Publication type:
Journal article
Metadata:
Autoren
  • Nan Wu
  • Yuangang Zu
  • Yujie Fu
  • Yu Kong
  • Jintong Zhao
  • Xiajuan Li
  • Ji Li
  • Michael Wink
  • Thomas Efferth
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000276782100029&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1021/jf904593n
eISSN
1520-5118
Externe Identifier
  • Clarivate Analytics Document Solution ID: 584VR
  • PubMed Identifier: 21128613
ISSN
0021-8561
Ausgabe der Veröffentlichung
8
Zeitschrift
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Schlüsselwörter
  • Geranium sibiricum L.
  • polyphenolic compounds
  • antioxidant activity
  • xanthine oxidase
Paginierung
4737 - 4743
Datum der Veröffentlichung
2010
Status
Published
Titel
Antioxidant Activities and Xanthine Oxidase Inhibitory Effects of Extracts and Main Polyphenolic Compounds Obtained from <i>Geranium sibiricum</i> L.
Sub types
  • Article
Ausgabe der Zeitschrift
58

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Nan Wu
  • Yu Kong
  • Yujie Fu
  • Yuangang Zu
  • Zhiwei Yang
  • Mei Yang
  • Xiao Peng
  • Thomas Efferth
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000285735200054&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1021/jf103970b
eISSN
1520-5118
Externe Identifier
  • Clarivate Analytics Document Solution ID: 700JP
  • PubMed Identifier: 21128613
ISSN
0021-8561
Ausgabe der Veröffentlichung
1
Zeitschrift
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Schlüsselwörter
  • Cajaninstilbene acid
  • stilbene
  • antioxidant activity
  • xanthine oxidase
  • DNA damage
Paginierung
437 - 443
Datum der Veröffentlichung
2011
Status
Published
Titel
<i>In Vitro</i> Antioxidant Properties, DNA Damage Protective Activity, and Xanthine Oxidase Inhibitory Effect of Cajaninstilbene Acid, a Stilbene Compound Derived from Pigeon Pea [<i>Cajanus cajan</i> (L.) Millsp.] Leaves
Sub types
  • Article
Ausgabe der Zeitschrift
59

Data source: Web of Science (Lite)

Autoren
  • Nan Wu
  • Yu Kong
  • Yujie Fu
  • Yuangang Zu
  • Zhiwei Yang
  • Mei Yang
  • Xiao Peng
  • Thomas Efferth
DOI
10.1021/jf103970b
eISSN
1520-5118
ISSN
0021-8561
Ausgabe der Veröffentlichung
1
Zeitschrift
Journal of Agricultural and Food Chemistry
Sprache
en
Online publication date
2010
Paginierung
437 - 443
Datum der Veröffentlichung
2011
Status
Published
Herausgeber
American Chemical Society (ACS)
Herausgeber URL
http://dx.doi.org/10.1021/jf103970b
Datum der Datenerfassung
2023
Titel
<i>In Vitro</i> Antioxidant Properties, DNA Damage Protective Activity, and Xanthine Oxidase Inhibitory Effect of Cajaninstilbene Acid, a Stilbene Compound Derived from Pigeon Pea [<i>Cajanus cajan</i> (L.) Millsp.] Leaves
Ausgabe der Zeitschrift
59

Data source: Crossref

Abstract
The antioxidant properties, DNA damage protective activities, and xanthine oxidase (XOD) inhibitory effect of cajaninstilbene acid (CSA) derived from pigeon pea leaves were studied in the present work. Compared with resveratrol, CSA showed stronger antioxidant properties, DNA damage protective activity, and XOD inhibition activity. The IC(50) values of CSA for superoxide radical scavenging, hydroxyl radical scavenging, nitric oxide scavenging, reducing power, lipid peroxidation, and XOD inhibition were 19.03, 6.36, 39.65, 20.41, 20.58, and 3.62 μM, respectively. CSA possessed good protective activity from oxidative DNA damage. Furthermore, molecular docking indicated that CSA was more potent than resveratrol or allopurinol to interact with the active site of XOD (calculated free binding energy: -229.71 kcal mol(-1)). On the basis of the results, we conclude that CSA represents a valuable natural antioxidant source and may potentially be applicable in health food industry.
Addresses
  • Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin, China.
Autoren
  • Nan Wu
  • Yu Kong
  • Yujie Fu
  • Yuangang Zu
  • Zhiwei Yang
  • Mei Yang
  • Xiao Peng
  • Thomas Efferth
DOI
10.1021/jf103970b
eISSN
1520-5118
Externe Identifier
  • PubMed Identifier: 21128613
Open access
false
ISSN
0021-8561
Ausgabe der Veröffentlichung
1
Zeitschrift
Journal of agricultural and food chemistry
Schlüsselwörter
  • Humans
  • Cajanus
  • Plant Leaves
  • DNA Damage
  • Salicylates
  • Stilbenes
  • Xanthine Oxidase
  • DNA, Bacterial
  • Plant Extracts
  • Enzyme Inhibitors
  • Antimutagenic Agents
  • Antioxidants
Sprache
eng
Medium
Print-Electronic
Online publication date
2010
Paginierung
437 - 443
Datum der Veröffentlichung
2011
Status
Published
Datum der Datenerfassung
2010
Titel
In vitro antioxidant properties, DNA damage protective activity, and xanthine oxidase inhibitory effect of cajaninstilbene acid, a stilbene compound derived from pigeon pea [Cajanus cajan (L.) Millsp.] leaves.
Sub types
  • Research Support, Non-U.S. Gov't
  • Journal Article
Ausgabe der Zeitschrift
59

Data source: Europe PubMed Central

Abstract
The antioxidant properties, DNA damage protective activities, and xanthine oxidase (XOD) inhibitory effect of cajaninstilbene acid (CSA) derived from pigeon pea leaves were studied in the present work. Compared with resveratrol, CSA showed stronger antioxidant properties, DNA damage protective activity, and XOD inhibition activity. The IC(50) values of CSA for superoxide radical scavenging, hydroxyl radical scavenging, nitric oxide scavenging, reducing power, lipid peroxidation, and XOD inhibition were 19.03, 6.36, 39.65, 20.41, 20.58, and 3.62 μM, respectively. CSA possessed good protective activity from oxidative DNA damage. Furthermore, molecular docking indicated that CSA was more potent than resveratrol or allopurinol to interact with the active site of XOD (calculated free binding energy: -229.71 kcal mol(-1)). On the basis of the results, we conclude that CSA represents a valuable natural antioxidant source and may potentially be applicable in health food industry.
Autoren
  • Nan Wu
  • Yu Kong
  • Yujie Fu
  • Yuangang Zu
  • Zhiwei Yang
  • Mei Yang
  • Xiao Peng
  • Thomas Efferth
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/21128613
DOI
10.1021/jf103970b
eISSN
1520-5118
Ausgabe der Veröffentlichung
1
Zeitschrift
J Agric Food Chem
Schlüsselwörter
  • Antimutagenic Agents
  • Antioxidants
  • Cajanus
  • DNA Damage
  • DNA, Bacterial
  • Enzyme Inhibitors
  • Humans
  • Plant Extracts
  • Plant Leaves
  • Salicylates
  • Stilbenes
  • Xanthine Oxidase
Sprache
eng
Country
United States
Paginierung
437 - 443
Datum der Veröffentlichung
2011
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2011
Titel
In vitro antioxidant properties, DNA damage protective activity, and xanthine oxidase inhibitory effect of cajaninstilbene acid, a stilbene compound derived from pigeon pea [Cajanus cajan (L.) Millsp.] leaves.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
59

Data source: PubMed

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