Chemistry and Pharmacology of Neglected Helminthic Diseases

Publication type:
Journal article
Metadata:
Autoren
  • A Muellner
  • A Helfer
  • D Kotlyar
  • J Oswald
  • T Efferth
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000287301600006&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.2174/092986711794480096
eISSN
1875-533X
Externe Identifier
  • Clarivate Analytics Document Solution ID: 720SS
  • PubMed Identifier: 21182483
ISSN
0929-8673
Ausgabe der Veröffentlichung
5
Zeitschrift
CURRENT MEDICINAL CHEMISTRY
Schlüsselwörter
  • Neglected diseases
  • lymphatic filariasis
  • drancunculiasis
  • schistosomiasis
  • onchocerciasis
  • helminths
  • anthelminthic drugs
Paginierung
767 - 789
Datum der Veröffentlichung
2011
Status
Published
Titel
Chemistry and Pharmacology of Neglected Helminthic Diseases
Sub types
  • Review
Ausgabe der Zeitschrift
18

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • A Mullner
  • A Helfer
  • D Kotlyar
  • J Oswald
  • T Efferth
DOI
10.2174/092986711794480096
ISSN
0929-8673
Ausgabe der Veröffentlichung
5
Zeitschrift
Current Medicinal Chemistry
Sprache
en
Paginierung
767 - 789
Datum der Veröffentlichung
2011
Status
Published
Herausgeber
Bentham Science Publishers Ltd.
Herausgeber URL
http://dx.doi.org/10.2174/092986711794480096
Datum der Datenerfassung
2015
Titel
Chemistry and Pharmacology of Neglected Helminthic Diseases
Ausgabe der Zeitschrift
18

Data source: Crossref

Abstract
Neglected helminthic diseases cause many social, economic and health care challenges in developing countries. The high number of patients suffering from these parasitic infections and the lack of sufficient treatment options represent severe problems. Research on new drugs and therapies to meet this urgent requirement has to be intensified. This review focuses on infections caused by four helminthic parasites, which have been declared as neglected diseases by the World Health Organization: namely drancunculiasis, lymphatic filariasis, onchoceriasis, and schistosomiasis. They show a considerable overlap in their world-wide prevalence and treatment strategies. Nevertheless, treatment is not without complications. The most efficient lymphatic filariasis drug, diethylcarbamazine, causes severe adverse effects in onchocerciasis patients and completely fails in the treatment of drancunculiasis. In this review, we discuss these incongruities at the molecular and cellular level. Furthermore, established or investigational drug combination regimens are highlighted. In the past years, progress has been made in the area of schistosomiasis and onchocerciasis. The molecular biology of underlying mechanisms, signalling pathways and related targets affected by drug therapy are discussed in detail. Finally, successful treatment strategies and remaining future challenges are summarized.
Addresses
  • German Cancer Research Center, Pharmaceutical Biology (C015), Heidelberg, Germany.
Autoren
  • A Müllner
  • A Helfer
  • D Kotlyar
  • J Oswald
  • T Efferth
  • T Efferth
DOI
10.2174/092986711794480096
eISSN
1875-533X
Externe Identifier
  • PubMed Identifier: 21182483
Open access
false
ISSN
0929-8673
Ausgabe der Veröffentlichung
5
Zeitschrift
Current medicinal chemistry
Schlüsselwörter
  • Animals
  • Humans
  • Helminths
  • Helminthiasis
  • Dracunculiasis
  • Elephantiasis, Filarial
  • Onchocerciasis
  • Schistosomiasis
  • Anthelmintics
  • Adult
  • Child
  • Neglected Diseases
Sprache
eng
Medium
Print
Paginierung
767 - 789
Datum der Veröffentlichung
2011
Status
Published
Datum der Datenerfassung
2010
Titel
Chemistry and pharmacology of neglected helminthic diseases.
Sub types
  • Research Support, Non-U.S. Gov't
  • Review
  • Journal Article
Ausgabe der Zeitschrift
18

Data source: Europe PubMed Central

Abstract
Neglected helminthic diseases cause many social, economic and health care challenges in developing countries. The high number of patients suffering from these parasitic infections and the lack of sufficient treatment options represent severe problems. Research on new drugs and therapies to meet this urgent requirement has to be intensified. This review focuses on infections caused by four helminthic parasites, which have been declared as neglected diseases by the World Health Organization: namely drancunculiasis, lymphatic filariasis, onchoceriasis, and schistosomiasis. They show a considerable overlap in their world-wide prevalence and treatment strategies. Nevertheless, treatment is not without complications. The most efficient lymphatic filariasis drug, diethylcarbamazine, causes severe adverse effects in onchocerciasis patients and completely fails in the treatment of drancunculiasis. In this review, we discuss these incongruities at the molecular and cellular level. Furthermore, established or investigational drug combination regimens are highlighted. In the past years, progress has been made in the area of schistosomiasis and onchocerciasis. The molecular biology of underlying mechanisms, signalling pathways and related targets affected by drug therapy are discussed in detail. Finally, successful treatment strategies and remaining future challenges are summarized.
Date of acceptance
2010
Autoren
  • A Müllner
  • A Helfer
  • D Kotlyar
  • J Oswald
  • T Efferth
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/21182483
DOI
10.2174/092986711794480096
eISSN
1875-533X
Ausgabe der Veröffentlichung
5
Zeitschrift
Curr Med Chem
Schlüsselwörter
  • Adult
  • Animals
  • Anthelmintics
  • Child
  • Dracunculiasis
  • Elephantiasis, Filarial
  • Helminthiasis
  • Helminths
  • Humans
  • Neglected Diseases
  • Onchocerciasis
  • Schistosomiasis
Sprache
eng
Country
United Arab Emirates
Paginierung
767 - 789
PII
BSP/CMC/E-Pub/2011/ 045
Datum der Veröffentlichung
2011
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2011
Titel
Chemistry and pharmacology of neglected helminthic diseases.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review
Ausgabe der Zeitschrift
18

Data source: PubMed

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