Efficient Lewis Acid Ionic Liquid-Catalyzed Synthesis of the Key Intermediate of Coenzyme Q10 under Microwave Irradiation

Publication type:
Journal article
Metadata:
Autoren
  • Yue Chen
  • Yuangang Zu
  • Yujie Fu
  • Xuan Zhang
  • Ping Yu
  • Guoyong Sun
  • Thomas Efferth
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000285709000065&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.3390/molecules15129486
Externe Identifier
  • Clarivate Analytics Document Solution ID: 700CD
  • PubMed Identifier: 21178903
ISSN
1420-3049
Ausgabe der Veröffentlichung
12
Zeitschrift
MOLECULES
Schlüsselwörter
  • ionic liquids
  • FT-IR
  • acidity
  • microwave irradiation
Paginierung
9486 - 9495
Datum der Veröffentlichung
2010
Status
Published
Titel
Efficient Lewis Acid Ionic Liquid-Catalyzed Synthesis of the Key Intermediate of Coenzyme Q<sub>10</sub> under Microwave Irradiation
Sub types
  • Article
Ausgabe der Zeitschrift
15

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Yue Chen
  • Yuangang Zu
  • Yujie Fu
  • Xuan Zhang
  • Ping Yu
  • Guoyong Sun
  • Thomas Efferth
DOI
10.3390/molecules15129486
eISSN
1420-3049
Ausgabe der Veröffentlichung
12
Zeitschrift
Molecules
Sprache
en
Online publication date
2010
Paginierung
9486 - 9495
Status
Published online
Herausgeber
MDPI AG
Herausgeber URL
http://dx.doi.org/10.3390/molecules15129486
Datum der Datenerfassung
2018
Titel
Efficient Lewis Acid Ionic Liquid-Catalyzed Synthesis of the Key Intermediate of Coenzyme Q10 under Microwave Irradiation
Ausgabe der Zeitschrift
15

Data source: Crossref

Abstract
An efficient synthesis of a valuable intermediate of coenzyme Q(10) by microwave-assisted Lewis acidic ionic liquid (IL)-catalyzed Friedel-Crafts alkylation is reported. The acidity of six [Etpy]BF(4)-based ionic liquids was characterized by means of the FT-IR technique using acetonitrile as a molecular probe. The catalytic activities of these ionic liquids were correlated with their Lewis acidity. With increasing Lewis acid strength of the ionic liquids, their catalytic activity in the Friedel-Crafts reaction increased, except for [Etpy]BF(4)-AlCl(3). The effects of the reaction system, the molar fraction of Lewis acid in the Lewis acid ILs and heating techniques were also investigated. Among the six Lewis acid ionic liquids tested [Etpy]BF(4)-ZnCl(2) showed the best catalytic activity, with a yield of 89% after a very short reaction time (150 seconds). This procedure has the advantages of higher efficiency, better reusability of ILs, energy conservation and eco-friendliness. The method has practical value for preparation of CoQ(10) on an industrial scale.
Addresses
  • Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, China.
Autoren
  • Yue Chen
  • Yuangang Zu
  • Yujie Fu
  • Xuan Zhang
  • Ping Yu
  • Guoyong Sun
  • Thomas Efferth
  • Thomas Efferth
DOI
10.3390/molecules15129486
eISSN
1420-3049
Externe Identifier
  • PubMed Identifier: 21178903
  • PubMed Central ID: PMC6259175
Open access
true
ISSN
1420-3049
Ausgabe der Veröffentlichung
12
Zeitschrift
Molecules (Basel, Switzerland)
Schlüsselwörter
  • Ubiquinone
  • Microwaves
  • Ionic Liquids
  • Lewis Acids
Sprache
eng
Medium
Electronic
Online publication date
2010
Open access status
Open Access
Paginierung
9486 - 9495
Datum der Veröffentlichung
2010
Status
Published
Publisher licence
CC BY
Datum der Datenerfassung
2010
Titel
Efficient Lewis acid ionic liquid-catalyzed synthesis of the key intermediate of coenzyme Q10 under microwave irradiation.
Sub types
  • Research Support, Non-U.S. Gov't
  • research-article
  • Journal Article
Ausgabe der Zeitschrift
15

Files

https://www.mdpi.com/1420-3049/15/12/9486/pdf?version=1403112947 https://europepmc.org/articles/PMC6259175?pdf=render

Data source: Europe PubMed Central

Abstract
An efficient synthesis of a valuable intermediate of coenzyme Q(10) by microwave-assisted Lewis acidic ionic liquid (IL)-catalyzed Friedel-Crafts alkylation is reported. The acidity of six [Etpy]BF(4)-based ionic liquids was characterized by means of the FT-IR technique using acetonitrile as a molecular probe. The catalytic activities of these ionic liquids were correlated with their Lewis acidity. With increasing Lewis acid strength of the ionic liquids, their catalytic activity in the Friedel-Crafts reaction increased, except for [Etpy]BF(4)-AlCl(3). The effects of the reaction system, the molar fraction of Lewis acid in the Lewis acid ILs and heating techniques were also investigated. Among the six Lewis acid ionic liquids tested [Etpy]BF(4)-ZnCl(2) showed the best catalytic activity, with a yield of 89% after a very short reaction time (150 seconds). This procedure has the advantages of higher efficiency, better reusability of ILs, energy conservation and eco-friendliness. The method has practical value for preparation of CoQ(10) on an industrial scale.
Date of acceptance
2010
Autoren
  • Yue Chen
  • Yuangang Zu
  • Yujie Fu
  • Xuan Zhang
  • Ping Yu
  • Guoyong Sun
  • Thomas Efferth
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/21178903
DOI
10.3390/molecules15129486
eISSN
1420-3049
Externe Identifier
  • PubMed Central ID: PMC6259175
Ausgabe der Veröffentlichung
12
Zeitschrift
Molecules
Schlüsselwörter
  • Ionic Liquids
  • Lewis Acids
  • Microwaves
  • Ubiquinone
Sprache
eng
Country
Switzerland
Paginierung
9486 - 9495
PII
molecules15129486
Datum der Veröffentlichung
2010
Status
Published online
Datum, an dem der Datensatz öffentlich gemacht wurde
2011
Titel
Efficient Lewis acid ionic liquid-catalyzed synthesis of the key intermediate of coenzyme Q10 under microwave irradiation.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
15

Data source: PubMed

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