Cytotoxicity of some Cameroonian spices and selected medicinal plant extracts
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Victor Kuete
- Benjamin Krusche
- Mahmoud Youns
- Igor Voukeng
- Aime G Fankam
- Simplice Tankeo
- Stephen Lacmata
- Thomas Efferth
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000289866500028&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1016/j.jep.2011.01.035
- eISSN
- 1872-7573
- Externe Identifier
- Clarivate Analytics Document Solution ID: 754OZ
- PubMed Identifier: 21291988
- ISSN
- 0378-8741
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- JOURNAL OF ETHNOPHARMACOLOGY
- Schlüsselwörter
- Cytotoxicity
- Angiogenesis
- Extracts
- Spices
- Cameroon
- Paginierung
- 803 - 812
- Datum der Veröffentlichung
- 2011
- Status
- Published
- Titel
- Cytotoxicity of some Cameroonian spices and selected medicinal plant extracts
- Sub types
- Article
- Ausgabe der Zeitschrift
- 134
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Victor Kuete
- Benjamin Krusche
- Mahmoud Youns
- Igor Voukeng
- Aimé G Fankam
- Simplice Tankeo
- Stephen Lacmata
- Thomas Efferth
- DOI
- 10.1016/j.jep.2011.01.035
- ISSN
- 0378-8741
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- Journal of Ethnopharmacology
- Sprache
- en
- Paginierung
- 803 - 812
- Datum der Veröffentlichung
- 2011
- Status
- Published
- Herausgeber
- Elsevier BV
- Herausgeber URL
- http://dx.doi.org/10.1016/j.jep.2011.01.035
- Datum der Datenerfassung
- 2020
- Titel
- Cytotoxicity of some Cameroonian spices and selected medicinal plant extracts
- Ausgabe der Zeitschrift
- 134
Data source: Crossref
- Abstract
- <h4>Ethnopharmacological relevance</h4>Several medicinal plants and spices are used traditionally to treat cancers in Cameroon.<h4>Aim</h4>Methanol extracts from thirty-four spices and plants, with related ethnobotanical use were investigated for their in vitro cytotoxicity on the human pancreatic cancer cell line MiaPaCa-2, leukemia CCRF-CEM cells and their multidrug resistant (MDR) subline CEM/ADR5000, and the normal human umbilical vein endothelial cells (HUVECs). In addition the anti-angiogenic properties of the most active extracts were investigated.<h4>Material and methods</h4>The MTS [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium] assay was used for cytotoxic studies and the CAM-assay (chicken-chorioallantoic-membrane-assay) for anti-angiogenesis test.<h4>Results</h4>The results of the cytotoxicity tests indicated that, when tested at 20 μg/ml, extracts from Xylopia aethiopica, Echinops giganteus, Imperata cylindrica, Dorstenia psilirus and Piper capense were able to inhibit more that 50% the proliferation of the three tested cancer cells (MiaPaCa-2, CEM/ADR5000 CCRF-CEM). The lowest IC(50) values of 6.86 μg/ml on MiaPaCa-2 and 3.91 μg/ml on CCRF-CEM cells were obtained with X. aethiopica, while the corresponding value of 6.56 μg/ml was obtained with P. capense on CEM/ADR5000 cells. Against leukemia cells, no cross-resistance was observed with I. cylindrica, P. capense and Zinziber officinalis. Extracts from D. psilirus and E. giganteus were able to inhibit angiogenesis by more than 50% in quail embryo.<h4>Conclusion</h4>The overall results of the present study provide supportive data on the use of some Cameroonian plants for cancer treatment.
- Addresses
- Department of Biochemistry, Faculty of Science, University of Dschang, Cameroon.
- Autoren
- Victor Kuete
- Benjamin Krusche
- Mahmoud Youns
- Igor Voukeng
- Aimé G Fankam
- Simplice Tankeo
- Stephen Lacmata
- Thomas Efferth
- Thomas Efferth
- DOI
- 10.1016/j.jep.2011.01.035
- eISSN
- 1872-7573
- Externe Identifier
- PubMed Identifier: 21291988
- Funding acknowledgements
- the National Herbarium of Cameroon (Yaounde):
- Open access
- false
- ISSN
- 0378-8741
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- Journal of ethnopharmacology
- Schlüsselwörter
- Cells, Cultured
- Cell Line, Tumor
- Humans
- Plants, Medicinal
- Pancreatic Neoplasms
- Angiogenesis Inhibitors
- Plant Extracts
- Antineoplastic Agents, Phytogenic
- Drug Screening Assays, Antitumor
- Spices
- Cameroon
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2011
- Paginierung
- 803 - 812
- Datum der Veröffentlichung
- 2011
- Status
- Published
- Datum der Datenerfassung
- 2011
- Titel
- Cytotoxicity of some Cameroonian spices and selected medicinal plant extracts.
- Sub types
- Research Support, Non-U.S. Gov't
- Journal Article
- Ausgabe der Zeitschrift
- 134
Data source: Europe PubMed Central
- Abstract
- ETHNOPHARMACOLOGICAL RELEVANCE: Several medicinal plants and spices are used traditionally to treat cancers in Cameroon. AIM: Methanol extracts from thirty-four spices and plants, with related ethnobotanical use were investigated for their in vitro cytotoxicity on the human pancreatic cancer cell line MiaPaCa-2, leukemia CCRF-CEM cells and their multidrug resistant (MDR) subline CEM/ADR5000, and the normal human umbilical vein endothelial cells (HUVECs). In addition the anti-angiogenic properties of the most active extracts were investigated. MATERIAL AND METHODS: The MTS [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium] assay was used for cytotoxic studies and the CAM-assay (chicken-chorioallantoic-membrane-assay) for anti-angiogenesis test. RESULTS: The results of the cytotoxicity tests indicated that, when tested at 20 μg/ml, extracts from Xylopia aethiopica, Echinops giganteus, Imperata cylindrica, Dorstenia psilirus and Piper capense were able to inhibit more that 50% the proliferation of the three tested cancer cells (MiaPaCa-2, CEM/ADR5000 CCRF-CEM). The lowest IC(50) values of 6.86 μg/ml on MiaPaCa-2 and 3.91 μg/ml on CCRF-CEM cells were obtained with X. aethiopica, while the corresponding value of 6.56 μg/ml was obtained with P. capense on CEM/ADR5000 cells. Against leukemia cells, no cross-resistance was observed with I. cylindrica, P. capense and Zinziber officinalis. Extracts from D. psilirus and E. giganteus were able to inhibit angiogenesis by more than 50% in quail embryo. CONCLUSION: The overall results of the present study provide supportive data on the use of some Cameroonian plants for cancer treatment.
- Date of acceptance
- 2011
- Autoren
- Victor Kuete
- Benjamin Krusche
- Mahmoud Youns
- Igor Voukeng
- Aimé G Fankam
- Simplice Tankeo
- Stephen Lacmata
- Thomas Efferth
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/21291988
- DOI
- 10.1016/j.jep.2011.01.035
- eISSN
- 1872-7573
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- J Ethnopharmacol
- Schlüsselwörter
- Angiogenesis Inhibitors
- Antineoplastic Agents, Phytogenic
- Cameroon
- Cell Line, Tumor
- Cells, Cultured
- Drug Screening Assays, Antitumor
- Humans
- Pancreatic Neoplasms
- Plant Extracts
- Plants, Medicinal
- Spices
- Sprache
- eng
- Country
- Ireland
- Paginierung
- 803 - 812
- PII
- S0378-8741(11)00049-3
- Datum der Veröffentlichung
- 2011
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2011
- Titel
- Cytotoxicity of some Cameroonian spices and selected medicinal plant extracts.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 134
Data source: PubMed
- Beziehungen:
- Property of