Chemical Composition and Antiproliferative Activity of Essential Oil from the Leaves of a Medicinal Herb, Levisticum officinale, against UMSCC1 Head and Neck Squamous Carcinoma Cells

Publication type:
Journal article
Metadata:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000286798000024&DestLinkType=FullRecord&DestApp=WOS_CPL
eISSN
1791-7530
Externe Identifier
  • Clarivate Analytics Document Solution ID: 714HI
  • PubMed Identifier: 21273597
ISSN
0250-7005
Ausgabe der Veröffentlichung
1
Zeitschrift
ANTICANCER RESEARCH
Schlüsselwörter
  • Levisticum officinale lovage
  • oral cavity squamous cell carcinoma OCSCC
  • head and neck squamous cell carcinoma HNSCC
  • natural product
  • pharmacogenomics
Paginierung
185 - 191
Datum der Veröffentlichung
2011
Status
Published
Titel
Chemical Composition and Antiproliferative Activity of Essential Oil from the Leaves of a Medicinal Herb, <i>Levisticum officinale</i>, against UMSCC1 Head and Neck Squamous Carcinoma Cells
Sub types
  • Article
Ausgabe der Zeitschrift
31

Data source: Web of Science (Lite)

Other metadata sources:
Abstract
<h4>Background</h4>Oral squamous cell carcinoma (OSCC) is a challenging disease with a high mortality rate. Natural products represent a valuable source for the development of novel anticancer drugs. We investigated the cytotoxic potential of essential oil from the leaves of a medicinal plant, Levisticum officinale (lovage) on head and neck squamous carcinoma cells (HNSCC).<h4>Materials and methods</h4>Cytotoxicity of lovage essential oil was investigated on the HNSCC cell line, UMSCC1. Additionally, we performed pharmacogenomics analyses.<h4>Results</h4>Lovage essential oil extract had an IC₅₀ value of 292.6 μg/ml. Genes involved in apoptosis, cancer, cellular growth and cell cycle regulation were the most prominently affected in microarray analyses. The three pathways to be most significantly regulated were extracellular signal-regulated kinase 5 (ERK5) signaling, integrin-linked kinase (ILK) signaling, virus entry via endocytic pathways and p53 signaling.<h4>Conclusion</h4>Levisticum officinale essential oil inhibits human HNSCC cell growth.
Addresses
  • Department of Otorhinolaryngology, Head and Neck Surgery, University of Heidelberg, Heidelberg, Germany.
Autoren
eISSN
1791-7530
Externe Identifier
  • PubMed Identifier: 21273597
Open access
false
ISSN
0250-7005
Ausgabe der Veröffentlichung
1
Zeitschrift
Anticancer research
Schlüsselwörter
  • Tumor Cells, Cultured
  • Humans
  • Levisticum
  • Plant Leaves
  • Plants, Medicinal
  • Carcinoma, Squamous Cell
  • Head and Neck Neoplasms
  • Plant Oils
  • Chromatography, Gas
  • Oligonucleotide Array Sequence Analysis
  • Gene Expression Profiling
  • Apoptosis
  • Cell Proliferation
  • Biomarkers, Tumor
Sprache
eng
Medium
Print
Paginierung
185 - 191
Datum der Veröffentlichung
2011
Status
Published
Datum der Datenerfassung
2011
Titel
Chemical Composition and antiproliferative activity of essential oil from the leaves of a medicinal herb, Levisticum officinale, against UMSCC1 head and neck squamous carcinoma cells.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
31

Data source: Europe PubMed Central

Abstract
BACKGROUND: Oral squamous cell carcinoma (OSCC) is a challenging disease with a high mortality rate. Natural products represent a valuable source for the development of novel anticancer drugs. We investigated the cytotoxic potential of essential oil from the leaves of a medicinal plant, Levisticum officinale (lovage) on head and neck squamous carcinoma cells (HNSCC). MATERIALS AND METHODS: Cytotoxicity of lovage essential oil was investigated on the HNSCC cell line, UMSCC1. Additionally, we performed pharmacogenomics analyses. RESULTS: Lovage essential oil extract had an IC₅₀ value of 292.6 μg/ml. Genes involved in apoptosis, cancer, cellular growth and cell cycle regulation were the most prominently affected in microarray analyses. The three pathways to be most significantly regulated were extracellular signal-regulated kinase 5 (ERK5) signaling, integrin-linked kinase (ILK) signaling, virus entry via endocytic pathways and p53 signaling. CONCLUSION: Levisticum officinale essential oil inhibits human HNSCC cell growth.
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/21273597
eISSN
1791-7530
Ausgabe der Veröffentlichung
1
Zeitschrift
Anticancer Res
Schlüsselwörter
  • Apoptosis
  • Biomarkers, Tumor
  • Carcinoma, Squamous Cell
  • Cell Proliferation
  • Chromatography, Gas
  • Gene Expression Profiling
  • Head and Neck Neoplasms
  • Humans
  • Levisticum
  • Oligonucleotide Array Sequence Analysis
  • Plant Leaves
  • Plant Oils
  • Plants, Medicinal
  • Tumor Cells, Cultured
Sprache
eng
Country
Greece
Paginierung
185 - 191
PII
31/1/185
Datum der Veröffentlichung
2011
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2011
Titel
Chemical Composition and antiproliferative activity of essential oil from the leaves of a medicinal herb, Levisticum officinale, against UMSCC1 head and neck squamous carcinoma cells.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
31

Data source: PubMed

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