Cytotoxicity of Thymus vulgaris Essential Oil Towards Human Oral Cavity Squamous Cell Carcinoma

Publication type:
Journal article
Metadata:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000286798000011&DestLinkType=FullRecord&DestApp=WOS_CPL
eISSN
1791-7530
Externe Identifier
  • Clarivate Analytics Document Solution ID: 714HI
  • PubMed Identifier: 21273584
ISSN
0250-7005
Ausgabe der Veröffentlichung
1
Zeitschrift
ANTICANCER RESEARCH
Schlüsselwörter
  • Thymus vulgaris L. (thyme)
  • oral cavity squamous cell carcinoma OCSCC
  • head and neck squamous cell carcinoma HNSCC
  • natural product
  • pharmacogenomics
Paginierung
81 - 87
Datum der Veröffentlichung
2011
Status
Published
Titel
Cytotoxicity of <i>Thymus vulgaris</i> Essential Oil Towards Human Oral Cavity Squamous Cell Carcinoma
Sub types
  • Article
Ausgabe der Zeitschrift
31

Data source: Web of Science (Lite)

Other metadata sources:
Abstract
<h4>Background</h4>Oral cavity squamous cell carcinoma (OCSCC) accounts for 2% to 3% of all malignancies and has a high mortality rate. The majority of anticancer drugs are of natural origin. However, it is unknown whether the medicinal plant Thymus vulgaris L. (thyme) is cytotoxic towards head and neck squamous cell carcinoma (HNSCC).<h4>Materials and methods</h4>Cytotoxicity of thyme essential oil was investigated on the HNSCC cell line, UMSCC1. The IC₅₀ of thyme essential oil extract was 369 μg/ml. Moreover, we performed pharmacogenomics analyses.<h4>Results</h4>Genes involved in the cell cycle, cell death and cancer were involved in the cytotoxic activity of thyme essential oil at the transcriptional level. The three most significantly regulated pathways by thyme essential oil were interferon signaling, N-glycan biosynthesis and extracellular signal-regulated kinase 5 (ERK5) signaling.<h4>Conclusion</h4>Thyme essential oil inhibits human HNSCC cell growth. Based on pharmacogenomic approaches, novel insights into the molecular mode of anticancer activity of thyme are presented.
Addresses
  • Department of Otorhinolaryngology, Head and Neck Surgery, University of Heidelberg, Heidelberg, Germany.
Autoren
eISSN
1791-7530
Externe Identifier
  • PubMed Identifier: 21273584
Open access
false
ISSN
0250-7005
Ausgabe der Veröffentlichung
1
Zeitschrift
Anticancer research
Schlüsselwörter
  • Tumor Cells, Cultured
  • Humans
  • Thymus Plant
  • Carcinoma, Squamous Cell
  • Mouth Neoplasms
  • Mitogen-Activated Protein Kinase 7
  • Oils, Volatile
  • Interferons
  • RNA, Messenger
  • Phytotherapy
  • Oligonucleotide Array Sequence Analysis
  • Gene Expression Profiling
  • Reverse Transcriptase Polymerase Chain Reaction
  • Signal Transduction
  • Apoptosis
  • Biomarkers, Tumor
Sprache
eng
Medium
Print
Paginierung
81 - 87
Datum der Veröffentlichung
2011
Status
Published
Datum der Datenerfassung
2011
Titel
Cytotoxicity of Thymus vulgaris essential oil towards human oral cavity squamous cell carcinoma.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
31

Data source: Europe PubMed Central

Abstract
BACKGROUND: Oral cavity squamous cell carcinoma (OCSCC) accounts for 2% to 3% of all malignancies and has a high mortality rate. The majority of anticancer drugs are of natural origin. However, it is unknown whether the medicinal plant Thymus vulgaris L. (thyme) is cytotoxic towards head and neck squamous cell carcinoma (HNSCC). MATERIALS AND METHODS: Cytotoxicity of thyme essential oil was investigated on the HNSCC cell line, UMSCC1. The IC₅₀ of thyme essential oil extract was 369 μg/ml. Moreover, we performed pharmacogenomics analyses. RESULTS: Genes involved in the cell cycle, cell death and cancer were involved in the cytotoxic activity of thyme essential oil at the transcriptional level. The three most significantly regulated pathways by thyme essential oil were interferon signaling, N-glycan biosynthesis and extracellular signal-regulated kinase 5 (ERK5) signaling. CONCLUSION: Thyme essential oil inhibits human HNSCC cell growth. Based on pharmacogenomic approaches, novel insights into the molecular mode of anticancer activity of thyme are presented.
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/21273584
eISSN
1791-7530
Ausgabe der Veröffentlichung
1
Zeitschrift
Anticancer Res
Schlüsselwörter
  • Apoptosis
  • Biomarkers, Tumor
  • Carcinoma, Squamous Cell
  • Gene Expression Profiling
  • Humans
  • Interferons
  • Mitogen-Activated Protein Kinase 7
  • Mouth Neoplasms
  • Oils, Volatile
  • Oligonucleotide Array Sequence Analysis
  • Phytotherapy
  • RNA, Messenger
  • Reverse Transcriptase Polymerase Chain Reaction
  • Signal Transduction
  • Thymus Plant
  • Tumor Cells, Cultured
Sprache
eng
Country
Greece
Paginierung
81 - 87
PII
31/1/81
Datum der Veröffentlichung
2011
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2011
Titel
Cytotoxicity of Thymus vulgaris essential oil towards human oral cavity squamous cell carcinoma.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
31

Data source: PubMed

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