Human cytomegalovirus kinetics following institution of artesunate after hematopoietic stem cell transplantation

Publication type:
Journal article
Metadata:
Autoren
  • Dana G Wolf
  • Avichai Shimoni
  • Igor B Resnick
  • Thomas Stamminger
  • Avidan U Neumann
  • Sunwen Chou
  • Thomas Efferth
  • Orit Caplan
  • Jessica Rose
  • Arnon Nagler
  • Manfred Marschall
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000291912500011&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.antiviral.2011.03.184
Externe Identifier
  • Clarivate Analytics Document Solution ID: 781ED
  • PubMed Identifier: 21443904
ISSN
0166-3542
Ausgabe der Veröffentlichung
3
Zeitschrift
ANTIVIRAL RESEARCH
Schlüsselwörter
  • Cytomegalovirus
  • Artesunate
  • Antiviral drugs
  • Viral kinetics
Paginierung
183 - 186
Datum der Veröffentlichung
2011
Status
Published
Titel
Human cytomegalovirus kinetics following institution of artesunate after hematopoietic stem cell transplantation
Sub types
  • Article
Ausgabe der Zeitschrift
90

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Dana G Wolf
  • Avichai Shimoni
  • Igor B Resnick
  • Thomas Stamminger
  • Avidan U Neumann
  • Sunwen Chou
  • Thomas Efferth
  • Orit Caplan
  • Jessica Rose
  • Arnon Nagler
  • Manfred Marschall
DOI
10.1016/j.antiviral.2011.03.184
ISSN
0166-3542
Ausgabe der Veröffentlichung
3
Zeitschrift
Antiviral Research
Sprache
en
Paginierung
183 - 186
Datum der Veröffentlichung
2011
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.antiviral.2011.03.184
Datum der Datenerfassung
2018
Titel
Human cytomegalovirus kinetics following institution of artesunate after hematopoietic stem cell transplantation
Ausgabe der Zeitschrift
90

Data source: Crossref

Abstract
The anti-malaria drug artesunate has been shown to be an effective inhibitor of cytomegalovirus (CMV) in vitro, in an experimental animal model, and in a recent single-case clinical use. In this first case-series of 6 stem cell transplant recipients who received preemptive artesunate treatment for CMV infection, we have examined the viral kinetics following institution of artesunate, and employed first-phase viral kinetics studies to calculate its antiviral effectiveness. Two patients demonstrated a rapid 0.8-2.1 log viral load decline by 7 days, with a viral decay half-live of 0.9-1.9 days. Four patients demonstrated a continued yet stalled viral growth slope during treatment. No adverse events were noted in treatment courses of up to 28 days. Overall, a divergent antiviral efficacy was revealed, ranging from 43% to 90%, which appeared to be primarily dependent on the virus baseline growth dynamics. Further dose escalation studies are needed to examine the role of artesunate in the treatment of CMV infection in the transplantation setting.
Addresses
  • Clinical Virology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel. dana.wolf@ekmd.huji.ac.il
Autoren
  • Dana G Wolf
  • Avichai Shimoni
  • Igor B Resnick
  • Thomas Stamminger
  • Avidan U Neumann
  • Sunwen Chou
  • Thomas Efferth
  • Thomas Efferth
  • Orit Caplan
  • Jessica Rose
  • Arnon Nagler
  • Manfred Marschall
DOI
10.1016/j.antiviral.2011.03.184
eISSN
1872-9096
Externe Identifier
  • PubMed Identifier: 21443904
  • PubMed Central ID: PMC3253856
Funding acknowledgements
  • NIAID NIH HHS: R01 AI039938
  • NIAID NIH HHS: R01 AI039938-14
  • NIAID NIH HHS: AI39938
Open access
false
ISSN
0166-3542
Ausgabe der Veröffentlichung
3
Zeitschrift
Antiviral research
Schlüsselwörter
  • Humans
  • Cytomegalovirus
  • Cytomegalovirus Infections
  • Artemisinins
  • Antiviral Agents
  • Hematopoietic Stem Cell Transplantation
  • Viral Load
  • Kinetics
  • Adult
  • Aged
  • Middle Aged
  • Child
  • Female
  • Male
  • Artesunate
Sprache
eng
Medium
Print-Electronic
Online publication date
2011
Paginierung
183 - 186
Datum der Veröffentlichung
2011
Status
Published
Datum der Datenerfassung
2011
Titel
Human cytomegalovirus kinetics following institution of artesunate after hematopoietic stem cell transplantation.
Sub types
  • Research Support, Non-U.S. Gov't
  • research-article
  • Journal Article
  • Case Reports
  • Research Support, N.I.H., Extramural
Ausgabe der Zeitschrift
90

Files

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21443904/pdf/?tool=EBI https://europepmc.org/articles/PMC3253856?pdf=render

Data source: Europe PubMed Central

Abstract
The anti-malaria drug artesunate has been shown to be an effective inhibitor of cytomegalovirus (CMV) in vitro, in an experimental animal model, and in a recent single-case clinical use. In this first case-series of 6 stem cell transplant recipients who received preemptive artesunate treatment for CMV infection, we have examined the viral kinetics following institution of artesunate, and employed first-phase viral kinetics studies to calculate its antiviral effectiveness. Two patients demonstrated a rapid 0.8-2.1 log viral load decline by 7 days, with a viral decay half-live of 0.9-1.9 days. Four patients demonstrated a continued yet stalled viral growth slope during treatment. No adverse events were noted in treatment courses of up to 28 days. Overall, a divergent antiviral efficacy was revealed, ranging from 43% to 90%, which appeared to be primarily dependent on the virus baseline growth dynamics. Further dose escalation studies are needed to examine the role of artesunate in the treatment of CMV infection in the transplantation setting.
Date of acceptance
2011
Autoren
  • Dana G Wolf
  • Avichai Shimoni
  • Igor B Resnick
  • Thomas Stamminger
  • Avidan U Neumann
  • Sunwen Chou
  • Thomas Efferth
  • Orit Caplan
  • Jessica Rose
  • Arnon Nagler
  • Manfred Marschall
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/21443904
DOI
10.1016/j.antiviral.2011.03.184
eISSN
1872-9096
Externe Identifier
  • NIH Manuscript Submission ID: NIHMS344081
  • PubMed Central ID: PMC3253856
Funding acknowledgements
  • NIAID NIH HHS: R01 AI039938
  • NIAID NIH HHS: R01 AI039938-14
  • NIAID NIH HHS: AI39938
Ausgabe der Veröffentlichung
3
Zeitschrift
Antiviral Res
Schlüsselwörter
  • Adult
  • Aged
  • Antiviral Agents
  • Artemisinins
  • Artesunate
  • Child
  • Cytomegalovirus
  • Cytomegalovirus Infections
  • Female
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Kinetics
  • Male
  • Middle Aged
  • Viral Load
Sprache
eng
Country
Netherlands
Paginierung
183 - 186
PII
S0166-3542(11)00236-1
Datum der Veröffentlichung
2011
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2011
Titel
Human cytomegalovirus kinetics following institution of artesunate after hematopoietic stem cell transplantation.
Sub types
  • Case Reports
  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
90

Data source: PubMed

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