Pharmacogenomics of Cameroonian traditional herbal medicine for cancer therapy

Publication type:
Journal article
Metadata:
Autoren
  • Victor Kuete
  • Thomas Efferth
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000295236700088&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.jep.2011.06.035
eISSN
1872-7573
Externe Identifier
  • Clarivate Analytics Document Solution ID: 824XY
  • PubMed Identifier: 21763411
ISSN
0378-8741
Ausgabe der Veröffentlichung
1
Zeitschrift
JOURNAL OF ETHNOPHARMACOLOGY
Schlüsselwörter
  • Africa
  • Cytotoxicity
  • Microarray
  • Natural products
  • Pharmacogenomics
Paginierung
752 - 766
Datum der Veröffentlichung
2011
Status
Published
Titel
Pharmacogenomics of Cameroonian traditional herbal medicine for cancer therapy
Sub types
  • Article
Ausgabe der Zeitschrift
137

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Victor Kuete
  • Thomas Efferth
DOI
10.1016/j.jep.2011.06.035
ISSN
0378-8741
Ausgabe der Veröffentlichung
1
Zeitschrift
Journal of Ethnopharmacology
Sprache
en
Paginierung
752 - 766
Datum der Veröffentlichung
2011
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.jep.2011.06.035
Datum der Datenerfassung
2018
Titel
Pharmacogenomics of Cameroonian traditional herbal medicine for cancer therapy
Ausgabe der Zeitschrift
137

Data source: Crossref

Abstract
<h4>Ethnopharmacological relevance</h4>A socio-economic burden associated with cancers is reported in Africa. Ethnopharmacological usages such as immune and skin disorders, inflammatory, and others chould be considered when selecting plants used to treat cancer, since these reflect disease states bearing relevance to cancer or a cancer symptoms.<h4>Materials and methods</h4>Documented compounds of Cameroonian medicinal plants were used as keywords in the National Cancer Institute (NCI) database to establish a library of cytotoxic compounds. Cellular and pharmacogenomic profiling was then performed for the 10 most cytotoxic natural products. By COMPARE and hierarchical cluster analyses, candidate genes were identified whose mRNA expression significantly predicted sensitivity or resistance of cell lines to the two most cytotoxic compounds.<h4>Results</h4>Up to 974 compounds isolated from 148 medicinal plants were used as keywords in the NCI database to establish a library of 27 cytotoxic compounds. Two of the 10 most cytotoxic compounds, plumericin from Plumeria rubra and plumbagin from Diospyros crassiflora and Diospyros canaliculata, were analyzed in more detail. The IC(50) values for plumericin and plumbagin of 60 NCI cell lines were associated with the microarray-based transcriptome-wide mRNA expression. Genes products identified for plumericin activity are mainly involved in enzymatic activity, transcriptional processes or are structural constituents of ribosomes. Products identified for plumbagin activity are involved in several processes, but they are mostly the strucrural constituents of ribosomes or involved in enzymatic activity.<h4>Conclusions</h4>The most significant progress of the present investigation, the first of its kind ever reported for investigated natural product in Sub-Saharan Africa, was the connection between traditionally used medicinal plants and the mechanistic analysis, such as pharmacogenomics.
Addresses
  • Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box. 67, Dschang, Cameroon.
Autoren
DOI
10.1016/j.jep.2011.06.035
eISSN
1872-7573
Externe Identifier
  • PubMed Identifier: 21763411
Open access
false
ISSN
0378-8741
Ausgabe der Veröffentlichung
1
Zeitschrift
Journal of ethnopharmacology
Schlüsselwörter
  • Cell Line, Tumor
  • Animals
  • Humans
  • Plants, Medicinal
  • RNA, Messenger
  • Plant Preparations
  • Antineoplastic Agents, Phytogenic
  • Medicine, African Traditional
  • Cluster Analysis
  • Gene Expression Profiling
  • Inhibitory Concentration 50
  • Pharmacogenetics
  • Cell Survival
  • Gene Expression Regulation, Neoplastic
  • Dose-Response Relationship, Drug
  • Drug Resistance, Neoplasm
  • Cameroon
Sprache
eng
Medium
Print-Electronic
Online publication date
2011
Paginierung
752 - 766
Datum der Veröffentlichung
2011
Status
Published
Datum der Datenerfassung
2011
Titel
Pharmacogenomics of Cameroonian traditional herbal medicine for cancer therapy.
Sub types
  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Journal Article
Ausgabe der Zeitschrift
137

Data source: Europe PubMed Central

Abstract
ETHNOPHARMACOLOGICAL RELEVANCE: A socio-economic burden associated with cancers is reported in Africa. Ethnopharmacological usages such as immune and skin disorders, inflammatory, and others chould be considered when selecting plants used to treat cancer, since these reflect disease states bearing relevance to cancer or a cancer symptoms. MATERIALS AND METHODS: Documented compounds of Cameroonian medicinal plants were used as keywords in the National Cancer Institute (NCI) database to establish a library of cytotoxic compounds. Cellular and pharmacogenomic profiling was then performed for the 10 most cytotoxic natural products. By COMPARE and hierarchical cluster analyses, candidate genes were identified whose mRNA expression significantly predicted sensitivity or resistance of cell lines to the two most cytotoxic compounds. RESULTS: Up to 974 compounds isolated from 148 medicinal plants were used as keywords in the NCI database to establish a library of 27 cytotoxic compounds. Two of the 10 most cytotoxic compounds, plumericin from Plumeria rubra and plumbagin from Diospyros crassiflora and Diospyros canaliculata, were analyzed in more detail. The IC(50) values for plumericin and plumbagin of 60 NCI cell lines were associated with the microarray-based transcriptome-wide mRNA expression. Genes products identified for plumericin activity are mainly involved in enzymatic activity, transcriptional processes or are structural constituents of ribosomes. Products identified for plumbagin activity are involved in several processes, but they are mostly the strucrural constituents of ribosomes or involved in enzymatic activity. CONCLUSIONS: The most significant progress of the present investigation, the first of its kind ever reported for investigated natural product in Sub-Saharan Africa, was the connection between traditionally used medicinal plants and the mechanistic analysis, such as pharmacogenomics.
Date of acceptance
2011
Autoren
  • Victor Kuete
  • Thomas Efferth
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/21763411
DOI
10.1016/j.jep.2011.06.035
eISSN
1872-7573
Ausgabe der Veröffentlichung
1
Zeitschrift
J Ethnopharmacol
Schlüsselwörter
  • Animals
  • Antineoplastic Agents, Phytogenic
  • Cameroon
  • Cell Line, Tumor
  • Cell Survival
  • Cluster Analysis
  • Dose-Response Relationship, Drug
  • Drug Resistance, Neoplasm
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Inhibitory Concentration 50
  • Medicine, African Traditional
  • Pharmacogenetics
  • Plant Preparations
  • Plants, Medicinal
  • RNA, Messenger
Sprache
eng
Country
Ireland
Paginierung
752 - 766
PII
S0378-8741(11)00463-6
Datum der Veröffentlichung
2011
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2011
Titel
Pharmacogenomics of Cameroonian traditional herbal medicine for cancer therapy.
Sub types
  • Comparative Study
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
137

Data source: PubMed

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