P-glycoprotein and its inhibition in tumors by phytochemicals derived from Chinese herbs
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Tolga Eichhorn
- Thomas Efferth
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000305201100003&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1016/j.jep.2011.08.053
- eISSN
- 1872-7573
- Externe Identifier
- Clarivate Analytics Document Solution ID: 957XT
- PubMed Identifier: 21963565
- ISSN
- 0378-8741
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- JOURNAL OF ETHNOPHARMACOLOGY
- Schlüsselwörter
- Cancer
- Chemotherapy
- Multidrug resistance
- Pharmacognosy
- Phytochemistry
- Paginierung
- 557 - 570
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Titel
- P-glycoprotein and its inhibition in tumors by phytochemicals derived from Chinese herbs
- Sub types
- Review
- Ausgabe der Zeitschrift
- 141
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Tolga Eichhorn
- Thomas Efferth
- DOI
- 10.1016/j.jep.2011.08.053
- ISSN
- 0378-8741
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- Journal of Ethnopharmacology
- Sprache
- en
- Paginierung
- 557 - 570
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Herausgeber
- Elsevier BV
- Herausgeber URL
- http://dx.doi.org/10.1016/j.jep.2011.08.053
- Datum der Datenerfassung
- 2021
- Titel
- P-glycoprotein and its inhibition in tumors by phytochemicals derived from Chinese herbs
- Ausgabe der Zeitschrift
- 141
Data source: Crossref
- Abstract
- P-glycoprotein belongs to the family of ATP-binding cassette (ABC) transporters. It functions in cellular detoxification, pumping a wide range of xenobiotic compounds, including anticancer drugs out of the cell. In cancerous cells, P-glycoprotein confers resistance to a broad spectrum of anticancer agents, a phenomenon termed multidrug resistance. An attractive strategy for overcoming multidrug resistance is to block the transport function of P-glycoprotein and thus increase intracellular concentrations of anticancer drugs to lethal levels. Efforts to identify P-glycoprotein inhibitors have led to numerous candidates, none of which have passed clinical trials with cancer patients due to their high toxicity. The search for naturally inhibitory products from traditional Chinese medicine may be more promising because natural products are frequently less toxic than chemically synthesized substances. In this review, we give an overview of molecular and clinical aspects of P-glycoprotein and multidrug resistance in the context of cancer as well as Chinese herbs and phytochemicals showing inhibitory activity towards P-glycoprotein.
- Addresses
- Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany.
- Autoren
- Tolga Eichhorn
- Thomas Efferth
- Thomas Efferth
- DOI
- 10.1016/j.jep.2011.08.053
- eISSN
- 1872-7573
- Externe Identifier
- PubMed Identifier: 21963565
- Open access
- false
- ISSN
- 0378-8741
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- Journal of ethnopharmacology
- Schlüsselwörter
- Animals
- Humans
- Plants, Medicinal
- Neoplasms
- Drugs, Chinese Herbal
- Antineoplastic Agents, Phytogenic
- Drug Resistance, Neoplasm
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2011
- Paginierung
- 557 - 570
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Datum der Datenerfassung
- 2011
- Titel
- P-glycoprotein and its inhibition in tumors by phytochemicals derived from Chinese herbs.
- Sub types
- Review
- Journal Article
- Ausgabe der Zeitschrift
- 141
Data source: Europe PubMed Central
- Abstract
- P-glycoprotein belongs to the family of ATP-binding cassette (ABC) transporters. It functions in cellular detoxification, pumping a wide range of xenobiotic compounds, including anticancer drugs out of the cell. In cancerous cells, P-glycoprotein confers resistance to a broad spectrum of anticancer agents, a phenomenon termed multidrug resistance. An attractive strategy for overcoming multidrug resistance is to block the transport function of P-glycoprotein and thus increase intracellular concentrations of anticancer drugs to lethal levels. Efforts to identify P-glycoprotein inhibitors have led to numerous candidates, none of which have passed clinical trials with cancer patients due to their high toxicity. The search for naturally inhibitory products from traditional Chinese medicine may be more promising because natural products are frequently less toxic than chemically synthesized substances. In this review, we give an overview of molecular and clinical aspects of P-glycoprotein and multidrug resistance in the context of cancer as well as Chinese herbs and phytochemicals showing inhibitory activity towards P-glycoprotein.
- Date of acceptance
- 2011
- Autoren
- Tolga Eichhorn
- Thomas Efferth
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/21963565
- DOI
- 10.1016/j.jep.2011.08.053
- eISSN
- 1872-7573
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- J Ethnopharmacol
- Schlüsselwörter
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Antineoplastic Agents, Phytogenic
- Drug Resistance, Neoplasm
- Drugs, Chinese Herbal
- Humans
- Neoplasms
- Plants, Medicinal
- Sprache
- eng
- Country
- Ireland
- Paginierung
- 557 - 570
- PII
- S0378-8741(11)00626-X
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2012
- Titel
- P-glycoprotein and its inhibition in tumors by phytochemicals derived from Chinese herbs.
- Sub types
- Journal Article
- Review
- Ausgabe der Zeitschrift
- 141
Data source: PubMed
- Beziehungen:
- Property of