Anticancer activity of Salvia officinalis essential oil against HNSCC cell line (UMSCC1)

Publication type:
Journal article
Metadata:
Autoren
  • S Sertel
  • T Eichhorn
  • PK Plinkert
  • T Efferth
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000297867900008&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1007/s00106-011-2274-3
Externe Identifier
  • Clarivate Analytics Document Solution ID: 859HQ
  • PubMed Identifier: 21894557
ISSN
0017-6192
Ausgabe der Veröffentlichung
12
Zeitschrift
HNO
Schlüsselwörter
  • Mouth neoplasms
  • Salvia officinalis
  • Plant oils
  • Cytotoxicity
  • Microarray analysis
Paginierung
1203 - 1208
Datum der Veröffentlichung
2011
Status
Published
Titel
Anticancer activity of Salvia officinalis essential oil against HNSCC cell line (UMSCC1)
Sub types
  • Article
Ausgabe der Zeitschrift
59

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • S Sertel
  • T Eichhorn
  • PK Plinkert
  • T Efferth
DOI
10.1007/s00106-011-2274-3
eISSN
1433-0458
ISSN
0017-6192
Ausgabe der Veröffentlichung
12
Zeitschrift
HNO
Sprache
de
Online publication date
2011
Paginierung
1203 - 1208
Datum der Veröffentlichung
2011
Status
Published
Herausgeber
Springer Science and Business Media LLC
Herausgeber URL
http://dx.doi.org/10.1007/s00106-011-2274-3
Datum der Datenerfassung
2019
Titel
Krebshemmende Wirkung des ätherischen Salbei-Öls auf eine Plattenepithelzellkarzinom-Zelllinie der Mundhöhle (UMSCC1)
Ausgabe der Zeitschrift
59

Data source: Crossref

Abstract
<h4>Background</h4>Every year there are several hundred thousand new cases of oral cancer worldwide. Clinical oncology is still challenged by toxicity and side effects of multimodal therapy strategies in which is associated with poor prognosis for patients. There is an urgent necessity to develop novel therapy strategies. As the majority of anticancer drugs are of natural origin, natural products represent a valuable source for the identification and development of novel treatment options for cancer. The aim of this investigation was to study the cytotoxicity of Salvia officinalis L. (sage) essential oil.<h4>Methods</h4>Salvia officinalis essential oil was gained by aqueous extraction from plant material and subsequently analyzed by gas chromatography. The cytotoxicity of the essential oil on the squamous human cell carcinoma cell line of the oral cavity (UMSCC1) was assessed with the XTT assay. These experiments revealed the half maximal inhibitory concentration (IC(50)) of the essential oil. It was used in the microarray-based analysis of gene expression of UMSSC1 cells. The results were submitted to a signaling pathway analysis.<h4>Results</h4>The main constituents of Salvia officinalis essential oil include the monoterpenes thujone, β-pinene, and 1,8-cineol. Low concentrations of the essential oil increased vitality of the UMSCC1 cells. Beyond the concentration of the IC(50) of 135 µg/ml, sage essential oil reduced UMSSC1 cells viability to a minimum. In the microarray gene expression analysis, genes involved in cancer, cellular growth and proliferation, cell death, cell morphology, cell cycle, gene expression, and DNA repair were the most prominent. The three most significantly regulated pathways by sage were aryl hydrocarbon receptor signaling, cell cycle (G1/S checkpoint) regulation, and p53 signaling.<h4>Conclusion</h4>To the best of our knowledge, this study suggests for the first time the ability of Salvia officinalis essential oil to inhibit human HNSCC cell growth. The therapeutic potential of sage essential oil might exceed that of its common use in otorhinolaryngology.
Addresses
  • Hals-, Nasen- und Ohrenklinik, Universität Heidelberg, Deutschland. serkan.sertel@med.uni-heidelberg.de
Autoren
  • S Sertel
  • T Eichhorn
  • PK Plinkert
  • T Efferth
  • T Efferth
DOI
10.1007/s00106-011-2274-3
eISSN
1433-0458
Externe Identifier
  • PubMed Identifier: 21894557
Open access
false
ISSN
0017-6192
Ausgabe der Veröffentlichung
12
Zeitschrift
HNO
Schlüsselwörter
  • Cell Line, Tumor
  • Humans
  • Salvia officinalis
  • Carcinoma, Non-Small-Cell Lung
  • Lung Neoplasms
  • Oils, Volatile
  • Plant Extracts
  • Antineoplastic Agents, Phytogenic
  • Treatment Outcome
  • Apoptosis
  • Cell Survival
  • Dose-Response Relationship, Drug
Sprache
ger
Medium
Print
Paginierung
1203 - 1208
Datum der Veröffentlichung
2011
Status
Published
Datum der Datenerfassung
2011
Titel
[Anticancer activity of Salvia officinalis essential oil against HNSCC cell line (UMSCC1)].
Sub types
  • Journal Article
  • English Abstract
Ausgabe der Zeitschrift
59

Data source: Europe PubMed Central

Abstract
BACKGROUND: Every year there are several hundred thousand new cases of oral cancer worldwide. Clinical oncology is still challenged by toxicity and side effects of multimodal therapy strategies in which is associated with poor prognosis for patients. There is an urgent necessity to develop novel therapy strategies. As the majority of anticancer drugs are of natural origin, natural products represent a valuable source for the identification and development of novel treatment options for cancer. The aim of this investigation was to study the cytotoxicity of Salvia officinalis L. (sage) essential oil. METHODS: Salvia officinalis essential oil was gained by aqueous extraction from plant material and subsequently analyzed by gas chromatography. The cytotoxicity of the essential oil on the squamous human cell carcinoma cell line of the oral cavity (UMSCC1) was assessed with the XTT assay. These experiments revealed the half maximal inhibitory concentration (IC(50)) of the essential oil. It was used in the microarray-based analysis of gene expression of UMSSC1 cells. The results were submitted to a signaling pathway analysis. RESULTS: The main constituents of Salvia officinalis essential oil include the monoterpenes thujone, β-pinene, and 1,8-cineol. Low concentrations of the essential oil increased vitality of the UMSCC1 cells. Beyond the concentration of the IC(50) of 135 µg/ml, sage essential oil reduced UMSSC1 cells viability to a minimum. In the microarray gene expression analysis, genes involved in cancer, cellular growth and proliferation, cell death, cell morphology, cell cycle, gene expression, and DNA repair were the most prominent. The three most significantly regulated pathways by sage were aryl hydrocarbon receptor signaling, cell cycle (G1/S checkpoint) regulation, and p53 signaling. CONCLUSION: To the best of our knowledge, this study suggests for the first time the ability of Salvia officinalis essential oil to inhibit human HNSCC cell growth. The therapeutic potential of sage essential oil might exceed that of its common use in otorhinolaryngology.
Autoren
  • S Sertel
  • T Eichhorn
  • PK Plinkert
  • T Efferth
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/21894557
DOI
10.1007/s00106-011-2274-3
eISSN
1433-0458
Ausgabe der Veröffentlichung
12
Zeitschrift
HNO
Schlüsselwörter
  • Antineoplastic Agents, Phytogenic
  • Apoptosis
  • Carcinoma, Non-Small-Cell Lung
  • Cell Line, Tumor
  • Cell Survival
  • Dose-Response Relationship, Drug
  • Humans
  • Lung Neoplasms
  • Oils, Volatile
  • Plant Extracts
  • Salvia officinalis
  • Treatment Outcome
Sprache
ger
Country
Germany
Paginierung
1203 - 1208
Datum der Veröffentlichung
2011
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2012
Titel
[Anticancer activity of Salvia officinalis essential oil against HNSCC cell line (UMSCC1)].
Sub types
  • English Abstract
  • Journal Article
Ausgabe der Zeitschrift
59

Data source: PubMed

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