Antibacterial Activity and Cytotoxicity of Selected Egyptian Medicinal Plants
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Victor Kuete
- Benjamin Wiench
- Mohamed-Elamir F Hegazy
- Tank A Mohamed
- Aime G Fankam
- Abdelaaty A Shahat
- Thomas Efferth
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000299909300017&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1055/s-0031-1280319
- eISSN
- 1439-0221
- Externe Identifier
- Clarivate Analytics Document Solution ID: 887EI
- PubMed Identifier: 22057918
- ISSN
- 0032-0943
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- PLANTA MEDICA
- Schlüsselwörter
- Egyptian medicinal plants
- Ferulo hermonis
- Apiaceae
- jaeschkeanadiol p-hydroxybenzoate
- antibacterial
- cytotoxicity
- Paginierung
- 193 - 199
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Titel
- Antibacterial Activity and Cytotoxicity of Selected Egyptian Medicinal Plants
- Sub types
- Article
- Ausgabe der Zeitschrift
- 78
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Victor Kuete
- Benjamin Wiench
- Mohamed-Elamir Hegazy
- Tarik Mohamed
- Aimé Fankam
- Abdelaaty Shahat
- Thomas Efferth
- DOI
- 10.1055/s-0031-1280319
- eISSN
- 1439-0221
- ISSN
- 0032-0943
- Ausgabe der Veröffentlichung
- 02
- Zeitschrift
- Planta Medica
- Sprache
- en
- Online publication date
- 2011
- Paginierung
- 193 - 199
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Herausgeber
- Georg Thieme Verlag KG
- Herausgeber URL
- http://dx.doi.org/10.1055/s-0031-1280319
- Datum der Datenerfassung
- 2017
- Titel
- Antibacterial Activity and Cytotoxicity of Selected Egyptian Medicinal Plants
- Ausgabe der Zeitschrift
- 78
Data source: Crossref
- Abstract
- Medicinal plants have been used as a source of remedies since ancient times in Egypt. The present study was designed to investigate the antibacterial activity and the cytotoxicity of the organic extracts from 16 selected medicinal plants of Egypt. The study was also extended to the isolation of the antiproliferative compound jaeschkeanadiol p-hydroxybenzoate (FH-25) from Ferula hermonis. The microbroth dilution was used to determine the minimal inhibitory concentration (MIC) of the samples against twelve bacterial strains belonging to four species, Providencia stuartii, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli, while a resazurin assay was used to assess the cytotoxicity of the extracts on the human pancreatic cancer cell line MiaPaCa-2, breast cancer cell line MCF-7, CCRF-CEM leukemia cells, and their multidrug resistant subline, CEM/ADR5000. The results of the MIC determination indicated that all the studied crude extracts were able to inhibit the growth of at least one of the tested bacterial species, the best activity being recorded with the crude extracts from F. hermonis and Vitis vinifera, whichwere active against 91.7% and 83.3% of the studied bacteria, respectively. The lowest MIC value of 128 μg/mL was recorded against P. stuartii ATCC 29916 and E. coli ATCC 10536 with the extract from V. vinifera and Commiphora molmol, respectively. In the cytotoxicity study, IC50 values below 20 μg/mL were recorded for the crude extract of F. hermonis on all four studied cancer cell lines. FH-25 also showed good cytotoxicity against MCF-7 cells (IC50: 2.47 μg/mL). Finally, the results of the present investigation provided supportive data for the possible use of the plant extracts investigated herein, mostly F. hermonis and V. vinifera in the treatment of bacterial infections and jaeschkeanadiol p-hydroxybenzoate in the control of cancer diseases.
- Addresses
- Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
- Autoren
- Victor Kuete
- Benjamin Wiench
- Mohamed-Elamir F Hegazy
- Tarik A Mohamed
- Aimé G Fankam
- Abdelaaty A Shahat
- Thomas Efferth
- Thomas Efferth
- DOI
- 10.1055/s-0031-1280319
- eISSN
- 1439-0221
- Externe Identifier
- PubMed Identifier: 22057918
- Open access
- false
- ISSN
- 0032-0943
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- Planta medica
- Schlüsselwörter
- Cell Line, Tumor
- Humans
- Pseudomonas
- Escherichia coli
- Klebsiella
- Providencia
- Ferula
- Vitis
- Plants, Medicinal
- Leukemia
- Breast Neoplasms
- Sesquiterpenes
- Plant Extracts
- Antineoplastic Agents, Phytogenic
- Anti-Bacterial Agents
- Phytotherapy
- Microbial Sensitivity Tests
- Inhibitory Concentration 50
- Drug Resistance, Neoplasm
- Egypt
- Female
- Magnoliopsida
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2011
- Paginierung
- 193 - 199
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Datum der Datenerfassung
- 2011
- Titel
- Antibacterial activity and cytotoxicity of selected Egyptian medicinal plants.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 78
Data source: Europe PubMed Central
- Abstract
- Medicinal plants have been used as a source of remedies since ancient times in Egypt. The present study was designed to investigate the antibacterial activity and the cytotoxicity of the organic extracts from 16 selected medicinal plants of Egypt. The study was also extended to the isolation of the antiproliferative compound jaeschkeanadiol p-hydroxybenzoate (FH-25) from Ferula hermonis. The microbroth dilution was used to determine the minimal inhibitory concentration (MIC) of the samples against twelve bacterial strains belonging to four species, Providencia stuartii, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli, while a resazurin assay was used to assess the cytotoxicity of the extracts on the human pancreatic cancer cell line MiaPaCa-2, breast cancer cell line MCF-7, CCRF-CEM leukemia cells, and their multidrug resistant subline, CEM/ADR5000. The results of the MIC determination indicated that all the studied crude extracts were able to inhibit the growth of at least one of the tested bacterial species, the best activity being recorded with the crude extracts from F. hermonis and Vitis vinifera, whichwere active against 91.7% and 83.3% of the studied bacteria, respectively. The lowest MIC value of 128 μg/mL was recorded against P. stuartii ATCC 29916 and E. coli ATCC 10536 with the extract from V. vinifera and Commiphora molmol, respectively. In the cytotoxicity study, IC50 values below 20 μg/mL were recorded for the crude extract of F. hermonis on all four studied cancer cell lines. FH-25 also showed good cytotoxicity against MCF-7 cells (IC50: 2.47 μg/mL). Finally, the results of the present investigation provided supportive data for the possible use of the plant extracts investigated herein, mostly F. hermonis and V. vinifera in the treatment of bacterial infections and jaeschkeanadiol p-hydroxybenzoate in the control of cancer diseases.
- Autoren
- Victor Kuete
- Benjamin Wiench
- Mohamed-Elamir F Hegazy
- Tarik A Mohamed
- Aimé G Fankam
- Abdelaaty A Shahat
- Thomas Efferth
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/22057918
- DOI
- 10.1055/s-0031-1280319
- eISSN
- 1439-0221
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- Planta Med
- Schlüsselwörter
- Anti-Bacterial Agents
- Antineoplastic Agents, Phytogenic
- Breast Neoplasms
- Cell Line, Tumor
- Drug Resistance, Neoplasm
- Egypt
- Escherichia coli
- Female
- Ferula
- Humans
- Inhibitory Concentration 50
- Klebsiella
- Leukemia
- Magnoliopsida
- Microbial Sensitivity Tests
- Phytotherapy
- Plant Extracts
- Plants, Medicinal
- Providencia
- Pseudomonas
- Sesquiterpenes
- Vitis
- Sprache
- eng
- Country
- Germany
- Paginierung
- 193 - 199
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2012
- Titel
- Antibacterial activity and cytotoxicity of selected Egyptian medicinal plants.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 78
Data source: PubMed
- Beziehungen:
- Property of