Review of current and "omics" methods for assessing the toxicity (genotoxicity, teratogenicity and nephrotoxicity) of herbal medicines and mushrooms
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Moustapha Ouedraogo
- Thomas Baudoux
- Caroline Stevigny
- Joelle Nortier
- Jean-Marie Colet
- Thomas Efferth
- Fan Qu
- Jue Zhou
- Kelvin Chan
- Debbie Shaw
- Olavi Pelkonen
- Pierre Duez
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000302844100006&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1016/j.jep.2012.01.059
- eISSN
- 1872-7573
- Externe Identifier
- Clarivate Analytics Document Solution ID: 926PU
- PubMed Identifier: 22386524
- ISSN
- 0378-8741
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- JOURNAL OF ETHNOPHARMACOLOGY
- Schlüsselwörter
- Genotoxicity
- Teratogenicity
- Nephrotoxicity
- Evaluation
- Methods
- Omics
- Paginierung
- 492 - 512
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Titel
- Review of current and "omics" methods for assessing the toxicity (genotoxicity, teratogenicity and nephrotoxicity) of herbal medicines and mushrooms
- Sub types
- Review
- Ausgabe der Zeitschrift
- 140
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Moustapha Ouedraogo
- Thomas Baudoux
- Caroline Stévigny
- Joëlle Nortier
- Jean-Marie Colet
- Thomas Efferth
- Fan Qu
- Jue Zhou
- Kelvin Chan
- Debbie Shaw
- Olavi Pelkonen
- Pierre Duez
- DOI
- 10.1016/j.jep.2012.01.059
- ISSN
- 0378-8741
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- Journal of Ethnopharmacology
- Sprache
- en
- Paginierung
- 492 - 512
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Herausgeber
- Elsevier BV
- Herausgeber URL
- http://dx.doi.org/10.1016/j.jep.2012.01.059
- Datum der Datenerfassung
- 2023
- Titel
- Review of current and “omics” methods for assessing the toxicity (genotoxicity, teratogenicity and nephrotoxicity) of herbal medicines and mushrooms
- Ausgabe der Zeitschrift
- 140
Data source: Crossref
- Abstract
- <h4>Ethnopharmacological relevance</h4>The increasing use of traditional herbal medicines around the world requires more scientific evidence for their putative harmlessness. To this end, a plethora of methods exist, more or less satisfying. In this post-genome era, recent reviews are however scarce, not only on the use of new "omics" methods (transcriptomics, proteomics, metabonomics) for genotoxicity, teratogenicity, and nephrotoxicity assessment, but also on conventional ones.<h4>Methods</h4>The present work aims (i) to review conventional methods used to assess genotoxicity, teratogenicity and nephrotoxicity of medicinal plants and mushrooms; (ii) to report recent progress in the use of "omics" technologies in this field; (iii) to underline advantages and limitations of promising methods; and lastly (iv) to suggest ways whereby the genotoxicity, teratogenicity, and nephrotoxicity assessment of traditional herbal medicines could be more predictive.<h4>Results</h4>Literature and safety reports show that structural alerts, in silico and classical in vitro and in vivo predictive methods are often used. The current trend to develop "omics" technologies to assess genotoxicity, teratogenicity and nephrotoxicity is promising but most often relies on methods that are still not standardized and validated.<h4>Conclusion</h4>Hence, it is critical that toxicologists in industry, regulatory agencies and academic institutions develop a consensus, based on rigorous methods, about the reliability and interpretation of endpoints. It will also be important to regulate the integration of conventional methods for toxicity assessments with new "omics" technologies.
- Addresses
- Laboratory of Pharmacology and Toxicology, Health Sciences Faculty, University of Ouagadougou, 03 BP 7021 Ouagadougou 03, Burkina Faso. mustapha ouedraogo@yahoo.fr
- Autoren
- Moustapha Ouedraogo
- Thomas Baudoux
- Caroline Stévigny
- Joëlle Nortier
- Jean-Marie Colet
- Thomas Efferth
- Thomas Efferth
- Fan Qu
- Jue Zhou
- Kelvin Chan
- Debbie Shaw
- Olavi Pelkonen
- Pierre Duez
- DOI
- 10.1016/j.jep.2012.01.059
- eISSN
- 1872-7573
- Externe Identifier
- PubMed Identifier: 22386524
- Open access
- false
- ISSN
- 0378-8741
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- Journal of ethnopharmacology
- Schlüsselwörter
- Kidney
- Humans
- Agaricales
- Plants, Medicinal
- Mutagens
- Teratogens
- Medicine, Traditional
- Phytotherapy
- Technology, Pharmaceutical
- Proteomics
- Toxicology
- Herbal Medicine
- Transcriptome
- Drug-Related Side Effects and Adverse Reactions
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2012
- Paginierung
- 492 - 512
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Publisher licence
- CC BY-NC-ND
- Datum der Datenerfassung
- 2012
- Titel
- Review of current and "omics" methods for assessing the toxicity (genotoxicity, teratogenicity and nephrotoxicity) of herbal medicines and mushrooms.
- Sub types
- Review
- Journal Article
- Ausgabe der Zeitschrift
- 140
Data source: Europe PubMed Central
- Abstract
- ETHNOPHARMACOLOGICAL RELEVANCE: The increasing use of traditional herbal medicines around the world requires more scientific evidence for their putative harmlessness. To this end, a plethora of methods exist, more or less satisfying. In this post-genome era, recent reviews are however scarce, not only on the use of new "omics" methods (transcriptomics, proteomics, metabonomics) for genotoxicity, teratogenicity, and nephrotoxicity assessment, but also on conventional ones. METHODS: The present work aims (i) to review conventional methods used to assess genotoxicity, teratogenicity and nephrotoxicity of medicinal plants and mushrooms; (ii) to report recent progress in the use of "omics" technologies in this field; (iii) to underline advantages and limitations of promising methods; and lastly (iv) to suggest ways whereby the genotoxicity, teratogenicity, and nephrotoxicity assessment of traditional herbal medicines could be more predictive. RESULTS: Literature and safety reports show that structural alerts, in silico and classical in vitro and in vivo predictive methods are often used. The current trend to develop "omics" technologies to assess genotoxicity, teratogenicity and nephrotoxicity is promising but most often relies on methods that are still not standardized and validated. CONCLUSION: Hence, it is critical that toxicologists in industry, regulatory agencies and academic institutions develop a consensus, based on rigorous methods, about the reliability and interpretation of endpoints. It will also be important to regulate the integration of conventional methods for toxicity assessments with new "omics" technologies.
- Date of acceptance
- 2012
- Autoren
- Moustapha Ouedraogo
- Thomas Baudoux
- Caroline Stévigny
- Joëlle Nortier
- Jean-Marie Colet
- Thomas Efferth
- Fan Qu
- Jue Zhou
- Kelvin Chan
- Debbie Shaw
- Olavi Pelkonen
- Pierre Duez
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/22386524
- DOI
- 10.1016/j.jep.2012.01.059
- eISSN
- 1872-7573
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- J Ethnopharmacol
- Schlüsselwörter
- Agaricales
- Drug-Related Side Effects and Adverse Reactions
- Herbal Medicine
- Humans
- Kidney
- Medicine, Traditional
- Mutagens
- Phytotherapy
- Plants, Medicinal
- Proteomics
- Technology, Pharmaceutical
- Teratogens
- Toxicology
- Transcriptome
- Sprache
- eng
- Country
- Ireland
- Paginierung
- 492 - 512
- PII
- S0378-8741(12)00114-6
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2012
- Titel
- Review of current and "omics" methods for assessing the toxicity (genotoxicity, teratogenicity and nephrotoxicity) of herbal medicines and mushrooms.
- Sub types
- Journal Article
- Review
- Ausgabe der Zeitschrift
- 140
Data source: PubMed
- Beziehungen:
- Property of