Antibacterial Activity and Anticancer Activity of Rosmarinus officinalis L. Essential Oil Compared to That of Its Main Components

Publication type:
Journal article
Metadata:
Autoren
  • Wei Wang
  • Nan Li
  • Meng Luo
  • Yuangang Zu
  • Thomas Efferth
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000302120600031&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.3390/molecules17032704
Externe Identifier
  • Clarivate Analytics Document Solution ID: 916RJ
  • PubMed Identifier: 22391603
ISSN
1420-3049
Ausgabe der Veröffentlichung
3
Zeitschrift
MOLECULES
Schlüsselwörter
  • Rosmarinus officinalis L.
  • 1,8-cineole
  • alpha-pinene
  • beta-pinene
  • antibacterial activities
  • cytotoxicity
Paginierung
2704 - 2713
Datum der Veröffentlichung
2012
Status
Published
Titel
Antibacterial Activity and Anticancer Activity of <i>Rosmarinus officinalis</i> L. Essential Oil Compared to That of Its Main Components
Sub types
  • Article
Ausgabe der Zeitschrift
17

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Wei Wang
  • Nan Li
  • Meng Luo
  • Yuangang Zu
  • Thomas Efferth
DOI
10.3390/molecules17032704
eISSN
1420-3049
Ausgabe der Veröffentlichung
3
Zeitschrift
Molecules
Sprache
en
Online publication date
2012
Paginierung
2704 - 2713
Status
Published online
Herausgeber
MDPI AG
Herausgeber URL
http://dx.doi.org/10.3390/molecules17032704
Datum der Datenerfassung
2018
Titel
Antibacterial Activity and Anticancer Activity of Rosmarinus officinalis L. Essential Oil Compared to That of Its Main Components
Ausgabe der Zeitschrift
17

Data source: Crossref

Abstract
In this study, Rosmarinus officinalis L. essential oil and three of its main components 1,8-cineole (27.23%), α-pinene (19.43%) and β-pinene (6.71%) were evaluated for their in vitro antibacterial activities and toxicology properties. R. officinalis L. essential oil possessed similar antibacterial activities to α-pinene, and a little bit better than β-pinene, while 1,8-cineole possessed the lowest antibacterial activities. R. officinalis L. essential oil exhibited the strongest cytotoxicity towards three human cancer cells. Its inhibition concentration 50% (IC₅₀) values on SK-OV-3, HO-8910 and Bel-7402 were 0.025‰, 0.076‰ and 0.13‰ (v/v), respectively. The cytotoxicity of all the test samples on SK-OV-3 was significantly stronger than on HO-8910 and Bel-7402. In general, R. officinalis L. essential oil showed greater activity than its components in both antibacterial and anticancer test systems, and the activities were mostly related to their concentrations.
Addresses
  • Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Hexing Road 26, Harbin 150040, China.
Autoren
DOI
10.3390/molecules17032704
eISSN
1420-3049
Externe Identifier
  • PubMed Identifier: 22391603
  • PubMed Central ID: PMC6268287
Open access
true
ISSN
1420-3049
Ausgabe der Veröffentlichung
3
Zeitschrift
Molecules (Basel, Switzerland)
Schlüsselwörter
  • Cell Line, Tumor
  • Humans
  • Bacteria
  • Rosmarinus
  • Cyclohexanols
  • Monoterpenes
  • Oils, Volatile
  • Plant Extracts
  • Antineoplastic Agents, Phytogenic
  • Anti-Bacterial Agents
  • Drug Screening Assays, Antitumor
  • Microbial Sensitivity Tests
  • Inhibitory Concentration 50
  • Cell Survival
  • Bridged Bicyclo Compounds
  • Eucalyptol
  • Bicyclic Monoterpenes
Sprache
eng
Medium
Electronic
Online publication date
2012
Open access status
Open Access
Paginierung
2704 - 2713
Datum der Veröffentlichung
2012
Status
Published
Publisher licence
CC BY
Datum der Datenerfassung
2012
Titel
Antibacterial activity and anticancer activity of Rosmarinus officinalis L. essential oil compared to that of its main components.
Sub types
  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • research-article
  • Journal Article
Ausgabe der Zeitschrift
17

Files

https://www.mdpi.com/1420-3049/17/3/2704/pdf?version=1403113493 https://europepmc.org/articles/PMC6268287?pdf=render

Data source: Europe PubMed Central

Abstract
In this study, Rosmarinus officinalis L. essential oil and three of its main components 1,8-cineole (27.23%), α-pinene (19.43%) and β-pinene (6.71%) were evaluated for their in vitro antibacterial activities and toxicology properties. R. officinalis L. essential oil possessed similar antibacterial activities to α-pinene, and a little bit better than β-pinene, while 1,8-cineole possessed the lowest antibacterial activities. R. officinalis L. essential oil exhibited the strongest cytotoxicity towards three human cancer cells. Its inhibition concentration 50% (IC₅₀) values on SK-OV-3, HO-8910 and Bel-7402 were 0.025‰, 0.076‰ and 0.13‰ (v/v), respectively. The cytotoxicity of all the test samples on SK-OV-3 was significantly stronger than on HO-8910 and Bel-7402. In general, R. officinalis L. essential oil showed greater activity than its components in both antibacterial and anticancer test systems, and the activities were mostly related to their concentrations.
Date of acceptance
2012
Autoren
  • Wei Wang
  • Nan Li
  • Meng Luo
  • Yuangang Zu
  • Thomas Efferth
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/22391603
DOI
10.3390/molecules17032704
eISSN
1420-3049
Externe Identifier
  • PubMed Central ID: PMC6268287
Ausgabe der Veröffentlichung
3
Zeitschrift
Molecules
Schlüsselwörter
  • Anti-Bacterial Agents
  • Antineoplastic Agents, Phytogenic
  • Bacteria
  • Bicyclic Monoterpenes
  • Bridged Bicyclo Compounds
  • Cell Line, Tumor
  • Cell Survival
  • Cyclohexanols
  • Drug Screening Assays, Antitumor
  • Eucalyptol
  • Humans
  • Inhibitory Concentration 50
  • Microbial Sensitivity Tests
  • Monoterpenes
  • Oils, Volatile
  • Plant Extracts
  • Rosmarinus
Sprache
eng
Country
Switzerland
Paginierung
2704 - 2713
PII
molecules17032704
Datum der Veröffentlichung
2012
Status
Published online
Datum, an dem der Datensatz öffentlich gemacht wurde
2012
Titel
Antibacterial activity and anticancer activity of Rosmarinus officinalis L. essential oil compared to that of its main components.
Sub types
  • Comparative Study
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
17

Data source: PubMed

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