Factors Determining Sensitivity and Resistance of Tumor Cells to Arsenic Trioxide
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Serkan Sertel
- Margaret Tome
- Margaret M Briehl
- Judith Bauer
- Kai Hock
- Peter K Plinkert
- Thomas Efferth
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000305336400003&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1371/journal.pone.0035584
- Externe Identifier
- Clarivate Analytics Document Solution ID: 959TN
- PubMed Identifier: 22590507
- ISSN
- 1932-6203
- Ausgabe der Veröffentlichung
- 5
- Zeitschrift
- PLOS ONE
- Artikelnummer
- ARTN e35584
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Titel
- Factors Determining Sensitivity and Resistance of Tumor Cells to Arsenic Trioxide
- Sub types
- Article
- Ausgabe der Zeitschrift
- 7
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Serkan Sertel
- Margaret Tome
- Margaret M Briehl
- Judith Bauer
- Kai Hock
- Peter K Plinkert
- Thomas Efferth
- DOI
- 10.1371/journal.pone.0035584
- Editoren
- Alexander James Roy Bishop
- eISSN
- 1932-6203
- Ausgabe der Veröffentlichung
- 5
- Zeitschrift
- PLoS ONE
- Sprache
- en
- Online publication date
- 2012
- Paginierung
- e35584 - e35584
- Status
- Published online
- Herausgeber
- Public Library of Science (PLoS)
- Herausgeber URL
- http://dx.doi.org/10.1371/journal.pone.0035584
- Datum der Datenerfassung
- 2024
- Titel
- Factors Determining Sensitivity and Resistance of Tumor Cells to Arsenic Trioxide
- Ausgabe der Zeitschrift
- 7
Data source: Crossref
- Abstract
- Previously, arsenic trioxide showed impressive regression rates of acute promyelocytic leukemia. Here, we investigated molecular determinants of sensitivity and resistance of cell lines of different tumor types towards arsenic trioxide. Arsenic trioxide was the most cytotoxic compound among 8 arsenicals investigated in the NCI cell line panel. We correlated transcriptome-wide microarray-based mRNA expression to the IC(50) values for arsenic trioxide by bioinformatic approaches (COMPARE and hierarchical cluster analyses, Ingenuity signaling pathway analysis). Among the identified pathways were signaling routes for p53, integrin-linked kinase, and actin cytoskeleton. Genes from these pathways significantly predicted cellular response to arsenic trioxide. Then, we analyzed whether classical drug resistance factors may also play a role for arsenic trioxide. Cell lines transfected with cDNAs for catalase, thioredoxin, or the anti-apoptotic bcl-2 gene were more resistant to arsenic trioxide than mock vector transfected cells. Multidrug-resistant cells overexpressing the MDR1, MRP1 or BCRP genes were not cross-resistant to arsenic trioxide. Our approach revealed that response of tumor cells towards arsenic trioxide is multi-factorial.
- Addresses
- Department of Otorhinolaryngology, Head and Neck Surgery, University of Heidelberg, Heidelberg, Germany.
- Autoren
- Serkan Sertel
- Margaret Tome
- Margaret M Briehl
- Judith Bauer
- Kai Hock
- Peter K Plinkert
- Thomas Efferth
- Thomas Efferth
- DOI
- 10.1371/journal.pone.0035584
- eISSN
- 1932-6203
- Externe Identifier
- PubMed Identifier: 22590507
- PubMed Central ID: PMC3349672
- Open access
- true
- ISSN
- 1932-6203
- Ausgabe der Veröffentlichung
- 5
- Zeitschrift
- PloS one
- Schlüsselwörter
- Cell Line, Tumor
- Humans
- Arsenicals
- Oxides
- Neoplasm Proteins
- RNA, Messenger
- RNA, Neoplasm
- Antineoplastic Agents
- Cytotoxins
- Oligonucleotide Array Sequence Analysis
- Signal Transduction
- Gene Expression Regulation, Neoplastic
- Drug Resistance, Neoplasm
- Actin Cytoskeleton
- Arsenic Trioxide
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2012
- Open access status
- Open Access
- Paginierung
- e35584
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2012
- Titel
- Factors determining sensitivity and resistance of tumor cells to arsenic trioxide.
- Sub types
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 7
Files
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0035584&type=printable https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22590507/pdf/?tool=EBI https://europepmc.org/articles/PMC3349672?pdf=render
Data source: Europe PubMed Central
- Abstract
- Previously, arsenic trioxide showed impressive regression rates of acute promyelocytic leukemia. Here, we investigated molecular determinants of sensitivity and resistance of cell lines of different tumor types towards arsenic trioxide. Arsenic trioxide was the most cytotoxic compound among 8 arsenicals investigated in the NCI cell line panel. We correlated transcriptome-wide microarray-based mRNA expression to the IC(50) values for arsenic trioxide by bioinformatic approaches (COMPARE and hierarchical cluster analyses, Ingenuity signaling pathway analysis). Among the identified pathways were signaling routes for p53, integrin-linked kinase, and actin cytoskeleton. Genes from these pathways significantly predicted cellular response to arsenic trioxide. Then, we analyzed whether classical drug resistance factors may also play a role for arsenic trioxide. Cell lines transfected with cDNAs for catalase, thioredoxin, or the anti-apoptotic bcl-2 gene were more resistant to arsenic trioxide than mock vector transfected cells. Multidrug-resistant cells overexpressing the MDR1, MRP1 or BCRP genes were not cross-resistant to arsenic trioxide. Our approach revealed that response of tumor cells towards arsenic trioxide is multi-factorial.
- Date of acceptance
- 2012
- Autoren
- Serkan Sertel
- Margaret Tome
- Margaret M Briehl
- Judith Bauer
- Kai Hock
- Peter K Plinkert
- Thomas Efferth
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/22590507
- DOI
- 10.1371/journal.pone.0035584
- eISSN
- 1932-6203
- Externe Identifier
- PubMed Central ID: PMC3349672
- Ausgabe der Veröffentlichung
- 5
- Zeitschrift
- PLoS One
- Schlüsselwörter
- Actin Cytoskeleton
- Antineoplastic Agents
- Arsenic Trioxide
- Arsenicals
- Cell Line, Tumor
- Cytotoxins
- Drug Resistance, Neoplasm
- Gene Expression Regulation, Neoplastic
- Humans
- Neoplasm Proteins
- Oligonucleotide Array Sequence Analysis
- Oxides
- RNA, Messenger
- RNA, Neoplasm
- Signal Transduction
- Sprache
- eng
- Country
- United States
- Paginierung
- e35584
- PII
- PONE-D-12-01322
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2012
- Titel
- Factors determining sensitivity and resistance of tumor cells to arsenic trioxide.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 7
Data source: PubMed
- Beziehungen:
- Property of