New artesunic acid homodimers: Potent reversal agents of multidrug resistance in leukemia cells
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Christoph Reiter
- Astrid Herrmann
- Aysun Capci
- Thomas Efferth
- Svetlana B Tsogoeva
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000308808700034&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1016/j.bmc.2012.07.015
- Externe Identifier
- Clarivate Analytics Document Solution ID: 006GY
- PubMed Identifier: 22884578
- ISSN
- 0968-0896
- Ausgabe der Veröffentlichung
- 18
- Zeitschrift
- BIOORGANIC & MEDICINAL CHEMISTRY
- Schlüsselwörter
- Artesunic acid
- Homodimers
- Linker
- Drug design
- Chemotherapy
- Apoptosis
- Multidrug resistance
- Reactive oxygen species
- Paginierung
- 5637 - 5641
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Titel
- New artesunic acid homodimers: Potent reversal agents of multidrug resistance in leukemia cells
- Sub types
- Article
- Ausgabe der Zeitschrift
- 20
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Christoph Reiter
- Astrid Herrmann
- Aysun Çapci
- Thomas Efferth
- Svetlana B Tsogoeva
- DOI
- 10.1016/j.bmc.2012.07.015
- ISSN
- 0968-0896
- Ausgabe der Veröffentlichung
- 18
- Zeitschrift
- Bioorganic & Medicinal Chemistry
- Sprache
- en
- Paginierung
- 5637 - 5641
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Herausgeber
- Elsevier BV
- Herausgeber URL
- http://dx.doi.org/10.1016/j.bmc.2012.07.015
- Datum der Datenerfassung
- 2018
- Titel
- New artesunic acid homodimers: Potent reversal agents of multidrug resistance in leukemia cells
- Ausgabe der Zeitschrift
- 20
Data source: Crossref
- Abstract
- To evade the problem of multidrug resistance, hybridization of natural products in dimers is considered as an effective method. After the successful synthesis of three artesunic acid homodimers connected by different types of chemical linkers, we analyzed their activity against human CCRF-CEM and multidrug-resistant P-glycoprotein-overexpressing CEM/ADR 5000 leukemia cells and observed, that multidrug resistant cells were not cross-resistant to the new compounds. Collateral sensitivity was observed for artesunic acid homodimer 2. The obtained results deliver valuable information about the linker's structure which is required for homodimers to be highly cytotoxic.
- Addresses
- Institute of Organic Chemistry I, University of Erlangen-Nuremberg, Henkestrasse 42, 91054 Erlangen, Germany.
- Autoren
- Christoph Reiter
- Astrid Herrmann
- Aysun Çapci
- Thomas Efferth
- Thomas Efferth
- Svetlana B Tsogoeva
- DOI
- 10.1016/j.bmc.2012.07.015
- eISSN
- 1464-3391
- Externe Identifier
- PubMed Identifier: 22884578
- Open access
- false
- ISSN
- 0968-0896
- Ausgabe der Veröffentlichung
- 18
- Zeitschrift
- Bioorganic & medicinal chemistry
- Schlüsselwörter
- Tumor Cells, Cultured
- Humans
- Leukemia
- Succinates
- Artemisinins
- Antineoplastic Agents
- Drug Screening Assays, Antitumor
- Drug Resistance, Multiple
- Cell Survival
- Molecular Structure
- Structure-Activity Relationship
- Dimerization
- Dose-Response Relationship, Drug
- Drug Resistance, Neoplasm
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2012
- Paginierung
- 5637 - 5641
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Datum der Datenerfassung
- 2012
- Titel
- New artesunic acid homodimers: potent reversal agents of multidrug resistance in leukemia cells.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 20
Data source: Europe PubMed Central
- Abstract
- To evade the problem of multidrug resistance, hybridization of natural products in dimers is considered as an effective method. After the successful synthesis of three artesunic acid homodimers connected by different types of chemical linkers, we analyzed their activity against human CCRF-CEM and multidrug-resistant P-glycoprotein-overexpressing CEM/ADR 5000 leukemia cells and observed, that multidrug resistant cells were not cross-resistant to the new compounds. Collateral sensitivity was observed for artesunic acid homodimer 2. The obtained results deliver valuable information about the linker's structure which is required for homodimers to be highly cytotoxic.
- Date of acceptance
- 2012
- Autoren
- Christoph Reiter
- Astrid Herrmann
- Aysun Çapci
- Thomas Efferth
- Svetlana B Tsogoeva
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/22884578
- DOI
- 10.1016/j.bmc.2012.07.015
- eISSN
- 1464-3391
- Ausgabe der Veröffentlichung
- 18
- Zeitschrift
- Bioorg Med Chem
- Schlüsselwörter
- Antineoplastic Agents
- Artemisinins
- Cell Survival
- Dimerization
- Dose-Response Relationship, Drug
- Drug Resistance, Multiple
- Drug Resistance, Neoplasm
- Drug Screening Assays, Antitumor
- Humans
- Leukemia
- Molecular Structure
- Structure-Activity Relationship
- Succinates
- Tumor Cells, Cultured
- Sprache
- eng
- Country
- England
- Paginierung
- 5637 - 5641
- PII
- S0968-0896(12)00567-6
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2013
- Titel
- New artesunic acid homodimers: potent reversal agents of multidrug resistance in leukemia cells.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 20
Data source: PubMed
- Beziehungen:
- Property of