Phytochemical Analysis and Cytotoxicity Towards Multidrug-Resistant Leukemia Cells of Essential Oils Derived from Lebanese Medicinal Plants

Publication type:
Journal article
Metadata:
Autoren
  • Antoine M Saab
  • Alessandra Guerrini
  • Gianni Sacchetti
  • Silvia Maietti
  • Ma'en Zeino
  • Joachim Arend
  • Roberto Gambari
  • Francesco Bernardi
  • Thomas Efferth
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000312554100006&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1055/s-0032-1327896
Externe Identifier
  • Clarivate Analytics Document Solution ID: 057HP
  • PubMed Identifier: 23154840
ISSN
0032-0943
Ausgabe der Veröffentlichung
18
Zeitschrift
PLANTA MEDICA
Schlüsselwörter
  • cancer
  • essential oils
  • gas chromatography
  • multidrug resistance
  • Juniperus excelsa
  • Juniperus oxycedrus
  • Cupressaceae
  • Cedrus libani
  • Pinus pinea
  • Pinaceae
Paginierung
1927 - 1931
Datum der Veröffentlichung
2012
Status
Published
Titel
Phytochemical Analysis and Cytotoxicity Towards Multidrug-Resistant Leukemia Cells of Essential Oils Derived from Lebanese Medicinal Plants
Sub types
  • Article
Ausgabe der Zeitschrift
78

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Antoine Saab
  • Alessandra Guerrini
  • Gianni Sacchetti
  • Silvia Maietti
  • Maʼen Zeino
  • Joachim Arend
  • Roberto Gambari
  • Francesco Bernardi
  • Thomas Efferth
DOI
10.1055/s-0032-1327896
eISSN
1439-0221
ISSN
0032-0943
Ausgabe der Veröffentlichung
18
Zeitschrift
Planta Medica
Sprache
en
Online publication date
2012
Paginierung
1927 - 1931
Status
Published online
Herausgeber
Georg Thieme Verlag KG
Herausgeber URL
http://dx.doi.org/10.1055/s-0032-1327896
Datum der Datenerfassung
2017
Titel
Phytochemical Analysis and Cytotoxicity Towards Multidrug-Resistant Leukemia Cells of Essential Oils Derived from Lebanese Medicinal Plants
Ausgabe der Zeitschrift
78

Data source: Crossref

Abstract
Juniperus excelsa fruit essential oil as well as J. oxycedrus, Cedrus libani, and Pinus pinea wood essential oils have been obtained with yields between 2.2 ± 0.3 % to 3.4 ± 0.5 % and analyzed by gas chromatography. Sesquiterpenes mainly characterized C. libani and J. oxycedrus essential oils, while in P. pinea and J. excelsa, monoterpenes were the most abundant compounds. In J. oxycedrus, cis-calamenene (7.8 %), cuparene (3.8 %), and cis-thujopsenal (2.0 %) have been detected for the first time. The cytotoxic activity of these essential oils against drug-sensitive CCRF-CEM and multidrug-resistant P-glycoprotein-expressing CEM/ADR5000 leukemia cells has been investigated (IC₅₀ values: 29.46 to 61.54 µg/mL). Remarkably, multidrug-resistant CEM/ADR5000 cells did not reveal cross-resistance, indicating that these essential oils might be useful to treat otherwise drug-resistant and refractory tumors.
Addresses
  • Faculty of Sciences II, Lebanese University, Chemistry Department, Fanar, Beirut, Lebanon.
Autoren
  • Antoine M Saab
  • Alessandra Guerrini
  • Gianni Sacchetti
  • Silvia Maietti
  • Maʼen Zeino
  • Joachim Arend
  • Roberto Gambari
  • Francesco Bernardi
  • Thomas Efferth
  • Thomas Efferth
DOI
10.1055/s-0032-1327896
eISSN
1439-0221
Externe Identifier
  • PubMed Identifier: 23154840
Open access
false
ISSN
0032-0943
Ausgabe der Veröffentlichung
18
Zeitschrift
Planta medica
Schlüsselwörter
  • Tumor Cells, Cultured
  • Humans
  • Juniperus
  • Cedrus
  • Pinus
  • Fruit
  • Plants, Medicinal
  • Leukemia
  • Monoterpenes
  • Sesquiterpenes
  • Oils, Volatile
  • Antineoplastic Agents, Phytogenic
  • Phytotherapy
  • Drug Resistance, Multiple
  • Drug Resistance, Neoplasm
  • Wood
  • Lebanon
Sprache
eng
Medium
Print-Electronic
Online publication date
2012
Paginierung
1927 - 1931
Datum der Veröffentlichung
2012
Status
Published
Datum der Datenerfassung
2012
Titel
Phytochemical analysis and cytotoxicity towards multidrug-resistant leukemia cells of essential oils derived from Lebanese medicinal plants.
Sub types
  • Letter
Ausgabe der Zeitschrift
78

Data source: Europe PubMed Central

Abstract
Juniperus excelsa fruit essential oil as well as J. oxycedrus, Cedrus libani, and Pinus pinea wood essential oils have been obtained with yields between 2.2 ± 0.3 % to 3.4 ± 0.5 % and analyzed by gas chromatography. Sesquiterpenes mainly characterized C. libani and J. oxycedrus essential oils, while in P. pinea and J. excelsa, monoterpenes were the most abundant compounds. In J. oxycedrus, cis-calamenene (7.8 %), cuparene (3.8 %), and cis-thujopsenal (2.0 %) have been detected for the first time. The cytotoxic activity of these essential oils against drug-sensitive CCRF-CEM and multidrug-resistant P-glycoprotein-expressing CEM/ADR5000 leukemia cells has been investigated (IC₅₀ values: 29.46 to 61.54 µg/mL). Remarkably, multidrug-resistant CEM/ADR5000 cells did not reveal cross-resistance, indicating that these essential oils might be useful to treat otherwise drug-resistant and refractory tumors.
Autoren
  • Antoine M Saab
  • Alessandra Guerrini
  • Gianni Sacchetti
  • Silvia Maietti
  • Maʼen Zeino
  • Joachim Arend
  • Roberto Gambari
  • Francesco Bernardi
  • Thomas Efferth
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/23154840
DOI
10.1055/s-0032-1327896
eISSN
1439-0221
Ausgabe der Veröffentlichung
18
Zeitschrift
Planta Med
Schlüsselwörter
  • Antineoplastic Agents, Phytogenic
  • Cedrus
  • Drug Resistance, Multiple
  • Drug Resistance, Neoplasm
  • Fruit
  • Humans
  • Juniperus
  • Lebanon
  • Leukemia
  • Monoterpenes
  • Oils, Volatile
  • Phytotherapy
  • Pinus
  • Plants, Medicinal
  • Sesquiterpenes
  • Tumor Cells, Cultured
  • Wood
Sprache
eng
Country
Germany
Paginierung
1927 - 1931
Datum der Veröffentlichung
2012
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2013
Titel
Phytochemical analysis and cytotoxicity towards multidrug-resistant leukemia cells of essential oils derived from Lebanese medicinal plants.
Sub types
  • Letter
Ausgabe der Zeitschrift
78

Data source: PubMed

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