Molecular interaction of artemisinin with translationally controlled tumor protein (TCTP) of Plasmodium falciparum

Publication type:
Journal article
Metadata:
Autoren
  • Tolga Eichhorn
  • Dominic Winter
  • Berthold Buechele
  • Natalie Dirdjaja
  • Martin Frank
  • Wolf-Dieter Lehmann
  • Rolf Mertens
  • R Luise Krauth-Siegel
  • Thomas Simmet
  • Joachim Granzin
  • Thomas Efferth
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000313611200005&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.bcp.2012.10.006
eISSN
1873-2968
Externe Identifier
  • Clarivate Analytics Document Solution ID: 071RF
  • PubMed Identifier: 23085438
ISSN
0006-2952
Ausgabe der Veröffentlichung
1
Zeitschrift
BIOCHEMICAL PHARMACOLOGY
Schlüsselwörter
  • Artemisinin
  • Translationally controlled tumor protein
  • Plasmodium falciparum
Paginierung
38 - 45
Datum der Veröffentlichung
2013
Status
Published
Titel
Molecular interaction of artemisinin with translationally controlled tumor protein (TCTP) of <i>Plasmodium falciparum</i>
Sub types
  • Article
Ausgabe der Zeitschrift
85

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Tolga Eichhorn
  • Dominic Winter
  • Berthold Büchele
  • Natalie Dirdjaja
  • Martin Frank
  • Wolf-Dieter Lehmann
  • Rolf Mertens
  • R Luise Krauth-Siegel
  • Thomas Simmet
  • Joachim Granzin
  • Thomas Efferth
DOI
10.1016/j.bcp.2012.10.006
ISSN
0006-2952
Ausgabe der Veröffentlichung
1
Zeitschrift
Biochemical Pharmacology
Sprache
en
Paginierung
38 - 45
Datum der Veröffentlichung
2013
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.bcp.2012.10.006
Datum der Datenerfassung
2021
Titel
Molecular interaction of artemisinin with translationally controlled tumor protein (TCTP) of Plasmodium falciparum
Ausgabe der Zeitschrift
85

Data source: Crossref

Abstract
Malaria causes millions of death cases per year. Since Plasmodium falciparum rapidly develops drug resistance, it is of high importance to investigate potential drug targets which may lead to novel rational therapy approaches. Here we report on the interaction of translationally controlled tumor protein of P. falciparum (PfTCTP) with the anti-malarial drug artemisinin. Furthermore, we investigated the crystal structure of PfTCTP. Using mass spectrometry, bioinformatic approaches and surface plasmon resonance spectroscopy, we identified novel binding sites of artemisinin which are in direct neighborhood to amino acids 19-46, 108-134 and 140-163. The regions covered by these residues are known to be functionally important for TCTP function. We conclude that interaction of artemisinin with TCTP may be at least in part explain the antimalarial activity of artemisinin.
Addresses
  • Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany.
Autoren
  • Tolga Eichhorn
  • Dominic Winter
  • Berthold Büchele
  • Natalie Dirdjaja
  • Martin Frank
  • Wolf-Dieter Lehmann
  • Rolf Mertens
  • R Luise Krauth-Siegel
  • Thomas Simmet
  • Joachim Granzin
  • Thomas Efferth
  • Thomas Efferth
DOI
10.1016/j.bcp.2012.10.006
eISSN
1873-2968
Externe Identifier
  • PubMed Identifier: 23085438
Funding acknowledgements
  • Mathworks, Natick, MA, USA:
Open access
false
ISSN
0006-2952
Ausgabe der Veröffentlichung
1
Zeitschrift
Biochemical pharmacology
Schlüsselwörter
  • Humans
  • Plasmodium falciparum
  • Artemisinins
  • Protozoan Proteins
  • Recombinant Proteins
  • Antimalarials
  • Crystallography, X-Ray
  • Surface Plasmon Resonance
  • Binding Sites
  • Molecular Structure
  • Protein Binding
  • Computer Simulation
  • Molecular Docking Simulation
  • Biomarkers, Tumor
  • Tumor Protein, Translationally-Controlled 1
Sprache
eng
Medium
Print-Electronic
Online publication date
2012
Paginierung
38 - 45
Datum der Veröffentlichung
2013
Status
Published
Datum der Datenerfassung
2012
Titel
Molecular interaction of artemisinin with translationally controlled tumor protein (TCTP) of Plasmodium falciparum.
Sub types
  • Research Support, Non-U.S. Gov't
  • Journal Article
Ausgabe der Zeitschrift
85

Data source: Europe PubMed Central

Abstract
Malaria causes millions of death cases per year. Since Plasmodium falciparum rapidly develops drug resistance, it is of high importance to investigate potential drug targets which may lead to novel rational therapy approaches. Here we report on the interaction of translationally controlled tumor protein of P. falciparum (PfTCTP) with the anti-malarial drug artemisinin. Furthermore, we investigated the crystal structure of PfTCTP. Using mass spectrometry, bioinformatic approaches and surface plasmon resonance spectroscopy, we identified novel binding sites of artemisinin which are in direct neighborhood to amino acids 19-46, 108-134 and 140-163. The regions covered by these residues are known to be functionally important for TCTP function. We conclude that interaction of artemisinin with TCTP may be at least in part explain the antimalarial activity of artemisinin.
Date of acceptance
2012
Autoren
  • Tolga Eichhorn
  • Dominic Winter
  • Berthold Büchele
  • Natalie Dirdjaja
  • Martin Frank
  • Wolf-Dieter Lehmann
  • Rolf Mertens
  • R Luise Krauth-Siegel
  • Thomas Simmet
  • Joachim Granzin
  • Thomas Efferth
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/23085438
DOI
10.1016/j.bcp.2012.10.006
eISSN
1873-2968
Ausgabe der Veröffentlichung
1
Zeitschrift
Biochem Pharmacol
Schlüsselwörter
  • Antimalarials
  • Artemisinins
  • Binding Sites
  • Biomarkers, Tumor
  • Computer Simulation
  • Crystallography, X-Ray
  • Humans
  • Molecular Docking Simulation
  • Molecular Structure
  • Plasmodium falciparum
  • Protein Binding
  • Protozoan Proteins
  • Recombinant Proteins
  • Surface Plasmon Resonance
  • Tumor Protein, Translationally-Controlled 1
Sprache
eng
Country
England
Paginierung
38 - 45
PII
S0006-2952(12)00678-8
Datum der Veröffentlichung
2013
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2013
Titel
Molecular interaction of artemisinin with translationally controlled tumor protein (TCTP) of Plasmodium falciparum.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
85

Data source: PubMed

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