Alkamides from Echinacea angustifolia Interact with P-Glycoprotein of Primary Brain Capillary Endothelial Cells Isolated from Porcine Brain Blood Vessels
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Anne Mahringer
- Karin Ardjomand-Woelkart
- Rudolf Bauer
- Gert Fricker
- Thomas Efferth
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000315948000004&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1055/s-0032-1328090
- eISSN
- 1439-0221
- Externe Identifier
- Clarivate Analytics Document Solution ID: 103VQ
- PubMed Identifier: 23322561
- ISSN
- 0032-0943
- Ausgabe der Veröffentlichung
- 3-4
- Zeitschrift
- PLANTA MEDICA
- Schlüsselwörter
- ABC transporter
- alkamides
- blood-brain barrier
- Echinacea angustifolia
- Asteraceae
- P-glycoprotein
- inhibitor
- Paginierung
- 214 - 218
- Datum der Veröffentlichung
- 2013
- Status
- Published
- Titel
- Alkamides from <i>Echinacea angustifolia</i> Interact with P-Glycoprotein of Primary Brain Capillary Endothelial Cells Isolated from Porcine Brain Blood Vessels
- Sub types
- Article
- Ausgabe der Zeitschrift
- 79
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Anne Mahringer
- Karin Ardjomand-Woelkart
- Rudolf Bauer
- Gert Fricker
- Thomas Efferth
- DOI
- 10.1055/s-0032-1328090
- eISSN
- 1439-0221
- ISSN
- 0032-0943
- Ausgabe der Veröffentlichung
- 03/04
- Zeitschrift
- Planta Medica
- Sprache
- en
- Online publication date
- 2013
- Paginierung
- 214 - 218
- Status
- Published online
- Herausgeber
- Georg Thieme Verlag KG
- Herausgeber URL
- http://dx.doi.org/10.1055/s-0032-1328090
- Datum der Datenerfassung
- 2017
- Titel
- Alkamides from Echinacea angustifolia Interact with P-Glycoprotein of Primary Brain Capillary Endothelial Cells Isolated from Porcine Brain Blood Vessels
- Ausgabe der Zeitschrift
- 79
Data source: Crossref
- Abstract
- The blood-brain barrier prevents the passage of toxic compounds from blood circulation into brain tissue. Unfortunately, drugs for the treatment of neurodegenerative diseases, brain tumors, and other diseases also do not cross the blood-brain barrier. In the present investigation, we used isolated porcine brain capillary endothelial cells and a flow cytometric calcein-AM assay to analyze inhibition of P-glycoprotein, a major constituent of the blood-brain barrier. We tested 8 alkamides isolated from Echinacea angustifolia and found that four of them inhibited P-glycoprotein-mediated calcein transport in porcine brain capillary endothelial cells.
- Addresses
- Institute of Pharmacy and Molecular Biotechnology, Department of Pharmaceutical Technology and Pharmacology, University of Heidelberg, Heidelberg, Germany.
- Autoren
- Anne Mahringer
- Karin Ardjomand-Woelkart
- Rudolf Bauer
- Gert Fricker
- Thomas Efferth
- Thomas Efferth
- DOI
- 10.1055/s-0032-1328090
- eISSN
- 1439-0221
- Externe Identifier
- PubMed Identifier: 23322561
- Open access
- false
- ISSN
- 0032-0943
- Ausgabe der Veröffentlichung
- 3-4
- Zeitschrift
- Planta medica
- Schlüsselwörter
- Blood-Brain Barrier
- Brain
- Cells, Cultured
- Endothelial Cells
- Animals
- Swine
- Echinacea
- Fluoresceins
- Flow Cytometry
- Molecular Structure
- Biological Transport
- Dose-Response Relationship, Drug
- Polyunsaturated Alkamides
- ATP Binding Cassette Transporter, Subfamily B
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2013
- Paginierung
- 214 - 218
- Datum der Veröffentlichung
- 2013
- Status
- Published
- Datum der Datenerfassung
- 2013
- Titel
- Alkamides from Echinacea angustifolia Interact with P-glycoprotein of primary brain capillary endothelial cells isolated from porcine brain blood vessels.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 79
Data source: Europe PubMed Central
- Abstract
- The blood-brain barrier prevents the passage of toxic compounds from blood circulation into brain tissue. Unfortunately, drugs for the treatment of neurodegenerative diseases, brain tumors, and other diseases also do not cross the blood-brain barrier. In the present investigation, we used isolated porcine brain capillary endothelial cells and a flow cytometric calcein-AM assay to analyze inhibition of P-glycoprotein, a major constituent of the blood-brain barrier. We tested 8 alkamides isolated from Echinacea angustifolia and found that four of them inhibited P-glycoprotein-mediated calcein transport in porcine brain capillary endothelial cells.
- Autoren
- Anne Mahringer
- Karin Ardjomand-Woelkart
- Rudolf Bauer
- Gert Fricker
- Thomas Efferth
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/23322561
- DOI
- 10.1055/s-0032-1328090
- eISSN
- 1439-0221
- Ausgabe der Veröffentlichung
- 3-4
- Zeitschrift
- Planta Med
- Schlüsselwörter
- ATP Binding Cassette Transporter, Subfamily B
- Animals
- Biological Transport
- Blood-Brain Barrier
- Brain
- Cells, Cultured
- Dose-Response Relationship, Drug
- Echinacea
- Endothelial Cells
- Flow Cytometry
- Fluoresceins
- Molecular Structure
- Polyunsaturated Alkamides
- Swine
- Sprache
- eng
- Country
- Germany
- Paginierung
- 214 - 218
- Datum der Veröffentlichung
- 2013
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2014
- Titel
- Alkamides from Echinacea angustifolia Interact with P-glycoprotein of primary brain capillary endothelial cells isolated from porcine brain blood vessels.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 79
Data source: PubMed
- Beziehungen:
- Property of