Glycyrrhizic acid nanoparticles inhibit LPS-induced inflammatory mediators in 264.7 mouse macrophages compared with unprocessed glycyrrhizic acid

Publication type:
Journal article
Metadata:
Autoren
  • Wei Wang
  • Meng Luo
  • Yujie Fu
  • Song Wang
  • Thomas Efferth
  • Yuangang Zu
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000317922700122&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.2147/IJN.S37788
Externe Identifier
  • Clarivate Analytics Document Solution ID: 130MU
  • PubMed Identifier: 23610519
ISSN
1178-2013
Zeitschrift
INTERNATIONAL JOURNAL OF NANOMEDICINE
Schlüsselwörter
  • glycyrrhizic acid
  • nanoparticle
  • mouse macrophages RAW 264.7
  • inflammatory cytokines
Paginierung
1377 - 1383
Datum der Veröffentlichung
2013
Status
Published
Titel
Glycyrrhizic acid nanoparticles inhibit LPS-induced inflammatory mediators in 264.7 mouse macrophages compared with unprocessed glycyrrhizic acid
Sub types
  • Article
Ausgabe der Zeitschrift
8

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
DOI
10.2147/ijn.s37788
eISSN
1178-2013
Zeitschrift
International Journal of Nanomedicine
Sprache
en
Online publication date
2013
Paginierung
1377 - 1377
Status
Published online
Herausgeber
Informa UK Limited
Herausgeber URL
http://dx.doi.org/10.2147/ijn.s37788
Datum der Datenerfassung
2016
Titel
Glycyrrhizic acid nanoparticles inhibit LPS-induced inflammatory mediators in 264.7 mouse macrophages compared with unprocessed glycyrrhizic acid

Data source: Crossref

Abstract
Glycyrrhizic acid (GA), the main component of radix glycyrrhizae, has a variety of pharmacological activities. In the present study, suspensions of GA nanoparticles with the average particle size about 200 nm were prepared by a supercritical antisolvent (SAS) process. Comparative studies were undertaken using lipopolysaccardide (LPS)-stimulated mouse macrophages RAW 264.7 as in vitro inflammatory model. Several important inflammation mediators such as NO, PGE2, TNF-α and IL-6 were examined. These markers were highly stimulated by LPS and were inhibited both by nano-GA and unprocessed GA in a dose-dependent manner, especially PGE2 and TNF-α. However nano-GA and unprocessed GA inhibited NO only at a high concentration. In general, we found that GA nanoparticle suspensions exhibited much better anti-inflammatory activities compared to unprocessed GA.
Addresses
  • Key Laboratory of Forest Plant Ecology, Northeast Forestry University, Harbin, People's Republic of China.
Autoren
  • Wei Wang
  • Meng Luo
  • Yujie Fu
  • Song Wang
  • Thomas Efferth
  • Thomas Efferth
  • Yuangang Zu
DOI
10.2147/ijn.s37788
eISSN
1178-2013
Externe Identifier
  • PubMed Identifier: 23610519
  • PubMed Central ID: PMC3629880
Open access
true
ISSN
1176-9114
Zeitschrift
International journal of nanomedicine
Schlüsselwörter
  • Macrophages
  • Animals
  • Mice
  • Inflammation
  • Nitric Oxide
  • Glycyrrhizic Acid
  • Lipopolysaccharides
  • Tumor Necrosis Factor-alpha
  • Interleukin-6
  • Drug Carriers
  • Cell Survival
  • Surface Properties
  • Nanoparticles
Sprache
eng
Medium
Print-Electronic
Online publication date
2013
Open access status
Open Access
Paginierung
1377 - 1383
Datum der Veröffentlichung
2013
Status
Published
Publisher licence
CC BY-NC
Datum der Datenerfassung
2013
Titel
Glycyrrhizic acid nanoparticles inhibit LPS-induced inflammatory mediators in 264.7 mouse macrophages compared with unprocessed glycyrrhizic acid.
Sub types
  • Research Support, Non-U.S. Gov't
  • research-article
  • Journal Article
Ausgabe der Zeitschrift
8

Files

https://www.dovepress.com/getfile.php?fileID=15761 https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23610519/pdf/?tool=EBI https://europepmc.org/articles/PMC3629880?pdf=render

Data source: Europe PubMed Central

Abstract
Glycyrrhizic acid (GA), the main component of radix glycyrrhizae, has a variety of pharmacological activities. In the present study, suspensions of GA nanoparticles with the average particle size about 200 nm were prepared by a supercritical antisolvent (SAS) process. Comparative studies were undertaken using lipopolysaccardide (LPS)-stimulated mouse macrophages RAW 264.7 as in vitro inflammatory model. Several important inflammation mediators such as NO, PGE2, TNF-α and IL-6 were examined. These markers were highly stimulated by LPS and were inhibited both by nano-GA and unprocessed GA in a dose-dependent manner, especially PGE2 and TNF-α. However nano-GA and unprocessed GA inhibited NO only at a high concentration. In general, we found that GA nanoparticle suspensions exhibited much better anti-inflammatory activities compared to unprocessed GA.
Autoren
  • Wei Wang
  • Meng Luo
  • Yujie Fu
  • Song Wang
  • Thomas Efferth
  • Yuangang Zu
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/23610519
DOI
10.2147/IJN.S37788
eISSN
1178-2013
Externe Identifier
  • PubMed Central ID: PMC3629880
Zeitschrift
Int J Nanomedicine
Schlüsselwörter
  • glycyrrhizic acid
  • inflammatory cytokines
  • mouse macrophages RAW 264.7
  • nanoparticle
  • Animals
  • Cell Survival
  • Drug Carriers
  • Glycyrrhizic Acid
  • Inflammation
  • Interleukin-6
  • Lipopolysaccharides
  • Macrophages
  • Mice
  • Nanoparticles
  • Nitric Oxide
  • Surface Properties
  • Tumor Necrosis Factor-alpha
Sprache
eng
Country
New Zealand
Paginierung
1377 - 1383
PII
ijn-8-1377
Datum der Veröffentlichung
2013
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2014
Titel
Glycyrrhizic acid nanoparticles inhibit LPS-induced inflammatory mediators in 264.7 mouse macrophages compared with unprocessed glycyrrhizic acid.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
8

Data source: PubMed

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