Microwave-Assisted Synthesis of New Selenazole Derivatives with Antiproliferative Activity
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Adriana Ignat (Grozav)
- Luiza Gaina
- Victor Kuete
- Luminita Silaghi-Dumitrescu
- Thomas Efferth
- Valentin Zaharia
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000318020100070&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.3390/molecules18044679
- Externe Identifier
- Clarivate Analytics Document Solution ID: 131TV
- PubMed Identifier: 23603950
- ISSN
- 1420-3049
- Ausgabe der Veröffentlichung
- 4
- Zeitschrift
- MOLECULES
- Schlüsselwörter
- selenazole
- microwave assisted synthesis
- cytotoxicity
- Paginierung
- 4679 - 4688
- Datum der Veröffentlichung
- 2013
- Status
- Published
- Titel
- Microwave-Assisted Synthesis of New Selenazole Derivatives with Antiproliferative Activity
- Sub types
- Article
- Ausgabe der Zeitschrift
- 18
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Adriana Grozav Ignat
- Luiza Gaina
- Victor Kuete
- Luminita Silaghi-Dumitrescu
- Thomas Efferth
- Valentin Zaharia
- DOI
- 10.3390/molecules18044679
- eISSN
- 1420-3049
- Ausgabe der Veröffentlichung
- 4
- Zeitschrift
- Molecules
- Sprache
- en
- Online publication date
- 2013
- Paginierung
- 4679 - 4688
- Status
- Published online
- Herausgeber
- MDPI AG
- Herausgeber URL
- http://dx.doi.org/10.3390/molecules18044679
- Datum der Datenerfassung
- 2018
- Titel
- Microwave-Assisted Synthesis of New Selenazole Derivatives with Antiproliferative Activity
- Ausgabe der Zeitschrift
- 18
Data source: Crossref
- Abstract
- New aryl-hydrazinyl-1,3-selenazole and aroyl-hydrazonyl-1,3-selenazoles were synthesized via Hantzsch type condensation reactions of selenosemicarbazides with α-halogenocarbonyl derivatives, under classical versus microwave heating conditions. Excellent yields and shorter reaction times were obtained under irradiation conditions. The structures of the synthesized compounds were assigned based on spectroscopic data (FT-IR, ¹H-NMR), MS and elemental analysis. Selenazole derivatives were screened for their anti-proliferative effects against two leukemia cell lines (CCRF-CEM and HL60) and three carcinoma cell lines (MDA-MB231, HCT116 and U87MG).
- Addresses
- Faculty of Pharmacy, "Iuliu Hatieganu" University of Medicine and Pharmacy, RO-400012, Victor Babes 41, Cluj-Napoca, Romania. adriana.ignat@umfcluj.ro
- Autoren
- Adriana Ignat Ignat Grozav
- Luiza Gaina
- Victor Kuete
- Luminita Silaghi-Dumitrescu
- Thomas Efferth
- Thomas Efferth
- Valentin Zaharia
- DOI
- 10.3390/molecules18044679
- eISSN
- 1420-3049
- Externe Identifier
- PubMed Identifier: 23603950
- PubMed Central ID: PMC6269919
- Open access
- true
- ISSN
- 1420-3049
- Ausgabe der Veröffentlichung
- 4
- Zeitschrift
- Molecules (Basel, Switzerland)
- Schlüsselwörter
- Cell Line, Tumor
- HCT116 Cells
- HL-60 Cells
- Humans
- Organoselenium Compounds
- Azoles
- Antineoplastic Agents
- Inhibitory Concentration 50
- Cell Proliferation
- Microwaves
- Sprache
- eng
- Medium
- Electronic
- Online publication date
- 2013
- Open access status
- Open Access
- Paginierung
- 4679 - 4688
- Datum der Veröffentlichung
- 2013
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2013
- Titel
- Microwave-assisted synthesis of new selenazole derivatives with antiproliferative activity.
- Sub types
- Research Support, Non-U.S. Gov't
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 18
Files
https://www.mdpi.com/1420-3049/18/4/4679/pdf?version=1403114672 https://europepmc.org/articles/PMC6269919?pdf=render
Data source: Europe PubMed Central
- Abstract
- New aryl-hydrazinyl-1,3-selenazole and aroyl-hydrazonyl-1,3-selenazoles were synthesized via Hantzsch type condensation reactions of selenosemicarbazides with α-halogenocarbonyl derivatives, under classical versus microwave heating conditions. Excellent yields and shorter reaction times were obtained under irradiation conditions. The structures of the synthesized compounds were assigned based on spectroscopic data (FT-IR, ¹H-NMR), MS and elemental analysis. Selenazole derivatives were screened for their anti-proliferative effects against two leukemia cell lines (CCRF-CEM and HL60) and three carcinoma cell lines (MDA-MB231, HCT116 and U87MG).
- Date of acceptance
- 2013
- Autoren
- Adriana Ignat Ignat Grozav
- Luiza Gaina
- Victor Kuete
- Luminita Silaghi-Dumitrescu
- Thomas Efferth
- Valentin Zaharia
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/23603950
- DOI
- 10.3390/molecules18044679
- eISSN
- 1420-3049
- Externe Identifier
- PubMed Central ID: PMC6269919
- Ausgabe der Veröffentlichung
- 4
- Zeitschrift
- Molecules
- Schlüsselwörter
- Antineoplastic Agents
- Azoles
- Cell Line, Tumor
- Cell Proliferation
- HCT116 Cells
- HL-60 Cells
- Humans
- Inhibitory Concentration 50
- Microwaves
- Organoselenium Compounds
- Sprache
- eng
- Country
- Switzerland
- Paginierung
- 4679 - 4688
- PII
- molecules18044679
- Datum der Veröffentlichung
- 2013
- Status
- Published online
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2013
- Titel
- Microwave-assisted synthesis of new selenazole derivatives with antiproliferative activity.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 18
Data source: PubMed
- Beziehungen:
- Property of