Antiangiogenic Activity and Pharmacogenomics of Medicinal Plants from Traditional Korean Medicine

Publication type:
Journal article
Metadata:
Autoren
  • Ean-Jeong Seo
  • Victor Kuete
  • Onat Kadioglu
  • Benjamin Krusche
  • Sven Schroeder
  • Henry Johannes Greten
  • Joachim Arend
  • Ik-Soo Lee
  • Thomas Efferth
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000322636200001&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1155/2013/131306
eISSN
1741-4288
Externe Identifier
  • Clarivate Analytics Document Solution ID: 194MA
  • PubMed Identifier: 23970927
ISSN
1741-427X
Zeitschrift
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
Artikelnummer
ARTN 131306
Datum der Veröffentlichung
2013
Status
Published
Titel
Antiangiogenic Activity and Pharmacogenomics of Medicinal Plants from Traditional Korean Medicine
Sub types
  • Article
Ausgabe der Zeitschrift
2013

Data source: Web of Science (Lite)

Other metadata sources:
Abstract
<jats:p><jats:italic>Aim</jats:italic>. In the present study, we investigated the antiangiogenic properties of 59 plants used in traditional Korean medicine. Selected phytochemicals were investigated in more detail for their modes of action.<jats:italic>Methods</jats:italic>. A modified chicken-chorioallantoic-membrane (CAM) assay using quail eggs was applied to test for antiangiogenic effects of plant extracts. A molecular docking<jats:italic>in silico</jats:italic>approached the binding of plant constituents to the vascular endothelial growth factor receptors 1 and 2 (VEGFR1, VEGFR2). Microarray-based mRNA expression profiling was employed to correlate the 50% inhibition concentrations (IC<jats:sub>50</jats:sub>) of a panel of 60 NCI cell lines to these phytochemicals.<jats:italic>Results</jats:italic>. Extracts from<jats:italic>Acer mono</jats:italic>leaves,<jats:italic>Reynoutria sachalniensis</jats:italic>fruits,<jats:italic>Cinnamomum japonicum</jats:italic>stems,<jats:italic>Eurya japonica</jats:italic>leaves,<jats:italic>Adenophora racemosa</jats:italic>whole plant,<jats:italic>Caryopteris incana</jats:italic>leaves-stems, and<jats:italic>Schisandra chinensis</jats:italic>stems inhibited angiogenesis more than 50% in quail eggs. Selected phytochemicals from Korean plants were analyzed in more detail using microarray-based mRNA expression profiles and molecular docking to VEGFR1 and VEGFR2. These results indicate multifactorial modes of action of these natural products.<jats:italic>Conclusion</jats:italic>. The antiangiogenic activity of plants used in traditional Korean medicine implicates their possible application for diseases where inhibition of blood vessel formation is desired, for example, cancer, macular degeneration, diabetic retinopathy and others.</jats:p>
Autoren
  • Ean-Jeong Seo
  • Victor Kuete
  • Onat Kadioglu
  • Benjamin Krusche
  • Sven Schröder
  • Henry Johannes Greten
  • Joachim Arend
  • Ik-Soo Lee
  • Thomas Efferth
DOI
10.1155/2013/131306
eISSN
1741-4288
ISSN
1741-427X
Zeitschrift
Evidence-Based Complementary and Alternative Medicine
Sprache
en
Paginierung
1 - 13
Datum der Veröffentlichung
2013
Status
Published
Herausgeber
Hindawi Limited
Herausgeber URL
http://dx.doi.org/10.1155/2013/131306
Datum der Datenerfassung
2019
Titel
Antiangiogenic Activity and Pharmacogenomics of Medicinal Plants from Traditional Korean Medicine
Ausgabe der Zeitschrift
2013

Data source: Crossref

Abstract
Aim. In the present study, we investigated the antiangiogenic properties of 59 plants used in traditional Korean medicine. Selected phytochemicals were investigated in more detail for their modes of action. Methods. A modified chicken-chorioallantoic-membrane (CAM) assay using quail eggs was applied to test for antiangiogenic effects of plant extracts. A molecular docking in silico approached the binding of plant constituents to the vascular endothelial growth factor receptors 1 and 2 (VEGFR1, VEGFR2). Microarray-based mRNA expression profiling was employed to correlate the 50% inhibition concentrations (IC50) of a panel of 60 NCI cell lines to these phytochemicals. Results. Extracts from Acer mono leaves, Reynoutria sachalniensis fruits, Cinnamomum japonicum stems, Eurya japonica leaves, Adenophora racemosa whole plant, Caryopteris incana leaves-stems, and Schisandra chinensis stems inhibited angiogenesis more than 50% in quail eggs. Selected phytochemicals from Korean plants were analyzed in more detail using microarray-based mRNA expression profiles and molecular docking to VEGFR1 and VEGFR2. These results indicate multifactorial modes of action of these natural products. Conclusion. The antiangiogenic activity of plants used in traditional Korean medicine implicates their possible application for diseases where inhibition of blood vessel formation is desired, for example, cancer, macular degeneration, diabetic retinopathy and others.
Addresses
  • Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany.
Autoren
  • Ean-Jeong Seo
  • Victor Kuete
  • Onat Kadioglu
  • Benjamin Krusche
  • Sven Schröder
  • Henry Johannes Greten
  • Joachim Arend
  • Ik-Soo Lee
  • Thomas Efferth
  • Thomas Efferth
DOI
10.1155/2013/131306
eISSN
1741-4288
Externe Identifier
  • PubMed Identifier: 23970927
  • PubMed Central ID: PMC3736538
Open access
true
ISSN
1741-427X
Zeitschrift
Evidence-based complementary and alternative medicine : eCAM
Sprache
eng
Medium
Print-Electronic
Online publication date
2013
Open access status
Open Access
Paginierung
131306
Datum der Veröffentlichung
2013
Status
Published
Publisher licence
CC BY
Datum der Datenerfassung
2013
Titel
Antiangiogenic activity and pharmacogenomics of medicinal plants from traditional korean medicine.
Sub types
  • research-article
  • Journal Article
Ausgabe der Zeitschrift
2013

Files

https://downloads.hindawi.com/journals/ecam/2013/131306.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23970927/pdf/?tool=EBI https://europepmc.org/articles/PMC3736538?pdf=render

Data source: Europe PubMed Central

Abstract
Aim. In the present study, we investigated the antiangiogenic properties of 59 plants used in traditional Korean medicine. Selected phytochemicals were investigated in more detail for their modes of action. Methods. A modified chicken-chorioallantoic-membrane (CAM) assay using quail eggs was applied to test for antiangiogenic effects of plant extracts. A molecular docking in silico approached the binding of plant constituents to the vascular endothelial growth factor receptors 1 and 2 (VEGFR1, VEGFR2). Microarray-based mRNA expression profiling was employed to correlate the 50% inhibition concentrations (IC50) of a panel of 60 NCI cell lines to these phytochemicals. Results. Extracts from Acer mono leaves, Reynoutria sachalniensis fruits, Cinnamomum japonicum stems, Eurya japonica leaves, Adenophora racemosa whole plant, Caryopteris incana leaves-stems, and Schisandra chinensis stems inhibited angiogenesis more than 50% in quail eggs. Selected phytochemicals from Korean plants were analyzed in more detail using microarray-based mRNA expression profiles and molecular docking to VEGFR1 and VEGFR2. These results indicate multifactorial modes of action of these natural products. Conclusion. The antiangiogenic activity of plants used in traditional Korean medicine implicates their possible application for diseases where inhibition of blood vessel formation is desired, for example, cancer, macular degeneration, diabetic retinopathy and others.
Date of acceptance
2013
Autoren
  • Ean-Jeong Seo
  • Victor Kuete
  • Onat Kadioglu
  • Benjamin Krusche
  • Sven Schröder
  • Henry Johannes Greten
  • Joachim Arend
  • Ik-Soo Lee
  • Thomas Efferth
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/23970927
DOI
10.1155/2013/131306
Externe Identifier
  • PubMed Central ID: PMC3736538
ISSN
1741-427X
Zeitschrift
Evid Based Complement Alternat Med
Sprache
eng
Country
United States
Paginierung
131306
Datum der Veröffentlichung
2013
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2013
Titel
Antiangiogenic activity and pharmacogenomics of medicinal plants from traditional korean medicine.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
2013

Data source: PubMed

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