Cytotoxicity of Elaoephorbia drupifera and other Cameroonian medicinal plants against drug sensitive and multidrug resistant cancer cells
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Victor Kuete
- Igor K Voukeng
- Roger Tsobou
- Armelle T Mbaveng
- Benjamin Wiench
- Veronique P Beng
- Thomas Efferth
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000325801100005&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1186/1472-6882-13-250
- eISSN
- 1472-6882
- Externe Identifier
- Clarivate Analytics Document Solution ID: 236MK
- PubMed Identifier: 24088184
- Zeitschrift
- BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
- Schlüsselwörter
- Cameroon
- Cytotoxicity
- Elaoephorbia drupifera
- Medicinal plants
- Artikelnummer
- ARTN 250
- Datum der Veröffentlichung
- 2013
- Status
- Published
- Titel
- Cytotoxicity of <i>Elaoephorbia drupifera</i> and other Cameroonian medicinal plants against drug sensitive and multidrug resistant cancer cells
- Sub types
- Article
- Ausgabe der Zeitschrift
- 13
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Abstract
- <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>Multidrug resistance (MDR) is a major hurdle for cancer treatment worldwide and accounts for chemotherapy failure in over 90% of patients with metastatic cancer. Evidence of the cytotoxicity of Cameroonian plants against cancer cell lines including MDR phenotypes is been intensively and progressively provided. The present work was therefore designed to evaluate the cytotoxicity of the methanol extracts of twenty-two Cameroonian medicinal plants against sensitive and MDR cancer cell lines.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>The methanol maceration was used to obtain the crude plant extracts whilst the cytotoxicity of the studied extracts was determined using a resazurin reduction assay.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>A preliminary assay on leukemia CCRF-CEM cells at 40 μg/mL shows that six of the twenty plant extract were able to enhance less than 50% of the growth proliferation of CCRF-CEM cells. These include <jats:italic>Crinum zeylanicum</jats:italic> (32.22%)<jats:italic>, Entada abyssinica</jats:italic> (34.67%)<jats:italic>, Elaoephorbia drupifera</jats:italic> (35.05%)<jats:italic>, Dioscorea bulbifera</jats:italic> (45.88%)<jats:italic>, Eremomastax speciosa</jats:italic> (46.07%) and <jats:italic>Polistigma thonningii</jats:italic> (45.11%). Among these six plants, <jats:italic>E. drupifera</jats:italic> showed the best activity with IC<jats:sub>50</jats:sub> values below or around 30 μg/mL against the nine tested cancer cell lines. The lowest IC<jats:sub>50</jats:sub> value of 8.40 μg/mL was recorded with the extract of <jats:italic>E. drupifera</jats:italic> against MDA-MB231 breast cancer cell line. The IC<jats:sub>50</jats:sub> values below 10 μg/mL were recorded with the extracts of <jats:italic>E. drupifera</jats:italic> against MDA-MB231 breast cancer cells, <jats:italic>C. zeylanicum</jats:italic> against HCT116 p53<jats:sup>+</jats:sup>/<jats:sup>+</jats:sup> and HCT116p53<jats:sup>-</jats:sup>/<jats:sup>-</jats:sup> colon cancer cells and <jats:italic>E. abyssinica</jats:italic> against HCT116 p53<jats:sup>+</jats:sup>/<jats:sup>+</jats:sup> cells.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion</jats:title> <jats:p>The results of the present study provide evidence of the cytotoxic potential of some Cameroonian medicinal plants and a baseline information for the potential use of <jats:italic>Elaoephorbia drupifera</jats:italic> in the treatment of sensitive and drug-resistant cancer cell lines.</jats:p> </jats:sec>
- Autoren
- Victor Kuete
- Igor K Voukeng
- Roger Tsobou
- Armelle T Mbaveng
- Benjamin Wiench
- Veronique P Beng
- Thomas Efferth
- DOI
- 10.1186/1472-6882-13-250
- eISSN
- 1472-6882
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- BMC Complementary and Alternative Medicine
- Sprache
- en
- Artikelnummer
- 250
- Online publication date
- 2013
- Datum der Veröffentlichung
- 2013
- Status
- Published
- Herausgeber
- Springer Science and Business Media LLC
- Herausgeber URL
- http://dx.doi.org/10.1186/1472-6882-13-250
- Datum der Datenerfassung
- 2021
- Titel
- Cytotoxicity of Elaoephorbia drupifera and other Cameroonian medicinal plants against drug sensitive and multidrug resistant cancer cells
- Ausgabe der Zeitschrift
- 13
Data source: Crossref
- Abstract
- <h4>Background</h4>Multidrug resistance (MDR) is a major hurdle for cancer treatment worldwide and accounts for chemotherapy failure in over 90% of patients with metastatic cancer. Evidence of the cytotoxicity of Cameroonian plants against cancer cell lines including MDR phenotypes is been intensively and progressively provided. The present work was therefore designed to evaluate the cytotoxicity of the methanol extracts of twenty-two Cameroonian medicinal plants against sensitive and MDR cancer cell lines.<h4>Methods</h4>The methanol maceration was used to obtain the crude plant extracts whilst the cytotoxicity of the studied extracts was determined using a resazurin reduction assay.<h4>Results</h4>A preliminary assay on leukemia CCRF-CEM cells at 40 μg/mL shows that six of the twenty plant extract were able to enhance less than 50% of the growth proliferation of CCRF-CEM cells. These include Crinum zeylanicum (32.22%), Entada abyssinica (34.67%), Elaoephorbia drupifera (35.05%), Dioscorea bulbifera (45.88%), Eremomastax speciosa (46.07%) and Polistigma thonningii (45.11%). Among these six plants, E. drupifera showed the best activity with IC₅₀ values below or around 30 μg/mL against the nine tested cancer cell lines. The lowest IC₅₀ value of 8.40 μg/mL was recorded with the extract of E. drupifera against MDA-MB231 breast cancer cell line. The IC50 values below 10 μg/mL were recorded with the extracts of E. drupifera against MDA-MB231 breast cancer cells, C. zeylanicum against HCT116 p53⁺/⁺ and HCT116p53⁻/⁻ colon cancer cells and E. abyssinica against HCT116 p53⁺/⁺ cells.<h4>Conclusion</h4>The results of the present study provide evidence of the cytotoxic potential of some Cameroonian medicinal plants and a baseline information for the potential use of Elaoephorbia drupifera in the treatment of sensitive and drug-resistant cancer cell lines.
- Addresses
- Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Staudinger Weg 5, Mainz 55128, Germany. efferth@uni-mainz.de.
- Autoren
- Victor Kuete
- Igor K Voukeng
- Roger Tsobou
- Armelle T Mbaveng
- Benjamin Wiench
- Veronique P Beng
- Thomas Efferth
- Thomas Efferth
- DOI
- 10.1186/1472-6882-13-250
- eISSN
- 1472-6882
- Externe Identifier
- PubMed Identifier: 24088184
- PubMed Central ID: PMC3852045
- Open access
- true
- ISSN
- 1472-6882
- Zeitschrift
- BMC complementary and alternative medicine
- Schlüsselwörter
- Cell Line, Tumor
- HCT116 Cells
- Humans
- Euphorbia
- Plants, Medicinal
- Neoplasms
- Plant Extracts
- Drug Resistance, Multiple
- Cell Survival
- Drug Resistance, Neoplasm
- Sprache
- eng
- Medium
- Electronic
- Online publication date
- 2013
- Open access status
- Open Access
- Paginierung
- 250
- Datum der Veröffentlichung
- 2013
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2013
- Titel
- Cytotoxicity of Elaoephorbia drupifera and other Cameroonian medicinal plants against drug sensitive and multidrug resistant cancer cells.
- Sub types
- Research Support, Non-U.S. Gov't
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 13
Files
https://bmccomplementmedtherapies.biomedcentral.com/counter/pdf/10.1186/1472-6882-13-250 https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24088184/pdf/?tool=EBI https://europepmc.org/articles/PMC3852045?pdf=render
Data source: Europe PubMed Central
- Abstract
- BACKGROUND: Multidrug resistance (MDR) is a major hurdle for cancer treatment worldwide and accounts for chemotherapy failure in over 90% of patients with metastatic cancer. Evidence of the cytotoxicity of Cameroonian plants against cancer cell lines including MDR phenotypes is been intensively and progressively provided. The present work was therefore designed to evaluate the cytotoxicity of the methanol extracts of twenty-two Cameroonian medicinal plants against sensitive and MDR cancer cell lines. METHODS: The methanol maceration was used to obtain the crude plant extracts whilst the cytotoxicity of the studied extracts was determined using a resazurin reduction assay. RESULTS: A preliminary assay on leukemia CCRF-CEM cells at 40 μg/mL shows that six of the twenty plant extract were able to enhance less than 50% of the growth proliferation of CCRF-CEM cells. These include Crinum zeylanicum (32.22%), Entada abyssinica (34.67%), Elaoephorbia drupifera (35.05%), Dioscorea bulbifera (45.88%), Eremomastax speciosa (46.07%) and Polistigma thonningii (45.11%). Among these six plants, E. drupifera showed the best activity with IC₅₀ values below or around 30 μg/mL against the nine tested cancer cell lines. The lowest IC₅₀ value of 8.40 μg/mL was recorded with the extract of E. drupifera against MDA-MB231 breast cancer cell line. The IC50 values below 10 μg/mL were recorded with the extracts of E. drupifera against MDA-MB231 breast cancer cells, C. zeylanicum against HCT116 p53⁺/⁺ and HCT116p53⁻/⁻ colon cancer cells and E. abyssinica against HCT116 p53⁺/⁺ cells. CONCLUSION: The results of the present study provide evidence of the cytotoxic potential of some Cameroonian medicinal plants and a baseline information for the potential use of Elaoephorbia drupifera in the treatment of sensitive and drug-resistant cancer cell lines.
- Date of acceptance
- 2013
- Autoren
- Victor Kuete
- Igor K Voukeng
- Roger Tsobou
- Armelle T Mbaveng
- Benjamin Wiench
- Veronique P Beng
- Thomas Efferth
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/24088184
- DOI
- 10.1186/1472-6882-13-250
- eISSN
- 1472-6882
- Externe Identifier
- PubMed Central ID: PMC3852045
- Zeitschrift
- BMC Complement Altern Med
- Schlüsselwörter
- Cell Line, Tumor
- Cell Survival
- Drug Resistance, Multiple
- Drug Resistance, Neoplasm
- Euphorbia
- HCT116 Cells
- Humans
- Neoplasms
- Plant Extracts
- Plants, Medicinal
- Sprache
- eng
- Country
- England
- Paginierung
- 250
- PII
- 1472-6882-13-250
- Datum der Veröffentlichung
- 2013
- Status
- Published online
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2014
- Titel
- Cytotoxicity of Elaoephorbia drupifera and other Cameroonian medicinal plants against drug sensitive and multidrug resistant cancer cells.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 13
Data source: PubMed
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- Property of