Cytotoxicity of Novel Sulfanilamides Towards Sensitive and Multidrug-resistant Leukemia Cells
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- T AlSalim
- MEM Saeed
- JS Hadi
- M Zeino
- R Gany
- O Kadioglu
- SJJ Titinchi
- HS Abbo
- T Efferth
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000338629800012&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.2174/0929867321666140120120708
- eISSN
- 1875-533X
- Externe Identifier
- Clarivate Analytics Document Solution ID: AK7TE
- PubMed Identifier: 24438524
- ISSN
- 0929-8673
- Ausgabe der Veröffentlichung
- 23
- Zeitschrift
- CURRENT MEDICINAL CHEMISTRY
- Schlüsselwörter
- Anthraldehyde
- cancer
- cinnamaldehyde
- condensation
- isatin
- multidrug resistance
- sulpha drugs
- schiff bases
- Paginierung
- 2715 - 2725
- Datum der Veröffentlichung
- 2014
- Status
- Published
- Titel
- Cytotoxicity of Novel Sulfanilamides Towards Sensitive and Multidrug-resistant Leukemia Cells
- Sub types
- Article
- Ausgabe der Zeitschrift
- 21
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- T AlSalim
- MEM Saeed
- JS Hadi
- M Zeino
- R Gany
- O Kadioglu
- SJJ Titinchi
- HS Abbo
- T Efferth
- DOI
- 10.2174/0929867321666140120120708
- ISSN
- 0929-8673
- Ausgabe der Veröffentlichung
- 23
- Zeitschrift
- Current Medicinal Chemistry
- Sprache
- en
- Paginierung
- 2715 - 2725
- Datum der Veröffentlichung
- 2014
- Status
- Published
- Herausgeber
- Bentham Science Publishers Ltd.
- Herausgeber URL
- http://dx.doi.org/10.2174/0929867321666140120120708
- Datum der Datenerfassung
- 2015
- Titel
- Cytotoxicity of Novel Sulfanilamides Towards Sensitive and Multidrugresistant Leukemia Cells
- Ausgabe der Zeitschrift
- 21
Data source: Crossref
- Abstract
- Novel sulfa Schiff bases were synthesized and characterized by a reaction between aromatic sulfonamides and aromatic aldehydes or heterocyclic ketones in equimolar ratios. Their cytotoxicity was evaluated by the resazurin assay towards human sensitive CCRF-CEM and multidrug-resistant CEM/ADR5000 leukemia cells. Three of the tested compounds viz., 4-(anthracen-9-ylmethyleneamino)-N-(pyrimidin-2-yl)benzenesulfonamide (4), 4-(anthracen-9- ylmethyleneamino)benzenesulfonamide, (5) and 4-((3-phenylallylidene)amino)benzene-sulfonamide, (6) were cytotoxic (IC50 values: 5.38-19.96 µM). CEM/ADR5000 cells were not cross-resistant to these compounds, indicating activity against otherwise drug-resistant tumors. Compound 6 inhibited P-glycoprotein by increasing doxorubicin accumulation and reducing expression of P-glycoprotein in CEM/ADR5000 cells. A human P-glycoprotein homology model was used for molecular docking studies. Compound 6 and verapamil (a well-known P-glycoprotein inhibitor) docked with similar binding energies to the same binding pocket.
- Autoren
- T AlSalim
- MEM Saeed
- JS Hadi
- M Zeino
- R Gany
- O Kadioglu
- SJJ Titinchi
- HS Abbo
- T Efferth
- T Efferth
- DOI
- 10.2174/0929867321666140120120708
- eISSN
- 1875-533X
- Externe Identifier
- PubMed Identifier: 24438524
- Open access
- false
- ISSN
- 0929-8673
- Ausgabe der Veröffentlichung
- 23
- Zeitschrift
- Current medicinal chemistry
- Schlüsselwörter
- Cell Line, Tumor
- Humans
- Leukemia
- Sulfanilamides
- Doxorubicin
- Cell Survival
- Protein Structure, Tertiary
- Drug Resistance, Neoplasm
- Models, Molecular
- Sulfanilamide
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Sprache
- eng
- Medium
- Paginierung
- 2715 - 2725
- Datum der Veröffentlichung
- 2014
- Status
- Published
- Datum der Datenerfassung
- 2014
- Titel
- Cytotoxicity of novel sulfanilamides towards sensitive and multidrug-resistant leukemia cells.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 21
Data source: Europe PubMed Central
- Abstract
- Novel sulfa Schiff bases were synthesized and characterized by a reaction between aromatic sulfonamides and aromatic aldehydes or heterocyclic ketones in equimolar ratios. Their cytotoxicity was evaluated by the resazurin assay towards human sensitive CCRF-CEM and multidrug-resistant CEM/ADR5000 leukemia cells. Three of the tested compounds viz., 4-(anthracen-9-ylmethyleneamino)-N-(pyrimidin-2-yl)benzenesulfonamide (4), 4-(anthracen-9- ylmethyleneamino)benzenesulfonamide, (5) and 4-((3-phenylallylidene)amino)benzene-sulfonamide, (6) were cytotoxic (IC50 values: 5.38-19.96 µM). CEM/ADR5000 cells were not cross-resistant to these compounds, indicating activity against otherwise drug-resistant tumors. Compound 6 inhibited P-glycoprotein by increasing doxorubicin accumulation and reducing expression of P-glycoprotein in CEM/ADR5000 cells. A human P-glycoprotein homology model was used for molecular docking studies. Compound 6 and verapamil (a well-known P-glycoprotein inhibitor) docked with similar binding energies to the same binding pocket.
- Date of acceptance
- 2014
- Autoren
- T AlSalim
- MEM Saeed
- JS Hadi
- M Zeino
- R Gany
- O Kadioglu
- SJJ Titinchi
- HS Abbo
- T Efferth
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/24438524
- DOI
- 10.2174/0929867321666140120120708
- eISSN
- 1875-533X
- Ausgabe der Veröffentlichung
- 23
- Zeitschrift
- Curr Med Chem
- Schlüsselwörter
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Cell Line, Tumor
- Cell Survival
- Doxorubicin
- Drug Resistance, Neoplasm
- Humans
- Leukemia
- Models, Molecular
- Protein Structure, Tertiary
- Sulfanilamide
- Sulfanilamides
- Sprache
- eng
- Country
- United Arab Emirates
- Paginierung
- 2715 - 2725
- PII
- CMC-EPUB-58716
- Datum der Veröffentlichung
- 2014
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2015
- Titel
- Cytotoxicity of novel sulfanilamides towards sensitive and multidrug-resistant leukemia cells.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 21
Data source: PubMed
- Beziehungen:
- Property of