Targeting epidermal growth factor receptors and downstream signaling pathways in cancer by phytochemicals
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Onat Kadioglu
- Jingming Cao
- Mohamed EM Saeed
- Henry Johannes Greten
- Thomas Efferth
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000360766400003&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1007/s11523-014-0339-4
- eISSN
- 1776-260X
- Externe Identifier
- Clarivate Analytics Document Solution ID: CQ7ES
- PubMed Identifier: 25410594
- ISSN
- 1776-2596
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- TARGETED ONCOLOGY
- Schlüsselwörter
- Drug resistance
- Kinase
- Molecular docking
- Natural products
- Signal transduction
- Paginierung
- 337 - 353
- Datum der Veröffentlichung
- 2015
- Status
- Published
- Titel
- Targeting epidermal growth factor receptors and downstream signaling pathways in cancer by phytochemicals
- Sub types
- Review
- Ausgabe der Zeitschrift
- 10
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Onat Kadioglu
- Jingming Cao
- Mohamed EM Saeed
- Henry Johannes Greten
- Thomas Efferth
- DOI
- 10.1007/s11523-014-0339-4
- eISSN
- 1776-260X
- ISSN
- 1776-2596
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- Targeted Oncology
- Sprache
- en
- Online publication date
- 2014
- Paginierung
- 337 - 353
- Datum der Veröffentlichung
- 2015
- Status
- Published
- Herausgeber
- Springer Science and Business Media LLC
- Herausgeber URL
- http://dx.doi.org/10.1007/s11523-014-0339-4
- Datum der Datenerfassung
- 2019
- Titel
- Targeting epidermal growth factor receptors and downstream signaling pathways in cancer by phytochemicals
- Ausgabe der Zeitschrift
- 10
Data source: Crossref
- Abstract
- Epidermal growth factor receptors (EGFR, HER2, HER3) activate signal transduction pathways involved in cancer proliferation, apoptosis, differentiation, metastasis, and angiogenesis. Their overexpression and activation are associated with unfavorable prognosis of cancer patients. Therefore, they are attractive targets for cancer therapy. Due to the development of drug resistance, therapeutic monoclonal antibodies and synthetic small molecule tyrosine kinase inhibitors directed against EGFR family members may fail with fatal consequences for cancer patients. Medicinal plants raised considerable interest during the past years as valuable resources to develop novel treatment therapies targeting epidermal growth factor receptors and their downstream signal transduction pathways. The present review gives an overview of isolated phytochemicals that inhibit these signaling routes. Inhibitors have been described that down-regulate the mRNA or protein expression of EGFR, HER2, or HER3 or inhibit the phosphorylation of these receptors and/or their downstream signaling kinases. Remarkably, a wealth of in vivo experiments complemented in vitro data, indicating that natural products are also active in living animals bringing this research concept closer to clinical applicability. The combination of receptor-inhibiting natural product with standard anticancer drugs frequently caused increased or even synergistic tumor inhibition in vitro and in vivo. It deserves further evaluation, if and how epidermal growth factor receptor-targeting natural products can be integrated into clinical oncology as well as to define their role for more tumor-specific and individualized tumor therapies.
- Addresses
- Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany.
- Autoren
- Onat Kadioglu
- Jingming Cao
- Mohamed EM Saeed
- Henry Johannes Greten
- Thomas Efferth
- Thomas Efferth
- DOI
- 10.1007/s11523-014-0339-4
- eISSN
- 1776-260X
- Externe Identifier
- PubMed Identifier: 25410594
- Open access
- false
- ISSN
- 1776-2596
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- Targeted oncology
- Schlüsselwörter
- Cell Line, Tumor
- Animals
- Humans
- Mice
- Plants, Medicinal
- Neoplasms
- RNA, Messenger
- Phytotherapy
- DNA Mutational Analysis
- Medical Oncology
- Signal Transduction
- Phosphorylation
- Drug Resistance, Neoplasm
- Molecular Docking Simulation
- Phytochemicals
- ErbB Receptors
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2014
- Paginierung
- 337 - 353
- Datum der Veröffentlichung
- 2015
- Status
- Published
- Datum der Datenerfassung
- 2014
- Titel
- Targeting epidermal growth factor receptors and downstream signaling pathways in cancer by phytochemicals.
- Sub types
- Review
- Journal Article
- Ausgabe der Zeitschrift
- 10
Data source: Europe PubMed Central
- Abstract
- Epidermal growth factor receptors (EGFR, HER2, HER3) activate signal transduction pathways involved in cancer proliferation, apoptosis, differentiation, metastasis, and angiogenesis. Their overexpression and activation are associated with unfavorable prognosis of cancer patients. Therefore, they are attractive targets for cancer therapy. Due to the development of drug resistance, therapeutic monoclonal antibodies and synthetic small molecule tyrosine kinase inhibitors directed against EGFR family members may fail with fatal consequences for cancer patients. Medicinal plants raised considerable interest during the past years as valuable resources to develop novel treatment therapies targeting epidermal growth factor receptors and their downstream signal transduction pathways. The present review gives an overview of isolated phytochemicals that inhibit these signaling routes. Inhibitors have been described that down-regulate the mRNA or protein expression of EGFR, HER2, or HER3 or inhibit the phosphorylation of these receptors and/or their downstream signaling kinases. Remarkably, a wealth of in vivo experiments complemented in vitro data, indicating that natural products are also active in living animals bringing this research concept closer to clinical applicability. The combination of receptor-inhibiting natural product with standard anticancer drugs frequently caused increased or even synergistic tumor inhibition in vitro and in vivo. It deserves further evaluation, if and how epidermal growth factor receptor-targeting natural products can be integrated into clinical oncology as well as to define their role for more tumor-specific and individualized tumor therapies.
- Date of acceptance
- 2014
- Autoren
- Onat Kadioglu
- Jingming Cao
- Mohamed EM Saeed
- Henry Johannes Greten
- Thomas Efferth
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/25410594
- DOI
- 10.1007/s11523-014-0339-4
- eISSN
- 1776-260X
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- Target Oncol
- Schlüsselwörter
- Animals
- Cell Line, Tumor
- DNA Mutational Analysis
- Drug Resistance, Neoplasm
- ErbB Receptors
- Humans
- Medical Oncology
- Mice
- Molecular Docking Simulation
- Neoplasms
- Phosphorylation
- Phytochemicals
- Phytotherapy
- Plants, Medicinal
- RNA, Messenger
- Signal Transduction
- Sprache
- eng
- Country
- France
- Paginierung
- 337 - 353
- Datum der Veröffentlichung
- 2015
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2016
- Titel
- Targeting epidermal growth factor receptors and downstream signaling pathways in cancer by phytochemicals.
- Sub types
- Journal Article
- Review
- Ausgabe der Zeitschrift
- 10
Data source: PubMed
- Beziehungen:
- Property of