Synthesis and Anti-Tumor Activity of Novel Aminomethylated Derivatives of Isoliquiritigenin
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Haoran Fu
- Yuhang Zhang
- Xiqing Wang
- Yingzhi Han
- Xiao Peng
- Thomas Efferth
- Yujie Fu
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000345564300035&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.3390/molecules191117715
- Externe Identifier
- Clarivate Analytics Document Solution ID: AU4FC
- PubMed Identifier: 25365296
- ISSN
- 1420-3049
- Ausgabe der Veröffentlichung
- 11
- Zeitschrift
- MOLECULES
- Schlüsselwörter
- aminomethylated derivatives of isoliquiritigenin
- organic synthesis
- Mannich reaction
- anti-tumor activity
- Paginierung
- 17715 - 17726
- Datum der Veröffentlichung
- 2014
- Status
- Published
- Titel
- Synthesis and Anti-Tumor Activity of Novel Aminomethylated Derivatives of Isoliquiritigenin
- Sub types
- Article
- Ausgabe der Zeitschrift
- 19
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Haoran Fu
- Yuhang Zhang
- Xiqing Wang
- Yingzhi Han
- Xiao Peng
- Thomas Efferth
- Yujie Fu
- DOI
- 10.3390/molecules191117715
- eISSN
- 1420-3049
- Ausgabe der Veröffentlichung
- 11
- Zeitschrift
- Molecules
- Sprache
- en
- Online publication date
- 2014
- Paginierung
- 17715 - 17726
- Status
- Published online
- Herausgeber
- MDPI AG
- Herausgeber URL
- http://dx.doi.org/10.3390/molecules191117715
- Datum der Datenerfassung
- 2018
- Titel
- Synthesis and Anti-Tumor Activity of Novel Aminomethylated Derivatives of Isoliquiritigenin
- Ausgabe der Zeitschrift
- 19
Data source: Crossref
- Abstract
- A series of new aminomethylated derivatives of isoliquiritigenin was synthesized. The structures of the compounds were confirmed by IR, MS, NMR, 13C-NMR and elemental analyses. Cytotoxic activities of these derivatives towards the human prostatic cell line PC-3, human mammary cancer cell line MCF-7 and human oophoroma cell line HO-8910 in vitro were tested. The IC50 values showed cytotoxic activities of some of these new derivatives were relatively strong. Furthermore, tumor growth inhibition in vivo of aminomethylated derivatives of isoliquiritigenin 15 was superior to that of isoliquritigenin and reached inhibition rates of 71.68%. The detailed synthesis, spectroscopic data, biological and pharmacologicalactivities of the synthesized compounds were provided.
- Addresses
- School of Chemistry and Environment, Beihang University, Beijing 100191, China. haoran_fu2014@163.com.
- Autoren
- Haoran Fu
- Yuhang Zhang
- Xiqing Wang
- Yingzhi Han
- Xiao Peng
- Thomas Efferth
- Thomas Efferth
- Yujie Fu
- DOI
- 10.3390/molecules191117715
- eISSN
- 1420-3049
- Externe Identifier
- PubMed Identifier: 25365296
- PubMed Central ID: PMC6271340
- Open access
- true
- ISSN
- 1420-3049
- Ausgabe der Veröffentlichung
- 11
- Zeitschrift
- Molecules (Basel, Switzerland)
- Schlüsselwörter
- Cell Line, Tumor
- Animals
- Mice, Inbred BALB C
- Humans
- Mice
- Chalcones
- Antineoplastic Agents
- Magnetic Resonance Spectroscopy
- Drug Screening Assays, Antitumor
- Cell Proliferation
- Structure-Activity Relationship
- Female
- MCF-7 Cells
- Sprache
- eng
- Medium
- Electronic
- Online publication date
- 2014
- Open access status
- Open Access
- Paginierung
- 17715 - 17726
- Datum der Veröffentlichung
- 2014
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2014
- Titel
- Synthesis and anti-tumor activity of novel aminomethylated derivatives of isoliquiritigenin.
- Sub types
- Research Support, Non-U.S. Gov't
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 19
Files
https://www.mdpi.com/1420-3049/19/11/17715/pdf?version=1414751434 https://europepmc.org/articles/PMC6271340?pdf=render
Data source: Europe PubMed Central
- Abstract
- A series of new aminomethylated derivatives of isoliquiritigenin was synthesized. The structures of the compounds were confirmed by IR, MS, NMR, 13C-NMR and elemental analyses. Cytotoxic activities of these derivatives towards the human prostatic cell line PC-3, human mammary cancer cell line MCF-7 and human oophoroma cell line HO-8910 in vitro were tested. The IC50 values showed cytotoxic activities of some of these new derivatives were relatively strong. Furthermore, tumor growth inhibition in vivo of aminomethylated derivatives of isoliquiritigenin 15 was superior to that of isoliquritigenin and reached inhibition rates of 71.68%. The detailed synthesis, spectroscopic data, biological and pharmacologicalactivities of the synthesized compounds were provided.
- Date of acceptance
- 2014
- Autoren
- Haoran Fu
- Yuhang Zhang
- Xiqing Wang
- Yingzhi Han
- Xiao Peng
- Thomas Efferth
- Yujie Fu
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/25365296
- DOI
- 10.3390/molecules191117715
- eISSN
- 1420-3049
- Externe Identifier
- PubMed Central ID: PMC6271340
- Ausgabe der Veröffentlichung
- 11
- Zeitschrift
- Molecules
- Schlüsselwörter
- Animals
- Antineoplastic Agents
- Cell Line, Tumor
- Cell Proliferation
- Chalcones
- Drug Screening Assays, Antitumor
- Female
- Humans
- MCF-7 Cells
- Magnetic Resonance Spectroscopy
- Mice
- Mice, Inbred BALB C
- Structure-Activity Relationship
- Sprache
- eng
- Country
- Switzerland
- Paginierung
- 17715 - 17726
- PII
- molecules191117715
- Datum der Veröffentlichung
- 2014
- Status
- Published online
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2015
- Titel
- Synthesis and anti-tumor activity of novel aminomethylated derivatives of isoliquiritigenin.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 19
Data source: PubMed
- Beziehungen:
- Property of