Cytotoxic Benzophenanthridine and Furoquinoline Alkaloids from Zanthoxylum buesgenii (Rutaceae)
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Louis P Sandjo
- Victor Kuete
- Rodrigue S Tchangna
- Thomas Efferth
- Bonaventure T Ngadjui
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000345797300001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1186/s13065-014-0061-4
- Externe Identifier
- Clarivate Analytics Document Solution ID: AU7RJ
- PubMed Identifier: 25349626
- ISSN
- 1752-153X
- Zeitschrift
- CHEMISTRY CENTRAL JOURNAL
- Schlüsselwörter
- Zanthoxylum buesgenii
- Benzophenanthridines
- Furoquinolines
- Cytotoxicity
- Artikelnummer
- ARTN 61
- Datum der Veröffentlichung
- 2014
- Status
- Published
- Titel
- Cytotoxic Benzophenanthridine and Furoquinoline Alkaloids from <i>Zanthoxylum</i> <i>buesgenii</i> (Rutaceae)
- Sub types
- Article
- Ausgabe der Zeitschrift
- 8
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Louis P Sandjo
- Victor Kuete
- Rodrigue S Tchangna
- Thomas Efferth
- Bonaventure T Ngadjui
- DOI
- 10.1186/s13065-014-0061-4
- eISSN
- 1752-153X
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- Chemistry Central Journal
- Sprache
- en
- Artikelnummer
- 61
- Online publication date
- 2014
- Datum der Veröffentlichung
- 2014
- Status
- Published
- Herausgeber
- Springer Science and Business Media LLC
- Herausgeber URL
- http://dx.doi.org/10.1186/s13065-014-0061-4
- Datum der Datenerfassung
- 2019
- Titel
- Cytotoxic Benzophenanthridine and Furoquinoline Alkaloids from Zanthoxylum buesgenii(Rutaceae)
- Ausgabe der Zeitschrift
- 8
Data source: Crossref
- Abstract
- <h4>Background</h4>Zanthoxylum buesgenii is a shrub used in Sierra Leone as remedy to cure venereal diseases, arthritis, and rheumatism whereas leaves and barks are employed to treat leprosy and to relieve pain. In South West Region of Cameroon, the plant locally called "Mbem" by Lewoh-Lebang community, is orally given to patients as aphrodisiac decoction and to increase sperm count. Previous chemical studies on Zanthoxylum species reported the identification of lignans, coumarins, diterpenes, sesquiterpenes, steroids, alkaloids and benzopropanoids. Besides, structurally diverse compounds belonging to these classes of secondary metabolites have been reported as trypanocidal, antileishmanial, antimycobacterial and cytotoxic metabolites.<h4>Results</h4>We therefore investigated the alkaloidal constituents of Z. buesgenii. In the course of the study, two benzophenanthridines [1-methoxy-12-methyl-12,13-dihydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridine-2,13-diol (1) and isofagaridine (2)] were identified among them one new. Alongside, three known furoquinolines [maculine (3), kokusaginine (4) and teclearverdoornine (5)] were also obtained and their structures were established on the basis of their NMR data and by comparison with those previously reported. Furthermore, the cytotoxicities of metabolites (1-4) isolated in substantial amount were evaluated against a series of multidrugs-resistant cancer cell lines. While compounds 2-4 showed selective cytotoxicities, compound 1 displayed activities against all cancer cells.<h4>Conclusions</h4>The observed activities corroborate those previously reported on similar benzophenanthridine alkaloids indicating that compounds 1 and 2 can chemically be explored to develop other chemotherapeutic agents. Graphical abstractCytotoxic Benzophenanthridine and Furoquinoline Alkaloids from Zanthoxylum buesgenii (Rutaceae).
- Addresses
- Department of Organic Chemistry, University of Yaoundé I, P. O. Box 812, Yaoundé, Cameroon.
- Autoren
- Louis P Sandjo
- Victor Kuete
- Rodrigue S Tchangna
- Thomas Efferth
- Thomas Efferth
- Bonaventure T Ngadjui
- DOI
- 10.1186/s13065-014-0061-4
- eISSN
- 1752-153X
- Externe Identifier
- PubMed Identifier: 25349626
- PubMed Central ID: PMC4207896
- Open access
- true
- ISSN
- 1752-153X
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- Chemistry Central journal
- Sprache
- eng
- Medium
- Electronic-eCollection
- Online publication date
- 2014
- Open access status
- Open Access
- Paginierung
- 61
- Datum der Veröffentlichung
- 2014
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2014
- Titel
- Cytotoxic Benzophenanthridine and Furoquinoline Alkaloids from Zanthoxylum buesgenii (Rutaceae).
- Sub types
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 8
Files
https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-014-0061-4 https://europepmc.org/articles/PMC4207896?pdf=render
Data source: Europe PubMed Central
- Abstract
- BACKGROUND: Zanthoxylum buesgenii is a shrub used in Sierra Leone as remedy to cure venereal diseases, arthritis, and rheumatism whereas leaves and barks are employed to treat leprosy and to relieve pain. In South West Region of Cameroon, the plant locally called "Mbem" by Lewoh-Lebang community, is orally given to patients as aphrodisiac decoction and to increase sperm count. Previous chemical studies on Zanthoxylum species reported the identification of lignans, coumarins, diterpenes, sesquiterpenes, steroids, alkaloids and benzopropanoids. Besides, structurally diverse compounds belonging to these classes of secondary metabolites have been reported as trypanocidal, antileishmanial, antimycobacterial and cytotoxic metabolites. RESULTS: We therefore investigated the alkaloidal constituents of Z. buesgenii. In the course of the study, two benzophenanthridines [1-methoxy-12-methyl-12,13-dihydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridine-2,13-diol (1) and isofagaridine (2)] were identified among them one new. Alongside, three known furoquinolines [maculine (3), kokusaginine (4) and teclearverdoornine (5)] were also obtained and their structures were established on the basis of their NMR data and by comparison with those previously reported. Furthermore, the cytotoxicities of metabolites (1-4) isolated in substantial amount were evaluated against a series of multidrugs-resistant cancer cell lines. While compounds 2-4 showed selective cytotoxicities, compound 1 displayed activities against all cancer cells. CONCLUSIONS: The observed activities corroborate those previously reported on similar benzophenanthridine alkaloids indicating that compounds 1 and 2 can chemically be explored to develop other chemotherapeutic agents. Graphical abstractCytotoxic Benzophenanthridine and Furoquinoline Alkaloids from Zanthoxylum buesgenii (Rutaceae).
- Date of acceptance
- 2014
- Autoren
- Louis P Sandjo
- Victor Kuete
- Rodrigue S Tchangna
- Thomas Efferth
- Bonaventure T Ngadjui
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/25349626
- DOI
- 10.1186/s13065-014-0061-4
- Externe Identifier
- PubMed Central ID: PMC4207896
- ISSN
- 1752-153X
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- Chem Cent J
- Schlüsselwörter
- Benzophenanthridines
- Cytotoxicity
- Furoquinolines
- Zanthoxylum buesgenii
- Sprache
- eng
- Country
- England
- Paginierung
- 61
- PII
- 61
- Datum der Veröffentlichung
- 2014
- Status
- Published online
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2014
- Titel
- Cytotoxic Benzophenanthridine and Furoquinoline Alkaloids from Zanthoxylum buesgenii (Rutaceae).
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 8
Data source: PubMed
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- Property of