Aptamers as a novel tool for diagnostics and therapy
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Onat Kadioglu
- Anna Helena Malczyk
- Henry Johannes Greten
- Thomas Efferth
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000352444600027&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1007/s10637-015-0213-y
- eISSN
- 1573-0646
- Externe Identifier
- Clarivate Analytics Document Solution ID: CF3JK
- PubMed Identifier: 25637166
- ISSN
- 0167-6997
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- INVESTIGATIONAL NEW DRUGS
- Schlüsselwörter
- SELEX
- Targeted therapy
- Biosensor
- Molecular diagnostics
- Peptides
- Paginierung
- 513 - 520
- Datum der Veröffentlichung
- 2015
- Status
- Published
- Titel
- Aptamers as a novel tool for diagnostics and therapy
- Sub types
- Review
- Ausgabe der Zeitschrift
- 33
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Onat Kadioglu
- Anna Helena Malczyk
- Henry Johannes Greten
- Thomas Efferth
- DOI
- 10.1007/s10637-015-0213-y
- eISSN
- 1573-0646
- ISSN
- 0167-6997
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- Investigational New Drugs
- Sprache
- en
- Online publication date
- 2015
- Paginierung
- 513 - 520
- Datum der Veröffentlichung
- 2015
- Status
- Published
- Herausgeber
- Springer Science and Business Media LLC
- Herausgeber URL
- http://dx.doi.org/10.1007/s10637-015-0213-y
- Datum der Datenerfassung
- 2023
- Titel
- Aptamers as a novel tool for diagnostics and therapy
- Ausgabe der Zeitschrift
- 33
Data source: Crossref
- Abstract
- Aptamers are short single-stranded DNA or RNA oligonucleotides that are capable of binding small molecules, proteins, or nucleotides with high specificity. They show a stable conformation and high binding affinity for their target molecules. There are numerous applications for aptamers in biotechnology, molecular diagnostics and targeted therapy of diseases. Their production is cheap, and they generally display lower immunogenicity than monoclonal antibodies. In the present review, we give an introduction to the preparation of aptamers and provide examples for their use in biotechnology, diagnostics and therapy of diseases.
- Addresses
- Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Staudinger Weg 5, 55128, Mainz, Germany.
- Autoren
- Onat Kadioglu
- Anna Helena Malczyk
- Henry Johannes Greten
- Thomas Efferth
- Thomas Efferth
- DOI
- 10.1007/s10637-015-0213-y
- eISSN
- 1573-0646
- Externe Identifier
- PubMed Identifier: 25637166
- Open access
- false
- ISSN
- 0167-6997
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- Investigational new drugs
- Schlüsselwörter
- Humans
- DNA, Single-Stranded
- Diagnostic Techniques and Procedures
- Chromatography, Affinity
- Substance Abuse Detection
- Gene Library
- Biomedical Research
- Aptamers, Nucleotide
- Biomarkers
- Cellular Reprogramming Techniques
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2015
- Paginierung
- 513 - 520
- Datum der Veröffentlichung
- 2015
- Status
- Published
- Datum der Datenerfassung
- 2015
- Titel
- Aptamers as a novel tool for diagnostics and therapy.
- Sub types
- Review
- Journal Article
- Ausgabe der Zeitschrift
- 33
Data source: Europe PubMed Central
- Abstract
- Aptamers are short single-stranded DNA or RNA oligonucleotides that are capable of binding small molecules, proteins, or nucleotides with high specificity. They show a stable conformation and high binding affinity for their target molecules. There are numerous applications for aptamers in biotechnology, molecular diagnostics and targeted therapy of diseases. Their production is cheap, and they generally display lower immunogenicity than monoclonal antibodies. In the present review, we give an introduction to the preparation of aptamers and provide examples for their use in biotechnology, diagnostics and therapy of diseases.
- Date of acceptance
- 2015
- Autoren
- Onat Kadioglu
- Anna Helena Malczyk
- Henry Johannes Greten
- Thomas Efferth
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/25637166
- DOI
- 10.1007/s10637-015-0213-y
- eISSN
- 1573-0646
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- Invest New Drugs
- Schlüsselwörter
- Aptamers, Nucleotide
- Biomarkers
- Biomedical Research
- Cellular Reprogramming Techniques
- Chromatography, Affinity
- DNA, Single-Stranded
- Diagnostic Techniques and Procedures
- Gene Library
- Humans
- Substance Abuse Detection
- Sprache
- eng
- Country
- United States
- Paginierung
- 513 - 520
- Datum der Veröffentlichung
- 2015
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2016
- Titel
- Aptamers as a novel tool for diagnostics and therapy.
- Sub types
- Journal Article
- Review
- Ausgabe der Zeitschrift
- 33
Data source: PubMed
- Beziehungen:
- Property of