Cytotoxicity of medicinal plants of the West-Canadian Gwich'in Native Americans towards sensitive and multidrug-resistant cancer cells
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Asuman Karadeniz
- Gladys Alexie
- Henry Johannes Greten
- Kai Andersch
- Thomas Efferth
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000356555800023&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1016/j.jep.2015.03.052
- Externe Identifier
- Clarivate Analytics Document Solution ID: CK9JG
- PubMed Identifier: 25839116
- ISSN
- 0378-8741
- Zeitschrift
- JOURNAL OF ETHNOPHARMACOLOGY
- Schlüsselwörter
- ABC transporter
- Cancer
- First nations
- Multidrug resistance
- Pharmacognosy
- Paginierung
- 191 - 200
- Datum der Veröffentlichung
- 2015
- Status
- Published
- Titel
- Cytotoxicity of medicinal plants of the West-Canadian Gwich'in Native Americans towards sensitive and multidrug-resistant cancer cells
- Sub types
- Article
- Ausgabe der Zeitschrift
- 168
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Asuman Karadeniz
- Gladys Alexie
- Henry Johannes Greten
- Kai Andersch
- Thomas Efferth
- DOI
- 10.1016/j.jep.2015.03.052
- ISSN
- 0378-8741
- Zeitschrift
- Journal of Ethnopharmacology
- Sprache
- en
- Paginierung
- 191 - 200
- Datum der Veröffentlichung
- 2015
- Status
- Published
- Herausgeber
- Elsevier BV
- Herausgeber URL
- http://dx.doi.org/10.1016/j.jep.2015.03.052
- Datum der Datenerfassung
- 2018
- Titel
- Cytotoxicity of medicinal plants of the West-Canadian Gwich׳in Native Americans towards sensitive and multidrug-resistant cancer cells
- Ausgabe der Zeitschrift
- 168
Data source: Crossref
- Abstract
- <h4>Ethnopharmacological relevance</h4>Traditional medicine of the Native Americans has a long tradition of medicinal plants, which also influenced modern oncology. For instance, podophyllotoxin the active ingredient of Podophyllum peltatum L. (Berberidaceae) used by Native Americans to treat warts led to the development of etoposide and teniposide. In the present investigation, we studied 10 medicinal plants used by the Gwich׳in First Nation of West-Canada, which have been used against diverse diseases including cancer.<h4>Material and methods</h4>Sensitive and multidrug-resistant (MDR) tumor cell lines expressing various ATP-binding cassette (ABC) transporters (P-glycoprotein/ABCB1/MDR1, MRP1/ABCC1, or BCRP/ABCG2) have been used. Cytotoxicity was determined by the resazurin assay.<h4>Results</h4>Arctium minus Bernh. (Asteraceae). Lysichiton americanus Hultén & St. John (Araceae), and Maianthemum dilatatum (Alph.Wood) A.Nelson & J.F.Macbr.(Asparagaceae) were cytotoxic with IC50 values ranging from 2.40 to 86.35 µg/mL. The MDR cell lines did not exert cross-resistance to these extracts.<h4>Conclusion</h4>As these medicinal plants of the West-Canadian Gwich׳in First Nation were not involved in classical drug resistance mechanisms and might therefore be valuable to bypass anticancer drug resistance in refractory tumors.
- Addresses
- Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany; Mehmet Akif Ersoy University, Biology Department, Burdur, Turkey.
- Autoren
- Asuman Karadeniz
- Gladys Alexie
- Henry Johannes Greten
- Kai Andersch
- Thomas Efferth
- Thomas Efferth
- DOI
- 10.1016/j.jep.2015.03.052
- eISSN
- 1872-7573
- Externe Identifier
- PubMed Identifier: 25839116
- Open access
- false
- ISSN
- 0378-8741
- Zeitschrift
- Journal of ethnopharmacology
- Schlüsselwörter
- Cell Line, Tumor
- Humans
- Araceae
- Arctium
- Liliaceae
- Plants, Medicinal
- ATP-Binding Cassette Transporters
- Plant Extracts
- Antineoplastic Agents
- Drug Resistance, Multiple
- Cell Survival
- Drug Resistance, Neoplasm
- Indians, North American
- Canada
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2015
- Paginierung
- 191 - 200
- Datum der Veröffentlichung
- 2015
- Status
- Published
- Datum der Datenerfassung
- 2015
- Titel
- Cytotoxicity of medicinal plants of the West-Canadian Gwich׳in Native Americans towards sensitive and multidrug-resistant cancer cells.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 168
Data source: Europe PubMed Central
- Abstract
- ETHNOPHARMACOLOGICAL RELEVANCE: Traditional medicine of the Native Americans has a long tradition of medicinal plants, which also influenced modern oncology. For instance, podophyllotoxin the active ingredient of Podophyllum peltatum L. (Berberidaceae) used by Native Americans to treat warts led to the development of etoposide and teniposide. In the present investigation, we studied 10 medicinal plants used by the Gwich׳in First Nation of West-Canada, which have been used against diverse diseases including cancer. MATERIAL AND METHODS: Sensitive and multidrug-resistant (MDR) tumor cell lines expressing various ATP-binding cassette (ABC) transporters (P-glycoprotein/ABCB1/MDR1, MRP1/ABCC1, or BCRP/ABCG2) have been used. Cytotoxicity was determined by the resazurin assay. RESULTS: Arctium minus Bernh. (Asteraceae). Lysichiton americanus Hultén & St. John (Araceae), and Maianthemum dilatatum (Alph.Wood) A.Nelson & J.F.Macbr.(Asparagaceae) were cytotoxic with IC50 values ranging from 2.40 to 86.35 µg/mL. The MDR cell lines did not exert cross-resistance to these extracts. CONCLUSION: As these medicinal plants of the West-Canadian Gwich׳in First Nation were not involved in classical drug resistance mechanisms and might therefore be valuable to bypass anticancer drug resistance in refractory tumors.
- Date of acceptance
- 2015
- Autoren
- Asuman Karadeniz
- Gladys Alexie
- Henry Johannes Greten
- Kai Andersch
- Thomas Efferth
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/25839116
- DOI
- 10.1016/j.jep.2015.03.052
- eISSN
- 1872-7573
- Zeitschrift
- J Ethnopharmacol
- Schlüsselwörter
- ABC transporter
- Cancer
- First nations
- Multidrug resistance
- Pharmacognosy
- ATP-Binding Cassette Transporters
- Antineoplastic Agents
- Araceae
- Arctium
- Canada
- Cell Line, Tumor
- Cell Survival
- Drug Resistance, Multiple
- Drug Resistance, Neoplasm
- Humans
- Indians, North American
- Liliaceae
- Plant Extracts
- Plants, Medicinal
- Sprache
- eng
- Country
- Ireland
- Paginierung
- 191 - 200
- PII
- S0378-8741(15)00204-4
- Datum der Veröffentlichung
- 2015
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2016
- Titel
- Cytotoxicity of medicinal plants of the West-Canadian Gwich׳in Native Americans towards sensitive and multidrug-resistant cancer cells.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 168
Data source: PubMed
- Beziehungen:
- Property of