African Flora Has the Potential to Fight Multidrug Resistance of Cancer

Publication type:
Journal article
Metadata:
Autoren
  • Victor Kuete
  • Thomas Efferth
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000353499600001&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1155/2015/914813
eISSN
2314-6141
Externe Identifier
  • Clarivate Analytics Document Solution ID: CG7QN
  • PubMed Identifier: 25961047
ISSN
2314-6133
Zeitschrift
BIOMED RESEARCH INTERNATIONAL
Artikelnummer
ARTN 914813
Datum der Veröffentlichung
2015
Status
Published
Titel
African Flora Has the Potential to Fight Multidrug Resistance of Cancer
Sub types
  • Review
Ausgabe der Zeitschrift
2015

Data source: Web of Science (Lite)

Other metadata sources:
Abstract
<jats:p><jats:italic>Background</jats:italic>. Continuous efforts from scientists of diverse fields are necessary not only to better understand the mechanism by which multidrug-resistant (MDR) cancer cells occur, but also to boost the discovery of new cytotoxic compounds to fight MDR phenotypes.<jats:italic>Objectives</jats:italic>. The present review reports on the contribution of African flora in the discovery of potential cytotoxic phytochemicals against MDR cancer cells.<jats:italic>Methodology</jats:italic>. Scientific databases such as PubMed, ScienceDirect, Scopus, Google Scholar, and Web of Knowledge were used to retrieve publications related to African plants, isolated compounds, and drug resistant cancer cells. The data were analyzed to highlight cytotoxicity and the modes of actions of extracts and compounds of the most prominent African plants. Also, thresholds and cutoff points for the cytotoxicity and modes of action of phytochemicals have been provided.<jats:italic>Results</jats:italic>. Most published data related to the antiproliferative potential of African medicinal plants were from Cameroon, Egypt, Nigeria, or Madagascar. The cytotoxicity of phenolic compounds isolated in African plants was generally much better documented than that of terpenoids and alkaloids.<jats:italic>Conclusion</jats:italic>. African flora represents an enormous resource for novel cytotoxic compounds. To unravel the full potential, efforts should be strengthened throughout the continent, to meet the challenge of a successful fight against MDR cancers.</jats:p>
Autoren
  • Victor Kuete
  • Thomas Efferth
DOI
10.1155/2015/914813
eISSN
2314-6141
ISSN
2314-6133
Zeitschrift
BioMed Research International
Sprache
en
Paginierung
1 - 24
Datum der Veröffentlichung
2015
Status
Published
Herausgeber
Hindawi Limited
Herausgeber URL
http://dx.doi.org/10.1155/2015/914813
Datum der Datenerfassung
2019
Titel
African Flora Has the Potential to Fight Multidrug Resistance of Cancer
Ausgabe der Zeitschrift
2015

Data source: Crossref

Abstract
<h4>Background</h4>Continuous efforts from scientists of diverse fields are necessary not only to better understand the mechanism by which multidrug-resistant (MDR) cancer cells occur, but also to boost the discovery of new cytotoxic compounds to fight MDR phenotypes.<h4>Objectives</h4>The present review reports on the contribution of African flora in the discovery of potential cytotoxic phytochemicals against MDR cancer cells. Methodology. Scientific databases such as PubMed, ScienceDirect, Scopus, Google Scholar, and Web of Knowledge were used to retrieve publications related to African plants, isolated compounds, and drug resistant cancer cells. The data were analyzed to highlight cytotoxicity and the modes of actions of extracts and compounds of the most prominent African plants. Also, thresholds and cutoff points for the cytotoxicity and modes of action of phytochemicals have been provided.<h4>Results</h4>Most published data related to the antiproliferative potential of African medicinal plants were from Cameroon, Egypt, Nigeria, or Madagascar. The cytotoxicity of phenolic compounds isolated in African plants was generally much better documented than that of terpenoids and alkaloids.<h4>Conclusion</h4>African flora represents an enormous resource for novel cytotoxic compounds. To unravel the full potential, efforts should be strengthened throughout the continent, to meet the challenge of a successful fight against MDR cancers.
Addresses
  • Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Staudinger Weg 5, 55128 Mainz, Germany ; Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
Autoren
DOI
10.1155/2015/914813
eISSN
2314-6141
Externe Identifier
  • PubMed Identifier: 25961047
  • PubMed Central ID: PMC4413252
Open access
true
ISSN
2314-6133
Zeitschrift
BioMed research international
Schlüsselwörter
  • Humans
  • Plants, Medicinal
  • Neoplasms
  • Alkaloids
  • Plant Extracts
  • Antineoplastic Agents, Phytogenic
  • Drug Resistance, Multiple
  • Apoptosis
  • Drug Resistance, Neoplasm
  • Egypt
  • Cameroon
  • Nigeria
  • Madagascar
  • Membrane Potential, Mitochondrial
Sprache
eng
Medium
Print-Electronic
Online publication date
2015
Open access status
Open Access
Paginierung
914813
Datum der Veröffentlichung
2015
Status
Published
Publisher licence
CC BY
Datum der Datenerfassung
2015
Titel
African flora has the potential to fight multidrug resistance of cancer.
Sub types
  • Research Support, Non-U.S. Gov't
  • research-article
  • Review
  • Journal Article
Ausgabe der Zeitschrift
2015

Files

https://downloads.hindawi.com/journals/bmri/2015/914813.pdf https://europepmc.org/articles/PMC4413252?pdf=render

Data source: Europe PubMed Central

Abstract
BACKGROUND: Continuous efforts from scientists of diverse fields are necessary not only to better understand the mechanism by which multidrug-resistant (MDR) cancer cells occur, but also to boost the discovery of new cytotoxic compounds to fight MDR phenotypes. OBJECTIVES: The present review reports on the contribution of African flora in the discovery of potential cytotoxic phytochemicals against MDR cancer cells. Methodology. Scientific databases such as PubMed, ScienceDirect, Scopus, Google Scholar, and Web of Knowledge were used to retrieve publications related to African plants, isolated compounds, and drug resistant cancer cells. The data were analyzed to highlight cytotoxicity and the modes of actions of extracts and compounds of the most prominent African plants. Also, thresholds and cutoff points for the cytotoxicity and modes of action of phytochemicals have been provided. RESULTS: Most published data related to the antiproliferative potential of African medicinal plants were from Cameroon, Egypt, Nigeria, or Madagascar. The cytotoxicity of phenolic compounds isolated in African plants was generally much better documented than that of terpenoids and alkaloids. CONCLUSION: African flora represents an enormous resource for novel cytotoxic compounds. To unravel the full potential, efforts should be strengthened throughout the continent, to meet the challenge of a successful fight against MDR cancers.
Date of acceptance
2015
Autoren
  • Victor Kuete
  • Thomas Efferth
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/25961047
DOI
10.1155/2015/914813
eISSN
2314-6141
Externe Identifier
  • PubMed Central ID: PMC4413252
Zeitschrift
Biomed Res Int
Schlüsselwörter
  • Alkaloids
  • Antineoplastic Agents, Phytogenic
  • Apoptosis
  • Cameroon
  • Drug Resistance, Multiple
  • Drug Resistance, Neoplasm
  • Egypt
  • Humans
  • Madagascar
  • Membrane Potential, Mitochondrial
  • Neoplasms
  • Nigeria
  • Plant Extracts
  • Plants, Medicinal
Sprache
eng
Country
United States
Paginierung
914813
Datum der Veröffentlichung
2015
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2016
Titel
African flora has the potential to fight multidrug resistance of cancer.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review
Ausgabe der Zeitschrift
2015

Data source: PubMed

Beziehungen:
Property of

Tools