Novel sequential stress model for functional dyspepsia: Efficacy of the herbal preparation STW5

Publication type:
Journal article
Metadata:
Autoren
  • Heba Abdel-Aziz
  • Walaa Wadie
  • Hala F Zaki
  • Juergen Mueller
  • Olaf Kelber
  • Thomas Efferth
  • Mohamed T Khayyal
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000354605000010&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.phymed.2015.03.012
eISSN
1618-095X
Externe Identifier
  • Clarivate Analytics Document Solution ID: CI2VH
  • PubMed Identifier: 25981926
ISSN
0944-7113
Ausgabe der Veröffentlichung
5
Zeitschrift
PHYTOMEDICINE
Schlüsselwörter
  • Functional dyspepsia
  • Gastric accommodation
  • STW5
  • Neonatal maternal separation
  • Restraint stress
  • Ghrelin
Paginierung
588 - 595
Datum der Veröffentlichung
2015
Status
Published
Titel
Novel sequential stress model for functional dyspepsia: Efficacy of the herbal preparation STW5
Sub types
  • Article
Ausgabe der Zeitschrift
22

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Heba Abdel-Aziz
  • Walaa Wadie
  • Hala F Zaki
  • Jürgen Müller
  • Olaf Kelber
  • Thomas Efferth
  • Mohamed T Khayyal
DOI
10.1016/j.phymed.2015.03.012
ISSN
0944-7113
Ausgabe der Veröffentlichung
5
Zeitschrift
Phytomedicine
Sprache
en
Paginierung
588 - 595
Datum der Veröffentlichung
2015
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.phymed.2015.03.012
Datum der Datenerfassung
2018
Titel
Novel sequential stress model for functional dyspepsia: Efficacy of the herbal preparation STW5
Ausgabe der Zeitschrift
22

Data source: Crossref

Abstract
<h4>Background</h4>Many screening procedures for agents with potential usefulness in functional dyspepsia (FD) rely on animals exposed to stress early in life (neonatal maternal separation, NMS) or in adulthood (restraint stress, RS).<h4>Purpose</h4>Since many clinical cases of FD have been associated with stress in early life followed by stress in adulthood, a sequential model simulating the clinical situation is described. To explore the validity of the model, the efficacy of STW5, a multicomponent herbal preparation of proven usefulness in FD, was tested.<h4>Study design/methods</h4>A sequential stress model established where rats are exposed to NMS after birth followed later by RS in adulthood. Stress hormones and ghrelin were measured in plasma, while responsiveness of stomach fundus strips to smooth muscle stimulants and relaxants was assessed ex-vivo. The effectiveness of treatment with STW5 a few days before and during exposure to RS in preventing changes induced by the stress model is reported and compared to its efficacy when used in animals subjected to RS alone.<h4>Results</h4>Responses to both stimulants and relaxants were reduced to various extents in the studied models, but treatment with STW5 tended to normalize gastric responsiveness. Plasma levels of ghrelin, corticosterone releasing factor, and corticosterone were raised by RS as well as the sequential model. Treatment with STW5 tended to prevent the deranged parameters.<h4>Conclusion</h4>The sequential stress model has a place in drug screening for potential usefulness in FD as it simulates more the clinical setting. Furthermore, the findings shed more light on the mechanisms of action of STW5 in FD.
Addresses
  • Scientific Department, Steigerwald Arzneimittelwerk GmbH, Darmstadt, Germany; Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany. Electronic address: heba.abdelaziz@gmail.com.
Autoren
  • Heba Abdel-Aziz
  • Walaa Wadie
  • Hala F Zaki
  • Jürgen Müller
  • Olaf Kelber
  • Thomas Efferth
  • Thomas Efferth
  • Mohamed T Khayyal
DOI
10.1016/j.phymed.2015.03.012
eISSN
1618-095X
Externe Identifier
  • PubMed Identifier: 25981926
Open access
false
ISSN
0944-7113
Ausgabe der Veröffentlichung
5
Zeitschrift
Phytomedicine : international journal of phytotherapy and phytopharmacology
Schlüsselwörter
  • Animals
  • Rats
  • Rats, Wistar
  • Disease Models, Animal
  • Dyspepsia
  • Corticosterone
  • Corticotropin-Releasing Hormone
  • Plant Extracts
  • Restraint, Physical
  • Stress, Psychological
  • Maternal Deprivation
  • Gastrointestinal Motility
  • Female
  • Male
  • Ghrelin
Sprache
eng
Medium
Print-Electronic
Online publication date
2015
Paginierung
588 - 595
Datum der Veröffentlichung
2015
Status
Published
Publisher licence
CC BY-NC-ND
Datum der Datenerfassung
2015
Titel
Novel sequential stress model for functional dyspepsia: Efficacy of the herbal preparation STW5.
Sub types
  • Research Support, Non-U.S. Gov't
  • Journal Article
Ausgabe der Zeitschrift
22

Data source: Europe PubMed Central

Abstract
BACKGROUND: Many screening procedures for agents with potential usefulness in functional dyspepsia (FD) rely on animals exposed to stress early in life (neonatal maternal separation, NMS) or in adulthood (restraint stress, RS). PURPOSE: Since many clinical cases of FD have been associated with stress in early life followed by stress in adulthood, a sequential model simulating the clinical situation is described. To explore the validity of the model, the efficacy of STW5, a multicomponent herbal preparation of proven usefulness in FD, was tested. STUDY DESIGN/METHODS: A sequential stress model established where rats are exposed to NMS after birth followed later by RS in adulthood. Stress hormones and ghrelin were measured in plasma, while responsiveness of stomach fundus strips to smooth muscle stimulants and relaxants was assessed ex-vivo. The effectiveness of treatment with STW5 a few days before and during exposure to RS in preventing changes induced by the stress model is reported and compared to its efficacy when used in animals subjected to RS alone. RESULTS: Responses to both stimulants and relaxants were reduced to various extents in the studied models, but treatment with STW5 tended to normalize gastric responsiveness. Plasma levels of ghrelin, corticosterone releasing factor, and corticosterone were raised by RS as well as the sequential model. Treatment with STW5 tended to prevent the deranged parameters. CONCLUSION: The sequential stress model has a place in drug screening for potential usefulness in FD as it simulates more the clinical setting. Furthermore, the findings shed more light on the mechanisms of action of STW5 in FD.
Date of acceptance
2015
Autoren
  • Heba Abdel-Aziz
  • Walaa Wadie
  • Hala F Zaki
  • Jürgen Müller
  • Olaf Kelber
  • Thomas Efferth
  • Mohamed T Khayyal
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/25981926
DOI
10.1016/j.phymed.2015.03.012
eISSN
1618-095X
Ausgabe der Veröffentlichung
5
Zeitschrift
Phytomedicine
Schlüsselwörter
  • Functional dyspepsia
  • Gastric accommodation
  • Ghrelin
  • Neonatal maternal separation
  • Restraint stress
  • STW5
  • Animals
  • Corticosterone
  • Corticotropin-Releasing Hormone
  • Disease Models, Animal
  • Dyspepsia
  • Female
  • Gastrointestinal Motility
  • Ghrelin
  • Male
  • Maternal Deprivation
  • Plant Extracts
  • Rats
  • Rats, Wistar
  • Restraint, Physical
  • Stress, Psychological
Sprache
eng
Country
Germany
Paginierung
588 - 595
PII
S0944-7113(15)00078-1
Datum der Veröffentlichung
2015
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2015
Titel
Novel sequential stress model for functional dyspepsia: Efficacy of the herbal preparation STW5.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
22

Data source: PubMed

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