New efficient artemisinin derived agents against human leukemia cells, human cytomegalovirus and Plasmodium falciparum: 2nd generation 1,2,4-trioxane-ferrocene hybrids
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Christoph Reiter
- Tony Froehlich
- Maen Zeino
- Manfred Marschall
- Hanife Bahsi
- Maria Leidenberger
- Oliver Friedrich
- Barbara Kappes
- Frank Hampel
- Thomas Efferth
- Svetlana B Tsogoeva
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000356734600014&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1016/j.ejmech.2015.04.053
- eISSN
- 1768-3254
- Externe Identifier
- Clarivate Analytics Document Solution ID: CL1WC
- PubMed Identifier: 25965779
- ISSN
- 0223-5234
- Zeitschrift
- EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Schlüsselwörter
- Artemisinin
- Ferrocene
- Hybrid
- Cancer
- Malaria
- Human cytomegalovirus
- Paginierung
- 164 - 172
- Datum der Veröffentlichung
- 2015
- Status
- Published
- Titel
- New efficient artemisinin derived agents against human leukemia cells, human cytomegalovirus and <i>Plasmodium falciparum</i>: 2nd generation 1,2,4-trioxane-ferrocene hybrids
- Sub types
- Article
- Ausgabe der Zeitschrift
- 97
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Christoph Reiter
- Tony Fröhlich
- Maen Zeino
- Manfred Marschall
- Hanife Bahsi
- Maria Leidenberger
- Oliver Friedrich
- Barbara Kappes
- Frank Hampel
- Thomas Efferth
- Svetlana B Tsogoeva
- DOI
- 10.1016/j.ejmech.2015.04.053
- ISSN
- 0223-5234
- Zeitschrift
- European Journal of Medicinal Chemistry
- Sprache
- en
- Paginierung
- 164 - 172
- Datum der Veröffentlichung
- 2015
- Status
- Published
- Herausgeber
- Elsevier BV
- Herausgeber URL
- http://dx.doi.org/10.1016/j.ejmech.2015.04.053
- Datum der Datenerfassung
- 2020
- Titel
- New efficient artemisinin derived agents against human leukemia cells, human cytomegalovirus and Plasmodium falciparum: 2nd generation 1,2,4-trioxane-ferrocene hybrids
- Ausgabe der Zeitschrift
- 97
Data source: Crossref
- Abstract
- In our ongoing search for highly active hybrid molecules exceeding their parent compounds in anticancer, antimalaria as well as antiviral activity and being an alternative to the standard drugs, we present the synthesis and biological investigations of 2nd generation 1,2,4-trioxane-ferrocene hybrids. In vitro tests against the CCRF-CEM leukemia cell line revealed di-1,2,4-trioxane-ferrocene hybrid 7 as the most active compound (IC50 of 0.01 μM). Regarding the activity against the multidrug resistant subline CEM/ADR5000, 1,2,4-trioxane-ferrocene hybrid 5 showed a remarkable activity (IC50 of 0.53 μM). Contrary to the antimalaria activity of hybrids 4-8 against Plasmodium falciparum 3D7 strain with slightly higher IC50 values (between 7.2 and 30.2 nM) than that of their parent compound DHA, hybrids 5-7 possessed very promising activity (IC50 values lower than 0.5 μM) against human cytomegalovirus (HCMV). The application of 1,2,4-trioxane-ferrocene hybrids against HCMV is unprecedented and demonstrated here for the first time.
- Addresses
- Department of Chemistry and Pharmacy, Organic Chemistry Chair I and Interdisciplinary Center for Molecular Materials (ICMM), University of Erlangen-Nuremberg, Henkestraße 42, 91054 Erlangen, Germany.
- Autoren
- Christoph Reiter
- Tony Fröhlich
- Maen Zeino
- Manfred Marschall
- Hanife Bahsi
- Maria Leidenberger
- Oliver Friedrich
- Barbara Kappes
- Frank Hampel
- Thomas Efferth
- Thomas Efferth
- Svetlana B Tsogoeva
- DOI
- 10.1016/j.ejmech.2015.04.053
- eISSN
- 1768-3254
- Externe Identifier
- PubMed Identifier: 25965779
- Funding acknowledgements
- Wilhelm Sander-Stiftung: 2011.085.1
- Wilhelm Sander-Stiftung: 2011.085.2
- Deutsche Forschungsgemeinschaft: MA 1289/7-1
- Open access
- false
- ISSN
- 0223-5234
- Zeitschrift
- European journal of medicinal chemistry
- Schlüsselwörter
- Cell Line, Tumor
- Humans
- Plasmodium falciparum
- Leukemia
- Ferrous Compounds
- Artemisinins
- Heterocyclic Compounds
- Inhibitory Concentration 50
- Drug Resistance, Multiple
- Heterocyclic Compounds, 4 or More Rings
- Metallocenes
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2015
- Paginierung
- 164 - 172
- Datum der Veröffentlichung
- 2015
- Status
- Published
- Datum der Datenerfassung
- 2015
- Titel
- New efficient artemisinin derived agents against human leukemia cells, human cytomegalovirus and Plasmodium falciparum: 2nd generation 1,2,4-trioxane-ferrocene hybrids.
- Sub types
- Research Support, Non-U.S. Gov't
- Journal Article
- Ausgabe der Zeitschrift
- 97
Data source: Europe PubMed Central
- Abstract
- In our ongoing search for highly active hybrid molecules exceeding their parent compounds in anticancer, antimalaria as well as antiviral activity and being an alternative to the standard drugs, we present the synthesis and biological investigations of 2nd generation 1,2,4-trioxane-ferrocene hybrids. In vitro tests against the CCRF-CEM leukemia cell line revealed di-1,2,4-trioxane-ferrocene hybrid 7 as the most active compound (IC50 of 0.01 μM). Regarding the activity against the multidrug resistant subline CEM/ADR5000, 1,2,4-trioxane-ferrocene hybrid 5 showed a remarkable activity (IC50 of 0.53 μM). Contrary to the antimalaria activity of hybrids 4-8 against Plasmodium falciparum 3D7 strain with slightly higher IC50 values (between 7.2 and 30.2 nM) than that of their parent compound DHA, hybrids 5-7 possessed very promising activity (IC50 values lower than 0.5 μM) against human cytomegalovirus (HCMV). The application of 1,2,4-trioxane-ferrocene hybrids against HCMV is unprecedented and demonstrated here for the first time.
- Date of acceptance
- 2015
- Autoren
- Christoph Reiter
- Tony Fröhlich
- Maen Zeino
- Manfred Marschall
- Hanife Bahsi
- Maria Leidenberger
- Oliver Friedrich
- Barbara Kappes
- Frank Hampel
- Thomas Efferth
- Svetlana B Tsogoeva
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/25965779
- DOI
- 10.1016/j.ejmech.2015.04.053
- eISSN
- 1768-3254
- Zeitschrift
- Eur J Med Chem
- Schlüsselwörter
- Artemisinin
- Cancer
- Ferrocene
- Human cytomegalovirus
- Hybrid
- Malaria
- Artemisinins
- Cell Line, Tumor
- Drug Resistance, Multiple
- Ferrous Compounds
- Heterocyclic Compounds
- Heterocyclic Compounds, 4 or More Rings
- Humans
- Inhibitory Concentration 50
- Leukemia
- Metallocenes
- Plasmodium falciparum
- Sprache
- eng
- Country
- France
- Paginierung
- 164 - 172
- PII
- S0223-5234(15)30017-9
- Datum der Veröffentlichung
- 2015
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2016
- Titel
- New efficient artemisinin derived agents against human leukemia cells, human cytomegalovirus and Plasmodium falciparum: 2nd generation 1,2,4-trioxane-ferrocene hybrids.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 97
Data source: PubMed
- Beziehungen:
- Property of