Activity of the antiestrogenic cajanin stilbene acid towards breast cancer
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Yujie Fu
- Onat Kadioglu
- Benjamin Wiench
- Zuofu Wei
- Wei Wang
- Meng Luo
- Xiaohe Yang
- Chengbo Gu
- Yuangang Zu
- Thomas Efferth
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000364979600018&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1016/j.jnutbio.2015.06.004
- eISSN
- 1873-4847
- Externe Identifier
- Clarivate Analytics Document Solution ID: CW4RK
- PubMed Identifier: 26365581
- ISSN
- 0955-2863
- Ausgabe der Veröffentlichung
- 11
- Zeitschrift
- JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Schlüsselwörter
- Breast cancer
- Estrogen receptor
- Microarray
- Pharmacogenomics
- Tamoxifen resistance
- Xenograft tumor
- Paginierung
- 1273 - 1282
- Datum der Veröffentlichung
- 2015
- Status
- Published
- Titel
- Activity of the antiestrogenic cajanin stilbene acid towards breast cancer
- Sub types
- Article
- Ausgabe der Zeitschrift
- 26
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Yujie Fu
- Onat Kadioglu
- Benjamin Wiench
- Zuofu Wei
- Wei Wang
- Meng Luo
- Xiaohe Yang
- Chengbo Gu
- Yuangang Zu
- Thomas Efferth
- DOI
- 10.1016/j.jnutbio.2015.06.004
- ISSN
- 0955-2863
- Ausgabe der Veröffentlichung
- 11
- Zeitschrift
- The Journal of Nutritional Biochemistry
- Sprache
- en
- Paginierung
- 1273 - 1282
- Datum der Veröffentlichung
- 2015
- Status
- Published
- Herausgeber
- Elsevier BV
- Herausgeber URL
- http://dx.doi.org/10.1016/j.jnutbio.2015.06.004
- Datum der Datenerfassung
- 2022
- Titel
- Activity of the antiestrogenic cajanin stilbene acid towards breast cancer
- Ausgabe der Zeitschrift
- 26
Data source: Crossref
- Abstract
- Antiestrogenic therapy is a mainstay for estrogen receptor (ERα)-positive breast cancer. Due to the development of resistance to established antihormones such as tamoxifen, novel compounds are required. The low abundant cajanin stilbene acid (CSA) recently isolated by us from Pigeon Pea (Cajanus cajan) has structural similarities with estrogen. We analyzed the cytotoxic and anticancer activity of CSA in ERα-positive and -negative human breast cancer cells in vitro, in vivo and in silico. CSA exerts anticancer and antiestrogenic activities towards ERα-positive breast cancer, and it showed cytotoxicity towards tamoxifen-resistant MCF-7 cells, implying that CSA may be active against tamoxifen-resistant breast cancer cells. CSA showed low cytotoxicity in ERα-negative breast tumor cells as expected. Comparable cytotoxicity was observed towards p53 negative MCF-7 cells, implying that CSA is effective independent of the p53 status. Xenografted MCF-7 cells in nude mice were better inhibited by CSA than by cyclophosphamide. Testing of 8 primary cell cultures derived from human breast cancer biopsies showed that cell cultures from ER-positive tumors were more sensitive than from ER-negative ones. Dose-dependent decrease in ERα protein levels was observed upon CSA treatment. Synergistic effect with tamoxifen was observed in terms of increased p53 protein level. CSA affected pathways related to p53, cancer and cell proliferation. Gene promoter analyses supported the ERα regulation. CSA bound to the same site as 17β-estradiol and tamoxifen on ERα. In conclusion, CSA exerts its anticancer effects in ERα-positive breast cancer cells by binding and inhibiting ERα.
- Addresses
- Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, China; Engineering Research Center of Forest Bio-Preparation, Ministry of Education, Northeast Forestry University, Harbin, China.
- Autoren
- Yujie Fu
- Onat Kadioglu
- Benjamin Wiench
- Zuofu Wei
- Wei Wang
- Meng Luo
- Xiaohe Yang
- Chengbo Gu
- Yuangang Zu
- Thomas Efferth
- Thomas Efferth
- DOI
- 10.1016/j.jnutbio.2015.06.004
- eISSN
- 1873-4847
- Externe Identifier
- PubMed Identifier: 26365581
- Open access
- false
- ISSN
- 0955-2863
- Ausgabe der Veröffentlichung
- 11
- Zeitschrift
- The Journal of nutritional biochemistry
- Schlüsselwörter
- Cell Line, Tumor
- Animals
- Humans
- Mice, Nude
- Breast Neoplasms
- Salicylates
- Stilbenes
- Tamoxifen
- Estrogen Antagonists
- Receptors, Estrogen
- Estrogen Receptor alpha
- Antineoplastic Combined Chemotherapy Protocols
- Xenograft Model Antitumor Assays
- Gene Expression Regulation, Neoplastic
- Adult
- Middle Aged
- Female
- Promoter Regions, Genetic
- MCF-7 Cells
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2015
- Paginierung
- 1273 - 1282
- Datum der Veröffentlichung
- 2015
- Status
- Published
- Datum der Datenerfassung
- 2015
- Titel
- Activity of the antiestrogenic cajanin stilbene acid towards breast cancer.
- Sub types
- Research Support, Non-U.S. Gov't
- Journal Article
- Ausgabe der Zeitschrift
- 26
Data source: Europe PubMed Central
- Abstract
- Antiestrogenic therapy is a mainstay for estrogen receptor (ERα)-positive breast cancer. Due to the development of resistance to established antihormones such as tamoxifen, novel compounds are required. The low abundant cajanin stilbene acid (CSA) recently isolated by us from Pigeon Pea (Cajanus cajan) has structural similarities with estrogen. We analyzed the cytotoxic and anticancer activity of CSA in ERα-positive and -negative human breast cancer cells in vitro, in vivo and in silico. CSA exerts anticancer and antiestrogenic activities towards ERα-positive breast cancer, and it showed cytotoxicity towards tamoxifen-resistant MCF-7 cells, implying that CSA may be active against tamoxifen-resistant breast cancer cells. CSA showed low cytotoxicity in ERα-negative breast tumor cells as expected. Comparable cytotoxicity was observed towards p53 negative MCF-7 cells, implying that CSA is effective independent of the p53 status. Xenografted MCF-7 cells in nude mice were better inhibited by CSA than by cyclophosphamide. Testing of 8 primary cell cultures derived from human breast cancer biopsies showed that cell cultures from ER-positive tumors were more sensitive than from ER-negative ones. Dose-dependent decrease in ERα protein levels was observed upon CSA treatment. Synergistic effect with tamoxifen was observed in terms of increased p53 protein level. CSA affected pathways related to p53, cancer and cell proliferation. Gene promoter analyses supported the ERα regulation. CSA bound to the same site as 17β-estradiol and tamoxifen on ERα. In conclusion, CSA exerts its anticancer effects in ERα-positive breast cancer cells by binding and inhibiting ERα.
- Date of acceptance
- 2015
- Autoren
- Yujie Fu
- Onat Kadioglu
- Benjamin Wiench
- Zuofu Wei
- Wei Wang
- Meng Luo
- Xiaohe Yang
- Chengbo Gu
- Yuangang Zu
- Thomas Efferth
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/26365581
- DOI
- 10.1016/j.jnutbio.2015.06.004
- eISSN
- 1873-4847
- Ausgabe der Veröffentlichung
- 11
- Zeitschrift
- J Nutr Biochem
- Schlüsselwörter
- Breast cancer
- Estrogen receptor
- Microarray
- Pharmacogenomics
- Tamoxifen resistance
- Xenograft tumor
- Adult
- Animals
- Antineoplastic Combined Chemotherapy Protocols
- Breast Neoplasms
- Cell Line, Tumor
- Estrogen Antagonists
- Estrogen Receptor alpha
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- MCF-7 Cells
- Mice, Nude
- Middle Aged
- Promoter Regions, Genetic
- Receptors, Estrogen
- Salicylates
- Stilbenes
- Tamoxifen
- Xenograft Model Antitumor Assays
- Sprache
- eng
- Country
- United States
- Paginierung
- 1273 - 1282
- PII
- S0955-2863(15)00153-9
- Datum der Veröffentlichung
- 2015
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2017
- Titel
- Activity of the antiestrogenic cajanin stilbene acid towards breast cancer.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 26
Data source: PubMed
- Beziehungen:
- Property of