Hormesis: Decoding Two Sides of the Same Coin

Publication type:
Journal article
Metadata:
Autoren
  • Dipita Bhakta-Guha
  • Thomas Efferth
DOI
10.3390/ph8040865
eISSN
1424-8247
Ausgabe der Veröffentlichung
4
Zeitschrift
Pharmaceuticals
Sprache
en
Online publication date
2015
Paginierung
865 - 883
Status
Published online
Herausgeber
MDPI AG
Herausgeber URL
http://dx.doi.org/10.3390/ph8040865
Datum der Datenerfassung
2018
Titel
Hormesis: Decoding Two Sides of the Same Coin
Ausgabe der Zeitschrift
8

Data source: Crossref

Other metadata sources:
Abstract
In the paradigm of drug administration, determining the correct dosage of a therapeutic is often a challenge. Several drugs have been noted to demonstrate contradictory effects per se at high and low doses. This duality in function of a drug at different concentrations is known as hormesis. Therefore, it becomes necessary to study these biphasic functions in order to understand the mechanistic basis of their effects. In this article, we focus on different molecules and pathways associated with diseases that possess a duality in their function and thus prove to be the seat of hormesis. In particular, we have highlighted the pathways and factors involved in the progression of cancer and how the biphasic behavior of the molecules involved can alter the manifestations of cancer. Because of the pragmatic role that it exhibits, the imminent need is to draw attention to the concept of hormesis. Herein, we also discuss different stressors that trigger hormesis and how stress-mediated responses increase the overall adaptive response of an individual to stress stimulus. We talk about common pathways through which cancer progresses (such as nuclear factor erythroid 2-related factor 2-Kelch-like ECH-associated protein 1 (Nrf2-Keap1), sirtuin-forkhead box O (SIRT-FOXO) and others), analyzing how diverse molecules associated with these pathways conform to hormesis.
Addresses
  • School of Chemical and Biotechnology, SASTRA University, Thanjavur, Tamil Nadu 613401, India. dipita2001@gmail.com.
Autoren
DOI
10.3390/ph8040865
eISSN
1424-8247
Externe Identifier
  • PubMed Identifier: 26694419
  • PubMed Central ID: PMC4695814
Open access
true
ISSN
1424-8247
Ausgabe der Veröffentlichung
4
Zeitschrift
Pharmaceuticals (Basel, Switzerland)
Sprache
eng
Medium
Electronic
Online publication date
2015
Open access status
Open Access
Paginierung
865 - 883
Datum der Veröffentlichung
2015
Status
Published
Publisher licence
CC BY
Datum der Datenerfassung
2015
Titel
Hormesis: Decoding Two Sides of the Same Coin.
Sub types
  • review-article
  • Review
  • Journal Article
Ausgabe der Zeitschrift
8

Files

https://www.mdpi.com/1424-8247/8/4/865/pdf?version=1450274739 https://europepmc.org/articles/PMC4695814?pdf=render

Data source: Europe PubMed Central

Abstract
In the paradigm of drug administration, determining the correct dosage of a therapeutic is often a challenge. Several drugs have been noted to demonstrate contradictory effects per se at high and low doses. This duality in function of a drug at different concentrations is known as hormesis. Therefore, it becomes necessary to study these biphasic functions in order to understand the mechanistic basis of their effects. In this article, we focus on different molecules and pathways associated with diseases that possess a duality in their function and thus prove to be the seat of hormesis. In particular, we have highlighted the pathways and factors involved in the progression of cancer and how the biphasic behavior of the molecules involved can alter the manifestations of cancer. Because of the pragmatic role that it exhibits, the imminent need is to draw attention to the concept of hormesis. Herein, we also discuss different stressors that trigger hormesis and how stress-mediated responses increase the overall adaptive response of an individual to stress stimulus. We talk about common pathways through which cancer progresses (such as nuclear factor erythroid 2-related factor 2-Kelch-like ECH-associated protein 1 (Nrf2-Keap1), sirtuin-forkhead box O (SIRT-FOXO) and others), analyzing how diverse molecules associated with these pathways conform to hormesis.
Date of acceptance
2015
Autoren
  • Dipita Bhakta-Guha
  • Thomas Efferth
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/26694419
DOI
10.3390/ph8040865
Externe Identifier
  • PubMed Central ID: PMC4695814
ISSN
1424-8247
Ausgabe der Veröffentlichung
4
Zeitschrift
Pharmaceuticals (Basel)
Schlüsselwörter
  • biphasic
  • cancer
  • hormesis
  • mimetics
  • pathways
  • stressor
Sprache
eng
Country
Switzerland
Paginierung
865 - 883
PII
ph8040865
Datum der Veröffentlichung
2015
Status
Published online
Datum, an dem der Datensatz öffentlich gemacht wurde
2015
Titel
Hormesis: Decoding Two Sides of the Same Coin.
Sub types
  • Journal Article
  • Review
Ausgabe der Zeitschrift
8

Data source: PubMed

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