Cytotoxicity of an unprecedented brominated oleanolide and a new furoceramide from the Cameroonian spice, Echinops giganteus
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Louis P Sandjo
- Victor Kuete
- Xavier N Siwe
- Herve MP Poumale
- Thomas Efferth
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000387296300004&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1080/14786419.2015.1120724
- eISSN
- 1478-6427
- Externe Identifier
- Clarivate Analytics Document Solution ID: EB3VH
- PubMed Identifier: 26733224
- ISSN
- 1478-6419
- Ausgabe der Veröffentlichung
- 22
- Zeitschrift
- NATURAL PRODUCT RESEARCH
- Schlüsselwörter
- Asteraceae
- Echinops giganteus
- brominated triterpene
- furoceramide
- cytotoxicity
- Paginierung
- 2529 - 2537
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Titel
- Cytotoxicity of an unprecedented brominated oleanolide and a new furoceramide from the Cameroonian spice, <i>Echinops giganteus</i>
- Sub types
- Article
- Ausgabe der Zeitschrift
- 30
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Louis P Sandjo
- Victor Kuete
- Xavier N Siwe
- Herve MP Poumale
- Thomas Efferth
- DOI
- 10.1080/14786419.2015.1120724
- eISSN
- 1478-6427
- ISSN
- 1478-6419
- Ausgabe der Veröffentlichung
- 22
- Zeitschrift
- Natural Product Research
- Sprache
- en
- Online publication date
- 2016
- Paginierung
- 2529 - 2537
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Herausgeber
- Informa UK Limited
- Herausgeber URL
- http://dx.doi.org/10.1080/14786419.2015.1120724
- Datum der Datenerfassung
- 2020
- Titel
- Cytotoxicity of an unprecedented brominated oleanolide and a new furoceramide from the Cameroonian spice, <i>Echinops giganteus</i>
- Ausgabe der Zeitschrift
- 30
Data source: Crossref
- Abstract
- A preliminary study on Echinops giganteus (Asteraceae) showed that the methanolic extract has interesting cytotoxicities against a panel of cancer cell lines. From this extract, a lignan, a flavonoid and a polyacetylenic thiophene identified were three times less cytotoxic than the extract. In the search of the metabolites responsible for the bioactivity, a new harvested E. giganteus was subjected to a phytochemical study using chromatographic methods. In the course of the work, two new compounds: a brominated oleanolide (1) and a tetrahydrofurano-ceramide (2) were obtained along with β-amyrin acetate (3), 2-(penta-1,3-diynyl)-5-(4-hydroxybut-1-ynyl)-thiophene (4), 2-(penta-1,3-diynyl)-5-(3,4-dihydroxybut-1-ynyl)-thiophene (5) and 4-hydroxy-2,6-di-(3',4'-dimethoxyphenyl)-3,7-dioxabicyclo-(3.3.0)octane (6). Their structures were determined on the basis of NMR spectroscopy and mass spectrometry data in conjunction with those reported in the literature. The cytotoxicity of 1, 2 and 5 was evaluated by employing resazurin assay against a panel of cancer cell lines with IC<sub>50</sub> values in range 6.12 ± 0.46-46.96 ± 3.61 μM.
- Addresses
- a Department of Pharmaceutical Sciences , CCS - Universidade Federal de Santa Catarina , Trindade , Brazil.
- Autoren
- Louis P Sandjo
- Victor Kuete
- Xavier N Siwe
- Herve MP Poumale
- Thomas Efferth
- Thomas Efferth
- DOI
- 10.1080/14786419.2015.1120724
- eISSN
- 1478-6427
- Externe Identifier
- PubMed Identifier: 26733224
- Open access
- false
- ISSN
- 1478-6419
- Ausgabe der Veröffentlichung
- 22
- Zeitschrift
- Natural product research
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2016
- Paginierung
- 2529 - 2537
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Datum der Datenerfassung
- 2016
- Titel
- Cytotoxicity of an unprecedented brominated oleanolide and a new furoceramide from the Cameroonian spice, Echinops giganteus.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 30
Data source: Europe PubMed Central
- Abstract
- A preliminary study on Echinops giganteus (Asteraceae) showed that the methanolic extract has interesting cytotoxicities against a panel of cancer cell lines. From this extract, a lignan, a flavonoid and a polyacetylenic thiophene identified were three times less cytotoxic than the extract. In the search of the metabolites responsible for the bioactivity, a new harvested E. giganteus was subjected to a phytochemical study using chromatographic methods. In the course of the work, two new compounds: a brominated oleanolide (1) and a tetrahydrofurano-ceramide (2) were obtained along with β-amyrin acetate (3), 2-(penta-1,3-diynyl)-5-(4-hydroxybut-1-ynyl)-thiophene (4), 2-(penta-1,3-diynyl)-5-(3,4-dihydroxybut-1-ynyl)-thiophene (5) and 4-hydroxy-2,6-di-(3',4'-dimethoxyphenyl)-3,7-dioxabicyclo-(3.3.0)octane (6). Their structures were determined on the basis of NMR spectroscopy and mass spectrometry data in conjunction with those reported in the literature. The cytotoxicity of 1, 2 and 5 was evaluated by employing resazurin assay against a panel of cancer cell lines with IC50 values in range 6.12 ± 0.46-46.96 ± 3.61 μM.
- Autoren
- Louis P Sandjo
- Victor Kuete
- Xavier N Siwe
- Herve MP Poumale
- Thomas Efferth
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/26733224
- DOI
- 10.1080/14786419.2015.1120724
- eISSN
- 1478-6427
- Ausgabe der Veröffentlichung
- 22
- Zeitschrift
- Nat Prod Res
- Schlüsselwörter
- Asteraceae
- Echinops giganteus
- brominated triterpene
- cytotoxicity
- furoceramide
- Sprache
- eng
- Country
- England
- Paginierung
- 2529 - 2537
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Titel
- Cytotoxicity of an unprecedented brominated oleanolide and a new furoceramide from the Cameroonian spice, Echinops giganteus.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 30
Data source: PubMed
- Beziehungen:
- Property of