Peptide aptamer identified by molecular docking targeting translationally controlled tumor protein in leukemia cells

Publication type:
Journal article
Metadata:
Autoren
  • Onat Kadioglu
  • Thomas Efferth
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000379015000014&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1007/s10637-016-0339-6
eISSN
1573-0646
Externe Identifier
  • Clarivate Analytics Document Solution ID: DQ2EP
  • PubMed Identifier: 26972431
ISSN
0167-6997
Ausgabe der Veröffentlichung
4
Zeitschrift
INVESTIGATIONAL NEW DRUGS
Schlüsselwörter
  • Cancer
  • Fortilin
  • Histamine releasing factor
  • Leukemia
  • Molecular docking
  • Peptide aptamer
  • TCTP
Paginierung
515 - 521
Datum der Veröffentlichung
2016
Status
Published
Titel
Peptide aptamer identified by molecular docking targeting translationally controlled tumor protein in leukemia cells
Sub types
  • Article
Ausgabe der Zeitschrift
34

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Onat Kadioglu
  • Thomas Efferth
DOI
10.1007/s10637-016-0339-6
eISSN
1573-0646
ISSN
0167-6997
Ausgabe der Veröffentlichung
4
Zeitschrift
Investigational New Drugs
Sprache
en
Online publication date
2016
Paginierung
515 - 521
Datum der Veröffentlichung
2016
Status
Published
Herausgeber
Springer Science and Business Media LLC
Herausgeber URL
http://dx.doi.org/10.1007/s10637-016-0339-6
Datum der Datenerfassung
2023
Titel
Peptide aptamer identified by molecular docking targeting translationally controlled tumor protein in leukemia cells
Ausgabe der Zeitschrift
34

Data source: Crossref

Abstract
Bioinformatics screening and molecular docking analyses were utilized to select high affinity peptides targeting translationally controlled tumor protein (TCTP). Selected peptide aptamers were tested towards cancer cell lines with different levels of TCTP expression. One peptide (WGQWPYHC) revealed specific cytotoxicity according to the TCTP expression in tumor cells without affecting normal cells. Western blot analysis showed peptide-induced down-regulation of TCTP as primary target as well as of cell-cycle related downstream proteins (CDK2, CDK6, Cyclin D3) in MOLT-4 leukemia cells. "WGQWPYHC" deserves further analysis for targeted therapy of TCTP-expressing tumor cells. Graphical abstract Molecular docking on TCTP, cytotoxicity toward MOLT-4 leukemia cell line and downregulation of CDK2, CDK6, CyclinD3 and TCTP proteins.
Addresses
  • Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Staudinger Weg 5, 55128, Mainz, Germany.
Autoren
DOI
10.1007/s10637-016-0339-6
eISSN
1573-0646
Externe Identifier
  • PubMed Identifier: 26972431
Open access
false
ISSN
0167-6997
Ausgabe der Veröffentlichung
4
Zeitschrift
Investigational new drugs
Schlüsselwörter
  • Cell Line, Tumor
  • Humans
  • Leukemia
  • RNA, Small Interfering
  • Antineoplastic Agents
  • Cell Survival
  • Aptamers, Peptide
  • Molecular Docking Simulation
  • Biomarkers, Tumor
  • Tumor Protein, Translationally-Controlled 1
Sprache
eng
Medium
Print-Electronic
Online publication date
2016
Paginierung
515 - 521
Datum der Veröffentlichung
2016
Status
Published
Datum der Datenerfassung
2016
Titel
Peptide aptamer identified by molecular docking targeting translationally controlled tumor protein in leukemia cells.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
34

Data source: Europe PubMed Central

Abstract
Bioinformatics screening and molecular docking analyses were utilized to select high affinity peptides targeting translationally controlled tumor protein (TCTP). Selected peptide aptamers were tested towards cancer cell lines with different levels of TCTP expression. One peptide (WGQWPYHC) revealed specific cytotoxicity according to the TCTP expression in tumor cells without affecting normal cells. Western blot analysis showed peptide-induced down-regulation of TCTP as primary target as well as of cell-cycle related downstream proteins (CDK2, CDK6, Cyclin D3) in MOLT-4 leukemia cells. "WGQWPYHC" deserves further analysis for targeted therapy of TCTP-expressing tumor cells. Graphical abstract Molecular docking on TCTP, cytotoxicity toward MOLT-4 leukemia cell line and downregulation of CDK2, CDK6, CyclinD3 and TCTP proteins.
Date of acceptance
2016
Autoren
  • Onat Kadioglu
  • Thomas Efferth
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/26972431
DOI
10.1007/s10637-016-0339-6
eISSN
1573-0646
Ausgabe der Veröffentlichung
4
Zeitschrift
Invest New Drugs
Schlüsselwörter
  • Cancer
  • Fortilin
  • Histamine releasing factor
  • Leukemia
  • Molecular docking
  • Peptide aptamer
  • TCTP
  • Antineoplastic Agents
  • Aptamers, Peptide
  • Biomarkers, Tumor
  • Cell Line, Tumor
  • Cell Survival
  • Humans
  • Leukemia
  • Molecular Docking Simulation
  • RNA, Small Interfering
  • Tumor Protein, Translationally-Controlled 1
Sprache
eng
Country
United States
Paginierung
515 - 521
PII
10.1007/s10637-016-0339-6
Datum der Veröffentlichung
2016
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2017
Titel
Peptide aptamer identified by molecular docking targeting translationally controlled tumor protein in leukemia cells.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
34

Data source: PubMed

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