Immunogenicity of mammary tumor cells can be induced by shikonin via direct binding-interference with hnRNPA1
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Shu-Yi Yin
- Thomas Efferth
- Feng-Yin Jian
- Yung-Hsiang Chen
- Chia-I Liu
- Andrew HJ Wang
- Yet-Ran Chen
- Pei-Wen Hsiao
- Ning-Sun Yang
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000385395700059&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.18632/oncotarget.9660
- eISSN
- 1949-2553
- Externe Identifier
- Clarivate Analytics Document Solution ID: DY8QU
- PubMed Identifier: 27248319
- Ausgabe der Veröffentlichung
- 28
- Zeitschrift
- ONCOTARGET
- Schlüsselwörter
- shikonin
- heterogeneous nuclear ribonucleoprotein A1
- tumor immunogenicity
- immunogenic cell death
- Paginierung
- 43629 - 43653
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Titel
- Immunogenicity of mammary tumor cells can be induced by shikonin via direct binding-interference with hnRNPA1
- Sub types
- Article
- Ausgabe der Zeitschrift
- 7
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Shu-Yi Yin
- Thomas Efferth
- Feng-Yin Jian
- Yung-Hsiang Chen
- Chia-I Liu
- Andrew HJ Wang
- Yet-Ran Chen
- Pei-Wen Hsiao
- Ning-Sun Yang
- DOI
- 10.18632/oncotarget.9660
- eISSN
- 1949-2553
- Ausgabe der Veröffentlichung
- 28
- Zeitschrift
- Oncotarget
- Sprache
- en
- Online publication date
- 2016
- Paginierung
- 43629 - 43653
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Herausgeber
- Impact Journals, LLC
- Herausgeber URL
- http://dx.doi.org/10.18632/oncotarget.9660
- Datum der Datenerfassung
- 2020
- Titel
- Immunogenicity of mammary tumor cells can be induced by shikonin via direct binding-interference with hnRNPA1
- Ausgabe der Zeitschrift
- 7
Data source: Crossref
- Abstract
- Immunogenic cell death (ICD) of tumor cells occurs via various pathways that activate immune cell systems against cancer. Previous studies have demonstrated that shikonin (SK), a plant secondary metabolite, can confer strong pharmacological activities that activate ICD and strong immunogenicity of tumor cells. However, the exact hierarchical regulatory mechanisms including the molecular targets of SK-activated immunogenicity are still unknown. Here, the heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) was revealed to serve as a specific protein target for SK. This binding plays a key role in SK-stimulated ICD activity and the suppression of post-transcriptional mRNA processing, including nuclear export activity of newly synthesized mRNAs in mammary carcinoma cells in vitro. Moreover, it also mechanistically mediates the anti-metastatic effect of a tumor cell lysate (TCL) vaccine, which can be readily generated from SK-treated 4T1 tumor cells (SK-TCL), and the derived tumor-immunogenicity of SK-TCL-treated dendritic cells in vivo. Together, the identification of hnRNPA1 as the intracellular molecular target provides compelling pharmacology-based knowledge for the potential clinical use of SK-induced immunogenicity. In addition, SK may also serve as a potent suppressor that interferes with specific post-transcriptional activities, a mechanism which may be useful for exploitation in cancer therapeutics.
- Addresses
- Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan, ROC.
- Autoren
- Shu-Yi Yin
- Thomas Efferth
- Thomas Efferth
- Feng-Yin Jian
- Yung-Hsiang Chen
- Chia-I Liu
- Andrew HJ Wang
- Yet-Ran Chen
- Pei-Wen Hsiao
- Ning-Sun Yang
- DOI
- 10.18632/oncotarget.9660
- eISSN
- 1949-2553
- Externe Identifier
- PubMed Identifier: 27248319
- PubMed Central ID: PMC5190049
- Open access
- true
- ISSN
- 1949-2553
- Ausgabe der Veröffentlichung
- 28
- Zeitschrift
- Oncotarget
- Schlüsselwörter
- Dendritic Cells
- Cell Line, Tumor
- Animals
- Mice, Inbred BALB C
- Humans
- Mice
- Breast Neoplasms
- Naphthoquinones
- RNA, Messenger
- Antineoplastic Agents
- Cancer Vaccines
- Xenograft Model Antitumor Assays
- Apoptosis
- RNA Processing, Post-Transcriptional
- Female
- Tandem Mass Spectrometry
- Molecular Docking Simulation
- Heterogeneous Nuclear Ribonucleoprotein A1
- Sprache
- eng
- Medium
- Open access status
- Open Access
- Paginierung
- 43629 - 43653
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2016
- Titel
- Immunogenicity of mammary tumor cells can be induced by shikonin via direct binding-interference with hnRNPA1.
- Sub types
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 7
Files
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=9660&path%5B%5D=41669 https://europepmc.org/articles/PMC5190049?pdf=render
Data source: Europe PubMed Central
- Abstract
- Immunogenic cell death (ICD) of tumor cells occurs via various pathways that activate immune cell systems against cancer. Previous studies have demonstrated that shikonin (SK), a plant secondary metabolite, can confer strong pharmacological activities that activate ICD and strong immunogenicity of tumor cells. However, the exact hierarchical regulatory mechanisms including the molecular targets of SK-activated immunogenicity are still unknown. Here, the heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) was revealed to serve as a specific protein target for SK. This binding plays a key role in SK-stimulated ICD activity and the suppression of post-transcriptional mRNA processing, including nuclear export activity of newly synthesized mRNAs in mammary carcinoma cells in vitro. Moreover, it also mechanistically mediates the anti-metastatic effect of a tumor cell lysate (TCL) vaccine, which can be readily generated from SK-treated 4T1 tumor cells (SK-TCL), and the derived tumor-immunogenicity of SK-TCL-treated dendritic cells in vivo. Together, the identification of hnRNPA1 as the intracellular molecular target provides compelling pharmacology-based knowledge for the potential clinical use of SK-induced immunogenicity. In addition, SK may also serve as a potent suppressor that interferes with specific post-transcriptional activities, a mechanism which may be useful for exploitation in cancer therapeutics.
- Date of acceptance
- 2016
- Autoren
- Shu-Yi Yin
- Thomas Efferth
- Feng-Yin Jian
- Yung-Hsiang Chen
- Chia-I Liu
- Andrew HJ Wang
- Yet-Ran Chen
- Pei-Wen Hsiao
- Ning-Sun Yang
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/27248319
- DOI
- 10.18632/oncotarget.9660
- eISSN
- 1949-2553
- Externe Identifier
- PubMed Central ID: PMC5190049
- Ausgabe der Veröffentlichung
- 28
- Zeitschrift
- Oncotarget
- Schlüsselwörter
- heterogeneous nuclear ribonucleoprotein A1
- immunogenic cell death
- shikonin
- tumor immunogenicity
- Animals
- Antineoplastic Agents
- Apoptosis
- Breast Neoplasms
- Cancer Vaccines
- Cell Line, Tumor
- Dendritic Cells
- Female
- Heterogeneous Nuclear Ribonucleoprotein A1
- Humans
- Mice
- Mice, Inbred BALB C
- Molecular Docking Simulation
- Naphthoquinones
- RNA Processing, Post-Transcriptional
- RNA, Messenger
- Tandem Mass Spectrometry
- Xenograft Model Antitumor Assays
- Sprache
- eng
- Country
- United States
- Paginierung
- 43629 - 43653
- PII
- 9660
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2017
- Titel
- Immunogenicity of mammary tumor cells can be induced by shikonin via direct binding-interference with hnRNPA1.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 7
Data source: PubMed
- Beziehungen:
- Property of