Cytotoxicity of Salvia miltiorrhiza Against Multidrug-Resistant Cancer Cells

Publication type:
Journal article
Metadata:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000378943500012&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1142/S0192415X16500488
eISSN
1793-6853
Externe Identifier
  • Clarivate Analytics Document Solution ID: DQ1EF
  • PubMed Identifier: 27222067
ISSN
0192-415X
Ausgabe der Veröffentlichung
4
Zeitschrift
AMERICAN JOURNAL OF CHINESE MEDICINE
Schlüsselwörter
  • Cancer
  • Chemotherapy
  • Lamiaceae
  • Multidrug Resistance
  • Pharmacogenomics
Paginierung
871 - 894
Datum der Veröffentlichung
2016
Status
Published
Titel
Cytotoxicity of <i>Salvia miltiorrhiza</i> Against Multidrug-Resistant Cancer Cells
Sub types
  • Article
Ausgabe der Zeitschrift
44

Data source: Web of Science (Lite)

Other metadata sources:
Abstract
<jats:p>Salvia miltiorrhiza Bunge (Lamiaceae) is a well-known Chinese herb that possesses numerous therapeutic activities, including anticancer effects. In this study, the cytotoxicity and the biological mechanisms of S. miltiorrhiza (SM) root extract on diverse resistant and sensitive cancer cell lines were investigated. CEM/ADR5000 cells were 1.68-fold resistant to CCRF-CEM cells, while HCT116 (p53[Formula: see text] and U87.MG[Formula: see text]EGFR cells were hypersensitive (collateral sensitive) compared to their parental cells. SM root extract stimulated ROS generation, cell cycle S phase arrest and apoptosis. The induction of the intrinsic apoptotic pathway was validated by increased cleavage of caspase 3, 7, 9 and poly ADP-ribose polymerase (PARP). MAP kinases including JNK, ERK1/2 and p38 were obviously phosphorylated and nuclear P65 was downregulated upon SM treatment. Transcriptome-wide COMPARE analysis revealed that the expression of encoding genes with diverse functions were associated with the cellular response to cryptotanshinone, one of the main constituents of SM root extract. In conclusion, SM root extract exerted profound cytotoxicity towards various sensitive and resistant cancer cells and induced the intrinsic apoptotic pathway.</jats:p>
Autoren
DOI
10.1142/s0192415x16500488
eISSN
1793-6853
ISSN
0192-415X
Ausgabe der Veröffentlichung
04
Zeitschrift
The American Journal of Chinese Medicine
Sprache
en
Online publication date
2016
Paginierung
871 - 894
Datum der Veröffentlichung
2016
Status
Published
Herausgeber
World Scientific Pub Co Pte Ltd
Herausgeber URL
http://dx.doi.org/10.1142/s0192415x16500488
Datum der Datenerfassung
2022
Titel
Cytotoxicity of<i>Salvia miltiorrhiza</i>Against Multidrug-Resistant Cancer Cells
Ausgabe der Zeitschrift
44

Data source: Crossref

Abstract
Salvia miltiorrhiza Bunge (Lamiaceae) is a well-known Chinese herb that possesses numerous therapeutic activities, including anticancer effects. In this study, the cytotoxicity and the biological mechanisms of S. miltiorrhiza (SM) root extract on diverse resistant and sensitive cancer cell lines were investigated. CEM/ADR5000 cells were 1.68-fold resistant to CCRF-CEM cells, while HCT116 (p53[Formula: see text] and U87.MG[Formula: see text]EGFR cells were hypersensitive (collateral sensitive) compared to their parental cells. SM root extract stimulated ROS generation, cell cycle S phase arrest and apoptosis. The induction of the intrinsic apoptotic pathway was validated by increased cleavage of caspase 3, 7, 9 and poly ADP-ribose polymerase (PARP). MAP kinases including JNK, ERK1/2 and p38 were obviously phosphorylated and nuclear P65 was downregulated upon SM treatment. Transcriptome-wide COMPARE analysis revealed that the expression of encoding genes with diverse functions were associated with the cellular response to cryptotanshinone, one of the main constituents of SM root extract. In conclusion, SM root extract exerted profound cytotoxicity towards various sensitive and resistant cancer cells and induced the intrinsic apoptotic pathway.
Addresses
  • * Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany.
Autoren
DOI
10.1142/s0192415x16500488
eISSN
1793-6853
Externe Identifier
  • PubMed Identifier: 27222067
Open access
false
ISSN
0192-415X
Ausgabe der Veröffentlichung
4
Zeitschrift
The American journal of Chinese medicine
Schlüsselwörter
  • Cell Line, Tumor
  • Humans
  • Salvia miltiorrhiza
  • Neoplasms
  • Reactive Oxygen Species
  • Caspases
  • Drugs, Chinese Herbal
  • Antineoplastic Agents, Phytogenic
  • Apoptosis
  • Drug Resistance, Neoplasm
  • Cell Cycle Checkpoints
Sprache
eng
Medium
Print-Electronic
Online publication date
2016
Paginierung
871 - 894
Datum der Veröffentlichung
2016
Status
Published
Datum der Datenerfassung
2016
Titel
Cytotoxicity of Salvia miltiorrhiza Against Multidrug-Resistant Cancer Cells.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
44

Data source: Europe PubMed Central

Abstract
Salvia miltiorrhiza Bunge (Lamiaceae) is a well-known Chinese herb that possesses numerous therapeutic activities, including anticancer effects. In this study, the cytotoxicity and the biological mechanisms of S. miltiorrhiza (SM) root extract on diverse resistant and sensitive cancer cell lines were investigated. CEM/ADR5000 cells were 1.68-fold resistant to CCRF-CEM cells, while HCT116 (p53[Formula: see text] and U87.MG[Formula: see text]EGFR cells were hypersensitive (collateral sensitive) compared to their parental cells. SM root extract stimulated ROS generation, cell cycle S phase arrest and apoptosis. The induction of the intrinsic apoptotic pathway was validated by increased cleavage of caspase 3, 7, 9 and poly ADP-ribose polymerase (PARP). MAP kinases including JNK, ERK1/2 and p38 were obviously phosphorylated and nuclear P65 was downregulated upon SM treatment. Transcriptome-wide COMPARE analysis revealed that the expression of encoding genes with diverse functions were associated with the cellular response to cryptotanshinone, one of the main constituents of SM root extract. In conclusion, SM root extract exerted profound cytotoxicity towards various sensitive and resistant cancer cells and induced the intrinsic apoptotic pathway.
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/27222067
DOI
10.1142/S0192415X16500488
eISSN
1793-6853
Ausgabe der Veröffentlichung
4
Zeitschrift
Am J Chin Med
Schlüsselwörter
  • Cancer
  • Chemotherapy
  • Lamiaceae
  • Multidrug Resistance
  • Pharmacogenomics
  • Antineoplastic Agents, Phytogenic
  • Apoptosis
  • Caspases
  • Cell Cycle Checkpoints
  • Cell Line, Tumor
  • Drug Resistance, Neoplasm
  • Drugs, Chinese Herbal
  • Humans
  • Neoplasms
  • Reactive Oxygen Species
  • Salvia miltiorrhiza
Sprache
eng
Country
Singapore
Paginierung
871 - 894
Datum der Veröffentlichung
2016
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2017
Titel
Cytotoxicity of Salvia miltiorrhiza Against Multidrug-Resistant Cancer Cells.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
44

Data source: PubMed

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