Fatal Liver and Bone Marrow Toxicity by Combination Treatment of Dichloroacetate and Artesunate in a Glioblastoma Multiforme Patient: Case Report and Review of the Literature
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Martin Uhl
- Stefan Schwab
- Thomas Efferth
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000385051800001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.3389/fonc.2016.00204
- Externe Identifier
- Clarivate Analytics Document Solution ID: DY4EM
- PubMed Identifier: 27774434
- ISSN
- 2234-943X
- Zeitschrift
- FRONTIERS IN ONCOLOGY
- Schlüsselwörter
- adverse side effects
- cancer
- chemotherapy
- toxicology
- Artikelnummer
- ARTN 204
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Titel
- Fatal Liver and Bone Marrow Toxicity by Combination Treatment of Dichloroacetate and Artesunate in a Glioblastoma Multiforme Patient: Case Report and Review of the Literature
- Sub types
- Article
- Ausgabe der Zeitschrift
- 6
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Martin Uhl
- Stefan Schwab
- Thomas Efferth
- DOI
- 10.3389/fonc.2016.00204
- eISSN
- 2234-943X
- Zeitschrift
- Frontiers in Oncology
- Online publication date
- 2016
- Status
- Published online
- Herausgeber
- Frontiers Media SA
- Herausgeber URL
- http://dx.doi.org/10.3389/fonc.2016.00204
- Datum der Datenerfassung
- 2016
- Titel
- Fatal Liver and Bone Marrow Toxicity by Combination Treatment of Dichloroacetate and Artesunate in a Glioblastoma Multiforme Patient: Case Report and Review of the Literature
- Ausgabe der Zeitschrift
- 6
Data source: Crossref
- Abstract
- A 52-year-old male patient was treated with standard radiochemotherapy with temozolomide for glioblastoma multiforme (GBM). After worsening of his clinical condition, further tumor-specific treatment was unlikely to be successful, and the patient seeked help from an alternative practitioner, who administered a combination of dichloroacetate (DCA) and artesunate (ART). A few days later, the patient showed clinical and laboratory signs of liver damage and bone marrow toxicity (leukopenia, thrombocytopenia). Despite successful restoration of laboratory parameters upon symptomatic treatment, the patient died 10 days after the infusion. DCA bears a well-documented hepatotoxic risk, while ART can be considered as safe concerning hepatotoxicity. Bone marrow toxicity can appear upon ART application as reduced reticulocyte counts and disturbed erythropoiesis. It can be assumed that the simultaneous use of both drugs caused liver injury and bone marrow toxicity. The compassionate use of DCA/ART combination therapy outside of clinical trials cannot be recommended for GBM treatment.
- Addresses
- Department of Neurology, University of Erlangen-Nuremberg , Erlangen , Germany.
- Autoren
- Martin Uhl
- Stefan Schwab
- Thomas Efferth
- Thomas Efferth
- DOI
- 10.3389/fonc.2016.00204
- eISSN
- 2234-943X
- Externe Identifier
- PubMed Identifier: 27774434
- PubMed Central ID: PMC5053977
- Open access
- true
- ISSN
- 2234-943X
- Zeitschrift
- Frontiers in oncology
- Sprache
- eng
- Medium
- Electronic-eCollection
- Online publication date
- 2016
- Open access status
- Open Access
- Paginierung
- 204
- Datum der Veröffentlichung
- 2016
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2016
- Titel
- Fatal Liver and Bone Marrow Toxicity by Combination Treatment of Dichloroacetate and Artesunate in a Glioblastoma Multiforme Patient: Case Report and Review of the Literature.
- Sub types
- Case Reports
- case-report
- Ausgabe der Zeitschrift
- 6
Files
https://www.frontiersin.org/articles/10.3389/fonc.2016.00204/pdf https://europepmc.org/articles/PMC5053977?pdf=render
Data source: Europe PubMed Central
- Abstract
- A 52-year-old male patient was treated with standard radiochemotherapy with temozolomide for glioblastoma multiforme (GBM). After worsening of his clinical condition, further tumor-specific treatment was unlikely to be successful, and the patient seeked help from an alternative practitioner, who administered a combination of dichloroacetate (DCA) and artesunate (ART). A few days later, the patient showed clinical and laboratory signs of liver damage and bone marrow toxicity (leukopenia, thrombocytopenia). Despite successful restoration of laboratory parameters upon symptomatic treatment, the patient died 10 days after the infusion. DCA bears a well-documented hepatotoxic risk, while ART can be considered as safe concerning hepatotoxicity. Bone marrow toxicity can appear upon ART application as reduced reticulocyte counts and disturbed erythropoiesis. It can be assumed that the simultaneous use of both drugs caused liver injury and bone marrow toxicity. The compassionate use of DCA/ART combination therapy outside of clinical trials cannot be recommended for GBM treatment.
- Date of acceptance
- 2016
- Autoren
- Martin Uhl
- Stefan Schwab
- Thomas Efferth
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/27774434
- DOI
- 10.3389/fonc.2016.00204
- Externe Identifier
- PubMed Central ID: PMC5053977
- ISSN
- 2234-943X
- Zeitschrift
- Front Oncol
- Schlüsselwörter
- adverse side effects
- cancer
- chemotherapy
- toxicology
- Sprache
- eng
- Country
- Switzerland
- Paginierung
- 204
- Datum der Veröffentlichung
- 2016
- Status
- Published online
- Titel
- Fatal Liver and Bone Marrow Toxicity by Combination Treatment of Dichloroacetate and Artesunate in a Glioblastoma Multiforme Patient: Case Report and Review of the Literature.
- Sub types
- Case Reports
- Ausgabe der Zeitschrift
- 6
Data source: PubMed
- Beziehungen:
- Property of