Pharmacogenetics and Pharmacotherapy of Military Personnel Suffering from Post-traumatic Stress Disorder

Publication type:
Journal article
Metadata:
Autoren
  • Janine Nass
  • Thomas Efferth
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000407196400004&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.2174/1570159X15666161111113514
eISSN
1875-6190
Externe Identifier
  • Clarivate Analytics Document Solution ID: FC9YG
  • PubMed Identifier: 27834145
ISSN
1570-159X
Ausgabe der Veröffentlichung
6
Zeitschrift
CURRENT NEUROPHARMACOLOGY
Schlüsselwörter
  • DNA
  • genetics
  • mental diseases
  • pharmacology
  • single nucleotide polymorphisms
  • gene-environment interactions
Paginierung
831 - 860
Datum der Veröffentlichung
2017
Status
Published
Titel
Pharmacogenetics and Pharmacotherapy of Military Personnel Suffering from Post-traumatic Stress Disorder
Sub types
  • Review
Ausgabe der Zeitschrift
15

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Janine Naß
  • Thomas Efferth
DOI
10.2174/1570159x15666161111113514
ISSN
1570-159X
Ausgabe der Veröffentlichung
6
Zeitschrift
Current Neuropharmacology
Sprache
en
Datum der Veröffentlichung
2017
Status
Published
Herausgeber
Bentham Science Publishers Ltd.
Herausgeber URL
http://dx.doi.org/10.2174/1570159x15666161111113514
Datum der Datenerfassung
2017
Titel
Pharmacogenetics and Pharmacotherapy of Military Personnel Suffering from Post-traumatic Stress Disorder
Ausgabe der Zeitschrift
15

Data source: Crossref

Abstract
<h4>Background</h4>Posttraumatic stress disorder (PTSD) is a severe problem among soldiers with combating experience difficult to treat. The pathogenesis is still not fully understood at the psychological level. Therefore, genetic research became a focus of interest. The identification of single nucleotide polymorphisms (SNPs) may help to predict, which persons are at high risk to develop PTSD as a starting point to develop novel targeted drugs for treatment.<h4>Methods</h4>We conducted a systematic review on SNPs in genes related to PTSD pathology and development of targeted pharmacological treatment options based on PubMed database searches. We focused on clinical trials with military personnel.<h4>Results</h4>SNPs in 22 human genes have been linked to PTSD. These genes encode proteins acting as neurotransmitters and receptors, downstream signal transducers and metabolizing enzymes. Pharmacological inhibitors may serve as drug candidates for PTSD treatment, e.g. β2 adrenoreceptor antagonists, dopamine antagonists, partial dopamine D2 receptor agonists, dopamine β hydroxylase inhibitors, fatty acid amid hydrolase antagonists, glucocorticoid receptor agonists, tropomyosin receptor kinase B agonists, selective serotonin reuptake inhibitors, catechol-O-methyltransferase inhibitors, gamma-amino butyric acid receptor agonists, glutamate receptor inhibitors, monoaminoxidase B inhibitors, N-methyl-d-aspartate receptor antagonists.<h4>Conclusion</h4>The combination of genetic and pharmacological research may lead to novel targetbased drug developments with improved specificity and efficacy to treat PTSD. Specific SNPs may be identified as reliable biomarkers to assess individual disease risk. Focusing on soldiers suffering from PTSD will not only help to improve treatment options for this specific group, but for all PTSD patients and the general population.
Addresses
  • Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz. Germany.
Autoren
DOI
10.2174/1570159x15666161111113514
eISSN
1875-6190
Externe Identifier
  • PubMed Identifier: 27834145
  • PubMed Central ID: PMC5652029
Open access
true
ISSN
1570-159X
Ausgabe der Veröffentlichung
6
Zeitschrift
Current neuropharmacology
Schlüsselwörter
  • Animals
  • Humans
  • Genetic Predisposition to Disease
  • Stress Disorders, Post-Traumatic
  • Military Personnel
  • Clinical Trials as Topic
  • Gene-Environment Interaction
Sprache
eng
Medium
Print
Open access status
Open Access
Paginierung
831 - 860
Datum der Veröffentlichung
2017
Status
Published
Publisher licence
CC BY-NC
Datum der Datenerfassung
2016
Titel
Pharmacogenetics and Pharmacotherapy of Military Personnel Suffering from Post-traumatic Stress Disorder.
Sub types
  • Systematic Review
  • review-article
  • Review
  • Journal Article
Ausgabe der Zeitschrift
15

Files

https://europepmc.org/articles/PMC5652029?pdf=render

Data source: Europe PubMed Central

Abstract
BACKGROUND: Posttraumatic stress disorder (PTSD) is a severe problem among soldiers with combating experience difficult to treat. The pathogenesis is still not fully understood at the psychological level. Therefore, genetic research became a focus of interest. The identification of single nucleotide polymorphisms (SNPs) may help to predict, which persons are at high risk to develop PTSD as a starting point to develop novel targeted drugs for treatment. METHODS: We conducted a systematic review on SNPs in genes related to PTSD pathology and development of targeted pharmacological treatment options based on PubMed database searches. We focused on clinical trials with military personnel. RESULTS: SNPs in 22 human genes have been linked to PTSD. These genes encode proteins acting as neurotransmitters and receptors, downstream signal transducers and metabolizing enzymes. Pharmacological inhibitors may serve as drug candidates for PTSD treatment, e.g. β2 adrenoreceptor antagonists, dopamine antagonists, partial dopamine D2 receptor agonists, dopamine β hydroxylase inhibitors, fatty acid amid hydrolase antagonists, glucocorticoid receptor agonists, tropomyosin receptor kinase B agonists, selective serotonin reuptake inhibitors, catechol-O-methyltransferase inhibitors, gamma-amino butyric acid receptor agonists, glutamate receptor inhibitors, monoaminoxidase B inhibitors, N-methyl-d-aspartate receptor antagonists. CONCLUSION: The combination of genetic and pharmacological research may lead to novel targetbased drug developments with improved specificity and efficacy to treat PTSD. Specific SNPs may be identified as reliable biomarkers to assess individual disease risk. Focusing on soldiers suffering from PTSD will not only help to improve treatment options for this specific group, but for all PTSD patients and the general population.
Date of acceptance
2016
Autoren
  • Janine Naß
  • Thomas Efferth
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/27834145
DOI
10.2174/1570159X15666161111113514
eISSN
1875-6190
Externe Identifier
  • PubMed Central ID: PMC5652029
Ausgabe der Veröffentlichung
6
Zeitschrift
Curr Neuropharmacol
Schlüsselwörter
  • DNA
  • gene-environment interactions
  • genetics
  • mental diseases
  • pharmacology
  • single nucleotide polymorphisms
  • Animals
  • Clinical Trials as Topic
  • Gene-Environment Interaction
  • Genetic Predisposition to Disease
  • Humans
  • Military Personnel
  • Stress Disorders, Post-Traumatic
Sprache
eng
Country
United Arab Emirates
Paginierung
831 - 860
PII
CN-EPUB-79662
Datum der Veröffentlichung
2017
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2018
Titel
Pharmacogenetics and Pharmacotherapy of Military Personnel Suffering from Post-traumatic Stress Disorder.
Sub types
  • Journal Article
  • Review
  • Systematic Review
Ausgabe der Zeitschrift
15

Data source: PubMed

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