Cancer combination therapies with artemisinin-type drugs
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Thomas Efferth
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000408181400006&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1016/j.bcp.2017.03.019
- eISSN
- 1873-2968
- Externe Identifier
- Clarivate Analytics Document Solution ID: FE4JY
- PubMed Identifier: 28366726
- ISSN
- 0006-2952
- Zeitschrift
- BIOCHEMICAL PHARMACOLOGY
- Schlüsselwörter
- Chemotherapy
- Drug resistance
- Natural products
- Sesquiterpenoids
- Toxicology
- Paginierung
- 56 - 70
- Datum der Veröffentlichung
- 2017
- Status
- Published
- Titel
- Cancer combination therapies with artemisinin-type drugs
- Sub types
- Article
- Proceedings Paper
- Ausgabe der Zeitschrift
- 139
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Thomas Efferth
- DOI
- 10.1016/j.bcp.2017.03.019
- ISSN
- 0006-2952
- Zeitschrift
- Biochemical Pharmacology
- Sprache
- en
- Paginierung
- 56 - 70
- Datum der Veröffentlichung
- 2017
- Status
- Published
- Herausgeber
- Elsevier BV
- Herausgeber URL
- http://dx.doi.org/10.1016/j.bcp.2017.03.019
- Datum der Datenerfassung
- 2023
- Titel
- Cancer combination therapies with artemisinin-type drugs
- Ausgabe der Zeitschrift
- 139
Data source: Crossref
- Abstract
- Artemisia annua L. is a Chinese medicinal plant, which is used throughout Asia and Africa as tea or press juice to treat malaria. The bioactivity of its chemical constituent, artemisinin is, however, much broader. We and others found that artemisinin and its derivatives also exert profound activity against tumor cells in vitro and in vivo. Should artemisinin-type drugs be applied routinely in clinical oncology in the future, then it should probably be as part of combination therapy regimens rather than as monotherapy. In the present review, I give a comprehensive overview on synergistic and additive effects of artemisinin-type drugs in combination with different types of cytotoxic agents and treatment modalities: (a) standard chemotherapeutic drugs, (b) radiotherapy and photodynamic therapy, (c) established drugs for other indications than cancer, (d) novel synthetic compounds, (e) natural products and natural product derivatives, (f) therapeutic antibodies and recombinant proteins, and (g) RNA interference. I also summarize the activity of artemisinin-type drugs towards multidrug-resistant cells and tumor cells with other drug resistance phenomena. As synergistic interactions may not only occur in tumor cells, toxic reactions in normal cells (hepatotoxicity, drug interactions) were also considered. This review summarizes the scientific literature of more than 20years until the end of 2016.
- Addresses
- Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany. Electronic address: efferth@uni-mainz.de.
- Autoren
- Thomas Efferth
- Thomas Efferth
- DOI
- 10.1016/j.bcp.2017.03.019
- eISSN
- 1873-2968
- Externe Identifier
- PubMed Identifier: 28366726
- Open access
- false
- ISSN
- 0006-2952
- Zeitschrift
- Biochemical pharmacology
- Schlüsselwörter
- Cell Line, Tumor
- Animals
- Humans
- Neoplasms
- Sesquiterpenes
- Artemisinins
- Antineoplastic Agents, Phytogenic
- Antineoplastic Combined Chemotherapy Protocols
- Biological Products
- Drugs, Investigational
- Combined Modality Therapy
- Drug Resistance, Multiple
- Drug Interactions
- Drug Synergism
- Drug Resistance, Neoplasm
- Chemical and Drug Induced Liver Injury
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2017
- Paginierung
- 56 - 70
- Datum der Veröffentlichung
- 2017
- Status
- Published
- Datum der Datenerfassung
- 2017
- Titel
- Cancer combination therapies with artemisinin-type drugs.
- Sub types
- Review
- Journal Article
- Ausgabe der Zeitschrift
- 139
Data source: Europe PubMed Central
- Abstract
- Artemisia annua L. is a Chinese medicinal plant, which is used throughout Asia and Africa as tea or press juice to treat malaria. The bioactivity of its chemical constituent, artemisinin is, however, much broader. We and others found that artemisinin and its derivatives also exert profound activity against tumor cells in vitro and in vivo. Should artemisinin-type drugs be applied routinely in clinical oncology in the future, then it should probably be as part of combination therapy regimens rather than as monotherapy. In the present review, I give a comprehensive overview on synergistic and additive effects of artemisinin-type drugs in combination with different types of cytotoxic agents and treatment modalities: (a) standard chemotherapeutic drugs, (b) radiotherapy and photodynamic therapy, (c) established drugs for other indications than cancer, (d) novel synthetic compounds, (e) natural products and natural product derivatives, (f) therapeutic antibodies and recombinant proteins, and (g) RNA interference. I also summarize the activity of artemisinin-type drugs towards multidrug-resistant cells and tumor cells with other drug resistance phenomena. As synergistic interactions may not only occur in tumor cells, toxic reactions in normal cells (hepatotoxicity, drug interactions) were also considered. This review summarizes the scientific literature of more than 20years until the end of 2016.
- Date of acceptance
- 2017
- Autoren
- Thomas Efferth
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/28366726
- DOI
- 10.1016/j.bcp.2017.03.019
- eISSN
- 1873-2968
- Zeitschrift
- Biochem Pharmacol
- Schlüsselwörter
- Chemotherapy
- Drug resistance
- Natural products
- Sesquiterpenoids
- Toxicology
- Animals
- Antineoplastic Agents, Phytogenic
- Antineoplastic Combined Chemotherapy Protocols
- Artemisinins
- Biological Products
- Cell Line, Tumor
- Chemical and Drug Induced Liver Injury
- Combined Modality Therapy
- Drug Interactions
- Drug Resistance, Multiple
- Drug Resistance, Neoplasm
- Drug Synergism
- Drugs, Investigational
- Humans
- Neoplasms
- Sesquiterpenes
- Sprache
- eng
- Country
- England
- Paginierung
- 56 - 70
- PII
- S0006-2952(17)30181-8
- Datum der Veröffentlichung
- 2017
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2017
- Titel
- Cancer combination therapies with artemisinin-type drugs.
- Sub types
- Journal Article
- Review
- Ausgabe der Zeitschrift
- 139
Data source: PubMed
- Beziehungen:
- Property of