Integration of phytochemicals and phytotherapy into cancer precision medicine
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Thomas Efferth
- Mohamed EM Saeed
- Elhaj Mirghani
- Awadh Alim
- Zahir Yassin
- Elfatih Saeed
- Hassan E Khalid
- Salah Daak
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000406232400148&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.18632/oncotarget.17466
- eISSN
- 1949-2553
- Externe Identifier
- Clarivate Analytics Document Solution ID: FB6DV
- PubMed Identifier: 28514737
- Ausgabe der Veröffentlichung
- 30
- Zeitschrift
- ONCOTARGET
- Schlüsselwörter
- drug resistance
- network pharmacology
- polypharmacology
- targeted chemotherapy
- Paginierung
- 50284 - 50304
- Datum der Veröffentlichung
- 2017
- Status
- Published
- Titel
- Integration of phytochemicals and phytotherapy into cancer precision medicine
- Sub types
- Review
- Ausgabe der Zeitschrift
- 8
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Thomas Efferth
- Mohamed EM Saeed
- Elhaj Mirghani
- Awadh Alim
- Zahir Yassin
- Elfatih Saeed
- Hassan E Khalid
- Salah Daak
- DOI
- 10.18632/oncotarget.17466
- eISSN
- 1949-2553
- Ausgabe der Veröffentlichung
- 30
- Zeitschrift
- Oncotarget
- Sprache
- en
- Online publication date
- 2017
- Paginierung
- 50284 - 50304
- Datum der Veröffentlichung
- 2017
- Status
- Published
- Herausgeber
- Impact Journals, LLC
- Herausgeber URL
- http://dx.doi.org/10.18632/oncotarget.17466
- Datum der Datenerfassung
- 2022
- Titel
- Integration of phytochemicals and phytotherapy into cancer precision medicine
- Ausgabe der Zeitschrift
- 8
Data source: Crossref
- Abstract
- Concepts of individualized therapy in the 1970s and 1980s attempted to develop predictive in vitro tests for individual drug responsiveness without reaching clinical routine. Precision medicine attempts to device novel individual cancer therapy strategies. Using bioinformatics, relevant knowledge is extracted from huge data amounts. However, tumor heterogeneity challenges chemotherapy due to genetically and phenotypically different cell subpopulations, which may lead to refractory tumors. Natural products always served as vital resources for cancer therapy (e.g., Vinca alkaloids, camptothecin, paclitaxel, etc.) and are also sources for novel drugs. Targeted drugs developed to specifically address tumor-related proteins represent the basis of precision medicine. Natural products from plants represent excellent resource for targeted therapies. Phytochemicals and herbal mixtures act multi-specifically, i.e. they attack multiple targets at the same time. Network pharmacology facilitates the identification of the complexity of pharmacogenomic networks and new signaling networks that are distorted in tumors. In the present review, we give a conceptual overview, how the problem of drug resistance may be approached by integrating phytochemicals and phytotherapy into academic western medicine. Modern technology platforms (e.g. "-omics" technologies, DNA/RNA sequencing, and network pharmacology) can be applied for diverse treatment modalities such as cytotoxic and targeted chemotherapy as well as phytochemicals and phytotherapy. Thereby, these technologies represent an integrative momentum to merge the best of two worlds: clinical oncology and traditional medicine. In conclusion, the integration of phytochemicals and phytotherapy into cancer precision medicine represents a valuable asset to chemically synthesized chemicals and therapeutic antibodies.
- Addresses
- Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany.
- Autoren
- Thomas Efferth
- Thomas Efferth
- Mohamed EM Saeed
- Elhaj Mirghani
- Awadh Alim
- Zahir Yassin
- Elfatih Saeed
- Hassan E Khalid
- Salah Daak
- DOI
- 10.18632/oncotarget.17466
- eISSN
- 1949-2553
- Externe Identifier
- PubMed Identifier: 28514737
- PubMed Central ID: PMC5564849
- Open access
- true
- ISSN
- 1949-2553
- Ausgabe der Veröffentlichung
- 30
- Zeitschrift
- Oncotarget
- Schlüsselwörter
- Humans
- Phytotherapy
- Phytochemicals
- Precision Medicine
- Sprache
- eng
- Medium
- Open access status
- Open Access
- Paginierung
- 50284 - 50304
- Datum der Veröffentlichung
- 2017
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2017
- Titel
- Integration of phytochemicals and phytotherapy into cancer precision medicine.
- Sub types
- review-article
- Review
- Journal Article
- Ausgabe der Zeitschrift
- 8
Files
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=17466&path%5B%5D=55889 https://europepmc.org/articles/PMC5564849?pdf=render
Data source: Europe PubMed Central
- Abstract
- Concepts of individualized therapy in the 1970s and 1980s attempted to develop predictive in vitro tests for individual drug responsiveness without reaching clinical routine. Precision medicine attempts to device novel individual cancer therapy strategies. Using bioinformatics, relevant knowledge is extracted from huge data amounts. However, tumor heterogeneity challenges chemotherapy due to genetically and phenotypically different cell subpopulations, which may lead to refractory tumors. Natural products always served as vital resources for cancer therapy (e.g., Vinca alkaloids, camptothecin, paclitaxel, etc.) and are also sources for novel drugs. Targeted drugs developed to specifically address tumor-related proteins represent the basis of precision medicine. Natural products from plants represent excellent resource for targeted therapies. Phytochemicals and herbal mixtures act multi-specifically, i.e. they attack multiple targets at the same time. Network pharmacology facilitates the identification of the complexity of pharmacogenomic networks and new signaling networks that are distorted in tumors. In the present review, we give a conceptual overview, how the problem of drug resistance may be approached by integrating phytochemicals and phytotherapy into academic western medicine. Modern technology platforms (e.g. "-omics" technologies, DNA/RNA sequencing, and network pharmacology) can be applied for diverse treatment modalities such as cytotoxic and targeted chemotherapy as well as phytochemicals and phytotherapy. Thereby, these technologies represent an integrative momentum to merge the best of two worlds: clinical oncology and traditional medicine. In conclusion, the integration of phytochemicals and phytotherapy into cancer precision medicine represents a valuable asset to chemically synthesized chemicals and therapeutic antibodies.
- Date of acceptance
- 2017
- Autoren
- Thomas Efferth
- Mohamed EM Saeed
- Elhaj Mirghani
- Awadh Alim
- Zahir Yassin
- Elfatih Saeed
- Hassan E Khalid
- Salah Daak
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/28514737
- DOI
- 10.18632/oncotarget.17466
- eISSN
- 1949-2553
- Externe Identifier
- PubMed Central ID: PMC5564849
- Ausgabe der Veröffentlichung
- 30
- Zeitschrift
- Oncotarget
- Schlüsselwörter
- drug resistance
- network pharmacology
- polypharmacology
- targeted chemotherapy
- Humans
- Phytochemicals
- Phytotherapy
- Precision Medicine
- Sprache
- eng
- Country
- United States
- Paginierung
- 50284 - 50304
- PII
- 17466
- Datum der Veröffentlichung
- 2017
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2018
- Titel
- Integration of phytochemicals and phytotherapy into cancer precision medicine.
- Sub types
- Journal Article
- Review
- Ausgabe der Zeitschrift
- 8
Data source: PubMed
- Beziehungen:
- Property of