Antiproliferative activity against leukemia cells of sesquiterpene lactones from the Turkish endemic plant Centaurea drabifolia subsp detonsa
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Carmen Formisano
- Carmina Sirignano
- Daniela Rigano
- Giuseppina Chianese
- Gokhan Zengin
- Ean-Jeong Seo
- Thomas Efferth
- Orazio Taglialatela-Scafati
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000407404000014&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1016/j.fitote.2017.05.016
- eISSN
- 1873-6971
- Externe Identifier
- Clarivate Analytics Document Solution ID: FD2ZT
- PubMed Identifier: 28579551
- ISSN
- 0367-326X
- Zeitschrift
- FITOTERAPIA
- Schlüsselwörter
- Centaurea drabifolia
- Sesquiterpene lactones
- Cynaropicrin
- Antileukemic activity
- Multidrug-resistant cell lines
- Paginierung
- 98 - 102
- Datum der Veröffentlichung
- 2017
- Status
- Published
- Titel
- Antiproliferative activity against leukemia cells of sesquiterpene lactones from the Turkish endemic plant <i>Centaurea drabifolia</i> subsp <i>detonsa</i>
- Sub types
- Article
- Ausgabe der Zeitschrift
- 120
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Carmen Formisano
- Carmina Sirignano
- Daniela Rigano
- Giuseppina Chianese
- Gokhan Zengin
- Ean-Jeong Seo
- Thomas Efferth
- Orazio Taglialatela-Scafati
- DOI
- 10.1016/j.fitote.2017.05.016
- ISSN
- 0367-326X
- Zeitschrift
- Fitoterapia
- Sprache
- en
- Paginierung
- 98 - 102
- Datum der Veröffentlichung
- 2017
- Status
- Published
- Herausgeber
- Elsevier BV
- Herausgeber URL
- http://dx.doi.org/10.1016/j.fitote.2017.05.016
- Datum der Datenerfassung
- 2018
- Titel
- Antiproliferative activity against leukemia cells of sesquiterpene lactones from the Turkish endemic plant Centaurea drabifolia subsp. detonsa
- Ausgabe der Zeitschrift
- 120
Data source: Crossref
- Abstract
- The apolar organic extract obtained from aerial parts of Centaurea drabifolia Sibth. & Sm. subsp. detonsa (Bornm.) Wagenitz, growing wild in Turkey, was investigated for the first time for its secondary metabolite composition. Seven sesquiterpene lactones belonging to the guaiane class (1-7), including the new compound 4, along with a fatty acid lactone derivative (8), were isolated. The structures of these compounds were established by spectroscopic analysis, including 2D NMR spectroscopic techniques, with the stereostructure of the new guaiane 4 determined with the help of MTPA derivatization. Cytotoxic activities of compounds 1-7 were evaluated against two cancer cell lines, namely acute lymphoblastic leukemia (CCRF-CEM) and its multidrug-resistant subline CEM/ADR5000. Results showed that aguerin B (1) and cynaropicrin (2) showed a potent activity on both cell lines revealing interesting details about the structure-activity relationships in the class of acylated guaiane sesquiterpenes.
- Addresses
- Department of Pharmacy, University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy. Electronic address: caformis@unina.it.
- Autoren
- Carmen Formisano
- Carmina Sirignano
- Daniela Rigano
- Giuseppina Chianese
- Gokhan Zengin
- Ean-Jeong Seo
- Thomas Efferth
- Thomas Efferth
- Orazio Taglialatela-Scafati
- DOI
- 10.1016/j.fitote.2017.05.016
- eISSN
- 1873-6971
- Externe Identifier
- PubMed Identifier: 28579551
- Open access
- false
- ISSN
- 0367-326X
- Zeitschrift
- Fitoterapia
- Schlüsselwörter
- Cell Line, Tumor
- Humans
- Centaurea
- Plant Components, Aerial
- Leukemia
- Sesquiterpenes
- Sesquiterpenes, Guaiane
- Lactones
- Plant Extracts
- Antineoplastic Agents, Phytogenic
- Drug Screening Assays, Antitumor
- Molecular Structure
- Structure-Activity Relationship
- Drug Resistance, Neoplasm
- Turkey
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2017
- Paginierung
- 98 - 102
- Datum der Veröffentlichung
- 2017
- Status
- Published
- Datum der Datenerfassung
- 2017
- Titel
- Antiproliferative activity against leukemia cells of sesquiterpene lactones from the Turkish endemic plant Centaurea drabifolia subsp. detonsa.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 120
Data source: Europe PubMed Central
- Abstract
- The apolar organic extract obtained from aerial parts of Centaurea drabifolia Sibth. & Sm. subsp. detonsa (Bornm.) Wagenitz, growing wild in Turkey, was investigated for the first time for its secondary metabolite composition. Seven sesquiterpene lactones belonging to the guaiane class (1-7), including the new compound 4, along with a fatty acid lactone derivative (8), were isolated. The structures of these compounds were established by spectroscopic analysis, including 2D NMR spectroscopic techniques, with the stereostructure of the new guaiane 4 determined with the help of MTPA derivatization. Cytotoxic activities of compounds 1-7 were evaluated against two cancer cell lines, namely acute lymphoblastic leukemia (CCRF-CEM) and its multidrug-resistant subline CEM/ADR5000. Results showed that aguerin B (1) and cynaropicrin (2) showed a potent activity on both cell lines revealing interesting details about the structure-activity relationships in the class of acylated guaiane sesquiterpenes.
- Date of acceptance
- 2017
- Autoren
- Carmen Formisano
- Carmina Sirignano
- Daniela Rigano
- Giuseppina Chianese
- Gokhan Zengin
- Ean-Jeong Seo
- Thomas Efferth
- Orazio Taglialatela-Scafati
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/28579551
- DOI
- 10.1016/j.fitote.2017.05.016
- eISSN
- 1873-6971
- Zeitschrift
- Fitoterapia
- Schlüsselwörter
- Antileukemic activity
- Centaurea drabifolia
- Cynaropicrin
- Multidrug-resistant cell lines
- Sesquiterpene lactones
- Antineoplastic Agents, Phytogenic
- Cell Line, Tumor
- Centaurea
- Drug Resistance, Neoplasm
- Drug Screening Assays, Antitumor
- Humans
- Lactones
- Leukemia
- Molecular Structure
- Plant Components, Aerial
- Plant Extracts
- Sesquiterpenes
- Sesquiterpenes, Guaiane
- Structure-Activity Relationship
- Turkey
- Sprache
- eng
- Country
- Netherlands
- Paginierung
- 98 - 102
- PII
- S0367-326X(17)30517-8
- Datum der Veröffentlichung
- 2017
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2017
- Titel
- Antiproliferative activity against leukemia cells of sesquiterpene lactones from the Turkish endemic plant Centaurea drabifolia subsp. detonsa.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 120
Data source: PubMed
- Beziehungen:
- Property of