Potential of Central, Eastern and Western Africa Medicinal Plants for Cancer Therapy: Spotlight on Resistant Cells and Molecular Targets
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Armelle T Mbaveng
- Victor Kuete
- Thomas Efferth
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000402508100001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.3389/fphar.2017.00343
- eISSN
- 1663-9812
- Externe Identifier
- Clarivate Analytics Document Solution ID: EW4XS
- PubMed Identifier: 28626426
- Zeitschrift
- FRONTIERS IN PHARMACOLOGY
- Schlüsselwörter
- Africa
- cancer
- plants
- phytochemicals
- molecular targets
- resistance
- Artikelnummer
- ARTN 343
- Datum der Veröffentlichung
- 2017
- Status
- Published
- Titel
- Potential of Central, Eastern and Western Africa Medicinal Plants for Cancer Therapy: Spotlight on Resistant Cells and Molecular Targets
- Sub types
- Review
- Ausgabe der Zeitschrift
- 8
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Armelle T Mbaveng
- Victor Kuete
- Thomas Efferth
- DOI
- 10.3389/fphar.2017.00343
- eISSN
- 1663-9812
- Zeitschrift
- Frontiers in Pharmacology
- Online publication date
- 2017
- Status
- Published online
- Herausgeber
- Frontiers Media SA
- Herausgeber URL
- http://dx.doi.org/10.3389/fphar.2017.00343
- Datum der Datenerfassung
- 2017
- Titel
- Potential of Central, Eastern and Western Africa Medicinal Plants for Cancer Therapy: Spotlight on Resistant Cells and Molecular Targets
- Ausgabe der Zeitschrift
- 8
Data source: Crossref
- Abstract
- Cancer remains a major health hurdle worldwide and has moved from the third leading cause of death in the year 1990 to second place after cardiovascular disease since 2013. Chemotherapy is one of the most widely used treatment modes; however, its efficiency is limited due to the resistance of cancer cells to cytotoxic agents. The present overview deals with the potential of the flora of Central, Eastern and Western African (CEWA) regions as resource for anticancer drug discovery. It also reviews the molecular targets of phytochemicals of these plants such as ABC transporters, namely P-glycoprotein (P-gp), multi drug-resistance-related proteins (MRPs), breast cancer resistance protein (BCRP, ABCG2) as well as the epidermal growth factor receptor (EGFR/ErbB-1/HER1), human tumor suppressor protein p53, caspases, mitochondria, angiogenesis, and components of MAP kinase signaling pathways. Plants with the ability to preferentially kills resistant cancer cells were also reported. Data compiled in the present document were retrieved from scientific websites such as PubMed, Scopus, Sciencedirect, Web-of-Science, and Scholar Google. In summary, plant extracts from CEWA and isolated compounds thereof exert cytotoxic effects by several modes of action including caspases activation, alteration of mitochondrial membrane potential (MMP), induction of reactive oxygen species (ROS) in cancer cells and inhibition of angiogenesis. Ten strongest cytotoxic plants from CEWA recorded following <i>in vitro</i> screening assays are: <i>Beilschmiedia acuta</i> Kosterm, <i>Echinops giganteus</i> var. lelyi (C. D. Adams) A. Rich., <i>Erythrina sigmoidea</i> Hua (Fabaceae), <i>Imperata cylindrical</i> Beauv. var. koenigii Durand et Schinz, <i>Nauclea pobeguinii</i> (Pobég. ex Pellegr.) Merr. ex E.M.A., <i>Piper capense</i> L.f., <i>Polyscias fulva</i> (Hiern) Harms., <i>Uapaca togoensis</i> Pax., <i>Vepris soyauxii</i> Engl. and <i>Xylopia aethiopica</i> (Dunal) A. Rich. Prominent antiproliferative compounds include: isoquinoline alkaloid isotetrandrine (<b>51</b>), two benzophenones: guttiferone E (<b>26</b>) and isoxanthochymol (<b>30</b>), the isoflavonoid 6α-hydroxyphaseollidin (<b>9</b>), the naphthyl butenone guieranone A (<b>25</b>), two naphthoquinones: 2-acetylfuro-1,4-naphthoquinone (<b>4</b>) and plumbagin (<b>37</b>) and xanthone V<sub>1</sub> (<b>46</b>). However, only few research activities in the African continent focus on cytotoxic drug discovery from botanicals. The present review is expected to stimulate further scientific efforts to better valorize the African flora.
- Addresses
- Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of MainzMainz, Germany.
- Autoren
- Armelle T Mbaveng
- Victor Kuete
- Thomas Efferth
- Thomas Efferth
- DOI
- 10.3389/fphar.2017.00343
- eISSN
- 1663-9812
- Externe Identifier
- PubMed Identifier: 28626426
- PubMed Central ID: PMC5454075
- Funding acknowledgements
- Alexander von Humboldt-Stiftung: 2015–2018 Linkage program
- Open access
- true
- ISSN
- 1663-9812
- Zeitschrift
- Frontiers in pharmacology
- Sprache
- eng
- Medium
- Electronic-eCollection
- Online publication date
- 2017
- Open access status
- Open Access
- Paginierung
- 343
- Datum der Veröffentlichung
- 2017
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2017
- Titel
- Potential of Central, Eastern and Western Africa Medicinal Plants for Cancer Therapy: Spotlight on Resistant Cells and Molecular Targets.
- Sub types
- review-article
- Review
- Journal Article
- Ausgabe der Zeitschrift
- 8
Files
https://www.frontiersin.org/articles/10.3389/fphar.2017.00343/pdf https://europepmc.org/articles/PMC5454075?pdf=render
Data source: Europe PubMed Central
- Abstract
- Cancer remains a major health hurdle worldwide and has moved from the third leading cause of death in the year 1990 to second place after cardiovascular disease since 2013. Chemotherapy is one of the most widely used treatment modes; however, its efficiency is limited due to the resistance of cancer cells to cytotoxic agents. The present overview deals with the potential of the flora of Central, Eastern and Western African (CEWA) regions as resource for anticancer drug discovery. It also reviews the molecular targets of phytochemicals of these plants such as ABC transporters, namely P-glycoprotein (P-gp), multi drug-resistance-related proteins (MRPs), breast cancer resistance protein (BCRP, ABCG2) as well as the epidermal growth factor receptor (EGFR/ErbB-1/HER1), human tumor suppressor protein p53, caspases, mitochondria, angiogenesis, and components of MAP kinase signaling pathways. Plants with the ability to preferentially kills resistant cancer cells were also reported. Data compiled in the present document were retrieved from scientific websites such as PubMed, Scopus, Sciencedirect, Web-of-Science, and Scholar Google. In summary, plant extracts from CEWA and isolated compounds thereof exert cytotoxic effects by several modes of action including caspases activation, alteration of mitochondrial membrane potential (MMP), induction of reactive oxygen species (ROS) in cancer cells and inhibition of angiogenesis. Ten strongest cytotoxic plants from CEWA recorded following in vitro screening assays are: Beilschmiedia acuta Kosterm, Echinops giganteus var. lelyi (C. D. Adams) A. Rich., Erythrina sigmoidea Hua (Fabaceae), Imperata cylindrical Beauv. var. koenigii Durand et Schinz, Nauclea pobeguinii (Pobég. ex Pellegr.) Merr. ex E.M.A., Piper capense L.f., Polyscias fulva (Hiern) Harms., Uapaca togoensis Pax., Vepris soyauxii Engl. and Xylopia aethiopica (Dunal) A. Rich. Prominent antiproliferative compounds include: isoquinoline alkaloid isotetrandrine (51), two benzophenones: guttiferone E (26) and isoxanthochymol (30), the isoflavonoid 6α-hydroxyphaseollidin (9), the naphthyl butenone guieranone A (25), two naphthoquinones: 2-acetylfuro-1,4-naphthoquinone (4) and plumbagin (37) and xanthone V1 (46). However, only few research activities in the African continent focus on cytotoxic drug discovery from botanicals. The present review is expected to stimulate further scientific efforts to better valorize the African flora.
- Date of acceptance
- 2017
- Autoren
- Armelle T Mbaveng
- Victor Kuete
- Thomas Efferth
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/28626426
- DOI
- 10.3389/fphar.2017.00343
- Externe Identifier
- PubMed Central ID: PMC5454075
- ISSN
- 1663-9812
- Zeitschrift
- Front Pharmacol
- Schlüsselwörter
- Africa
- cancer
- molecular targets
- phytochemicals
- plants
- resistance
- Sprache
- eng
- Country
- Switzerland
- Paginierung
- 343
- Datum der Veröffentlichung
- 2017
- Status
- Published online
- Titel
- Potential of Central, Eastern and Western Africa Medicinal Plants for Cancer Therapy: Spotlight on Resistant Cells and Molecular Targets.
- Sub types
- Journal Article
- Review
- Ausgabe der Zeitschrift
- 8
Data source: PubMed
- Beziehungen:
- Property of